Research theme for competitive and other funds (19)：
2023 - 2027 Exploration of anti-aging and/or skin-lightening cosmetic agents from mushrooms
2024 - 2026 Biological and chemical profiling and database registration of mushrooms with unknown palatability for the prevention of mushroom poisoning
2022 - 2023 Exploration of new agrochemical leads from rhizobacteria and mushrooms
2018 - 2021 Investigation on the distribution of alkylglycerolipids in Chlorophyta
2020 - 2021 Chemical investigation of mushrooms in Toyama for food intoxication observation and development of new agrochemicals
2019 - 2020 Structure and bioactivity of metabolites from plant growth-promoting rhizobacteria
2016 - 2019 The impact of beta-glucosidase on cellulase production by filamentous fungi
2014 - 2018 Chemical studies on the antifeedants in the skin secretion of the ranid frog Grandilana rugosa against predatory snakes
2017 - 2018 Identification of glycotransfer product
2015 - 2016 Analysis of ether sulfolipids in Aegagropilopsis moravica indigenous to a spring water in Toyama
2014 - 2015 Exploration and Development of potential drug leads from edible cyanobacteria grown in Toyama, "a kingdom of water"
2013 - 2014 Identification of a snake repelling component in the skin excrete of Glandirana rugosa
2012 - 2013 Studies on the structures of two drug leads, nostofungicidine and rakicidin A
2011 - 2012 富山県オリジナルバイオマス「アシツキ」からの医薬探索
2011 - 2012 Bioprospecting in untapped microbes for new drug discovery resources
2010 - 2011 Exploration of
2010 - 2011 Studies on bioactive metabolites from aquatic microbes
2000 - 2002 海洋無脊椎動物からの細胞機能系に作用する物質の探索と作用機序の解明
2000 - 2001 海洋無脊椎動物からの細胞機能系に作用する物質の探索と作用機序の解明
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Papers (70)：
Marwa Elsbaey, Yuki Samaru, Engy Elekhnawy, Naoya Oku, Yasuhiro Igarashi. A new polycyclic tetramate macrolactam from Allostreptomyces RD068384: stereochemistry and antifungal potential. The Journal of antibiotics. 2024. 77. 6. 393-396
Md Julkar Nime, Yuna Oguri, Naoya Oku, Yasuhiro Igarashi. Structure revision of tricholomenyn B, an antimitotic geranylcyclohexenone rediscovered as a bitter and antibacterial substance, from a basidiomycete Tricholoma japonicum (Shiro-shimeji). The Journal of antibiotics. 2024
Kentaro Takada, Naoya Oku, Megan L Peach, Tanya T Ransom, Curtis J Henrich, Kirk R Gustafson. Enigmazole Phosphomacrolides from the Marine Sponge Cinachyrella enigmatica. The Journal of Organic Chemistry. 2023. 88. 15. 10996-11002
Chang Liu, Zhiwei Zhang, Keisuke Fukaya, Naoya Oku, Enjuro Harunari, Daisuke Urabe, Yasuhiro Igarashi. Isolation and structure determination of allopteridic acids A-C and allokutzmicin from an unexplored actinomycete of the genus Allokutzneria. The Journal of Antibiotics. 2023. 76. 6. 305-315
Shiyang Lu, Zhiwei Zhang, Amit Raj Sharma, Junko Nakajima-Shimada, Enjuro Harunari, Naoya Oku, Agus Trianto, Yasuhiro Igarashi. Bulbiferamide, an Antitrypanosomal Hexapeptide Cyclized via an N-Acylindole Linkage from a Marine Obligate Microbulbifer. Journal of Natural Products. 2023. 86. 4. 1081-1086
林昌平, 林昌平, 尾崎太郎, 尾崎太郎, 浅水俊平, 尾仲宏康, 大村智, 供田洋, 池田治生, 奥直也, et al. Genome mining reveals a minimum gene set for the biosynthesis of 32-membered macrocyclic thiopeptides lactazoles. Institute for Fermentation, Osaka. Research Communications. 2018. 32
Naoya OKU. Impressions on the 30th Annual Meeting of the Society for Actinomycetes Japan. Actinomycetologica. 2015. 29. 2. 35-36
Naoya Oku, Kohsuke Yonejima, Atsumi Hasada, Noriaki Matsuoka, Yasuhiro Igarashi, Takao Sugawa, Shouichi Hioroaki, Misawo Hiroaki, Hideharu Honoki, Tatsuru Mano, et al. Exploration of bioactive compounds from indigenous species in Toyama (poster session). Annual Meeting of the Society for the Directors of Toyama Prefectural Institute. 2015
Umeyama Akemi, Oku Naoya, Kawabata Katsutaka, Shizuri Yoshikazu, Ishiyama Aki, Otoguro Kazuhiko, Omura Satoshi, Okada Minori, Nakamura Yukari, Suenaga Midori, et al. P-39 New Cyclic Peptides from the Cordyceps, Ophiocordyceps heteropoda and the Marine Bacterium Photobacterium sp.(Poster Presentation). Symposium on the Chemistry of Natural Products, symposium papers. 2011. 53. 0. 385-390
Oku Naoya, Adachi Kyoko, Matsuda Satoru, Kasai Hiroaki, Takatsuki Akira, Shizuri Yoshikazu. P-55 Ariakemicins A and B, Novel Antibacterial Polyketide-peptides from a Marine Gliding Bacterium of the Genus Rapidithrix(Poster Presentation). Symposium on the Chemistry of Natural Products, symposium papers. 2008. 50. 427-432
Monoacylglycerol, antibacterial, and manufacturing thereof
骨吸収抑制剤
新規エンジイン化合物
Lectures and oral presentations (22)：
Exploration of new agrochemical leads from rhizobacteria or mushrooms
(Pharmaceutical Engineering and Biotechnology Research Center Annual Report Meeting 2023)
Exploration of new agrochemical leads from rhizobacteria or mushrooms
(Association of Supporters for Researchs at Toyama Prefectural University Annual Meeting 2023 2023)
Webinar 8: Basics of Nucleic Acid Therapeutics
(Web Summer School 2022 at Toyama Prefectural University 2022)
Basics of Nucleic Acid Therapeutics
(Web Summer School 2021 at Toyama Prefectural University 2021)
New Antmicrobial Ether Lipids from "Tateyama-marimo" (Aegagropilopsis moravica), a rare species of marimo (Chlorophyta)
(Marine Biotechnology Conference 2019 2019)
1997 - 2002 University of Tokyo Graduate School of Life and Agricultural Sciences Department of Aquatic Bioscience (Prof. Nobuhiro Fusetani)
1995 - 1997 University of Tokyo Faculty of Agriculture Department of Fisheries
1993 - 1995 University of Tokyo Natural Sciences II
Professional career (1)：
Ph.D. (University of Tokyo)
Work history (8)：
2022/04 - 現在 Toyama Prefectural University Laboratory of Microbial Engineering, Department of Biotechnology, Faculty of Engineering, Associate Professor (Prof. Yasuhiro Igarashi)
2015/04 - 2022/03 Toyama Prefectural University Laboratory of Microbial Engineering, Faculty of Engineering, Department of Biotechnology Lecturer (Prof. Yasuhiro Igarashi)
2009/10 - 2015/03 Toyama Prefectural University Laboratory of Microbial Engineering, Faculty of Engineering, Department of Biotechnology Assistant Professor (Prof. Yasuhiro Igarashi)
2007/04 - 2008/02 Sapporo Breweries Frontier Laboratories of Value Creation Contract Researcher
2005/05 - 2007/03 Marine Biotechnology Institute, Co. Applied Bioorganic Chemistry Group (Prof. Yoshikazu Shizuri) Researcher (Prof. Yoshikazu Shizuri)
2002/05 - 2005/05 National Cancer Institute at Frederick, NIH Molecular Targets Discovery Program Visiting Fellow (Dr. Kirk R. Gustafson)
2002/04 - 2002/05 University of Tokyo Graduate School of Life and Agricultural Sciences Postdoctoral Researcher (Prof. Nobuhiro Fusetani)
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Association Membership(s) (4)：
JAPANESE SOCIETY FOR MARINE BIOTECHNOLOGY
, JAPANESE SOCIETY FOR CHEMICAL BIOLOGY
, SOCIETY OF ACTINOMYCETES JAPAN
, JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY
