Rchr
J-GLOBAL ID:201501057964770260
Update date: Nov. 17, 2024
Kimura Yasuyuki
キムラ ヤスユキ | Kimura Yasuyuki
Affiliation and department:
Other affiliations (3):
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National Institutes for Quantum and Radiological Science and Technology
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Fujita Health University
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Gifu University
Homepage URL (1):
https://kaken.nii.ac.jp/d/r/20423171.ja.html
Research field (1):
Radiology
Research keywords (6):
PET
, positron emission tomography
, Alzheimer's disease
, neuroinflammation
, microglia
, ポジトロンエミッショントモグラフィー
Research theme for competitive and other funds (20):
- 2024 - 2027 Evaluation of a PET imaging ligand for microglia in Alzheimer's diseases
- 2023 - 2026 Synthesis of functional PET probes targeting enzymes specifically expressed in glioma
- 2023 - 2025 Development of an in vivo cell tracking method using biological orthogonal reactions and PET
- 2022 - 2025 アルツハイマー病前臨床期の血液およびPETバイオマーカーの有用性に関する調査研究
- 2022 - 2025 The research of the systemic inflammation as a cause of neuropsychiatric symptoms in Alzheimer's disease
- 2021 - 2024 Development of PET imaging of brain immunity as a biomarker for drug development to treat neurodegenerative diseases
- 2021 - 2023 Development of brain PET imaging using bioorthogonal reactions
- 2020 - 2023 特異的発現酵素を標的とした脳腫瘍イメージングPETプローブの斬新化
- 2019 - 2022 In vivo investigation of neuroinflammation of AD with PET molecular imaging
- 2018 - 2021 PET imaging of microglia, a novel drug target for neurodegenerative diseases
- 2018 - 2021 Synthesis of 11C-labeled acyclic retinoids with high brain permeability
- 2019 - 2021 ミクログリア機能を反映するPETイメージングの開発
- 2017 - 2020 PET microdose study for finding appropriate dose of isoproterenol as a disease modifying treatment of dementia
- 2016 - 2020 うつ病の病態に基づく層別化と神経回路調整による革新的診断・治療法開発
- 2017 - 2019 認知症の新規診断・治療薬の薬物動態評価のためのPET first-in-human試験
- 2017 - 2019 (放射性標識)新規AMPA受容体PETイメージング製剤によるてんかん焦点同定の補助診断薬としての臨床開発
- 2015 - 2018 Quantitative PET imaging of AMPA receptors in humans
- 2014 - 2018 Tau PET study for revealing the pathogenesis and establishing the objective marker of disease severity in neurodegenerative dementia
- 2015 - 2017 AMPA型グルタミン酸受容体のヒトにおけるPET定量イメージングの確立
- 2012 - 2015 PET measurements of interaction between glutamatergic and dopaminergic neurons
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Papers (202):
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Keita Sakurai, Daita Kaneda, Satoru Morimoto, Yuto Uchida, Shohei Inui, Cong Shang, Yasuyuki Kimura, Chang Cai, Takashi Kato, Kengo Ito, et al. Medial temporal atrophy predicts the limbic comorbidities in lewy body disease. Neuroradiology. 2024
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Hironobu Endo, Maiko Ono, Yuhei Takado, Kiwamu Matsuoka, Manami Takahashi, Kenji Tagai, Yuko Kataoka, Kosei Hirata, Keisuke Takahata, Chie Seki, et al. Imaging α-synuclein pathologies in animal models and patients with Parkinson's and related diseases. Neuron. 2024. 112. 15. 2540-2557
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安野 史彦, 渡邉 淳, 木村 泰之, 山内 夢叶, 小縣 綾, 阿部 潤一郎, 南 博之, 二橋 尚志, 下田 信義, 春日 健作, et al. アルツハイマー型認知症における血漿IL-6濃度と精神行動症状の関係について. 老年精神医学雑誌. 2024. 35. 増刊II. 236-236
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Fumihiko Yasuno, Yasuyuki Kimura, Aya Ogata, Hiroshi Ikenuma, Junichiro Abe, Hiroyuki Minami, Takashi Nihashi, Kastunori Yokoi, Saori Hattori, Nobuyoshi Shimoda, et al. Trait-anxiety and glial-related neuroinflammation of the amygdala and its associated regions in Alzheimer's disease: A significant correlation. Brain, behavior, & immunity - health. 2024. 38. 100795-100795
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Takashi Nihashi, Keita Sakurai, Takashi Kato, Yasuyuki Kimura, Kengo Ito, Akinori Nakamura, Teruhiko Terasawa. Blood levels of glial fibrillary acidic protein for predicting clinical progression to Alzheimer's disease in adults without dementia: a systematic review and meta-analysis protocol. Diagnostic and prognostic research. 2024. 8. 1. 4-4
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MISC (172):
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古山浩子, 古山浩子, 鈴木恵一, 渡邉涼夏, 木村泰之, 小縣綾, 小縣綾, 池沼宏, 椎名貴彦, 高須蒼生, et al. 中枢神経活性11C標識非環式レチノイドの創製と脳内送達分子機構の解明. 核医学(Web). 2023. 60. Supplement
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木村泰之, 木村泰之, 山田真希子, 島崎聡立, 西野いずみ, 張明栄, 樋口真人, 須原哲也. ヒスタミンH3レセプターのPETイメージング. 応用薬理. 2022. 102. 5-6
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Hiroshi Ikenuma, Aya Ogata, Hiroko Koyama, Takashi Yamada, Junichiro Abe, Masanori Ichise, Takashi Kato, Masaaki Suzuki, Kengo Ito, Yasuyuki Kimura. Development of novel PET ligands to image the receptor interacting protein kinase 1. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2021. 41. 1_SUPPL. 39-40
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Aya Ogata, Takashi Yamada, Junichiro Abe, Masanori Ichise, Hiroshi Ikenuma, Hiroko Koyama, Masaaki Suzuki, Takashi Kato, Kengo Ito, Yasuyuki Kimura. PET imaging of [C-11]NCGG401 for colony stimulating factor 1 receptor. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2021. 41. 1_SUPPL. 42-42
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Takayuki Sakai, Takashi Yamada, Hiroshi Ikenuma, Aya Ogata, Masanori Ichise, Saori Hattori, Junichiro Abe, Masaaki Suzuki, Kengo Ito, Takashi Kato, et al. Development of a novel PET ligand for receptor-interacting protein kinase 1 in brain. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2021. 41. 1_SUPPL. 119-119
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Patents (1):
Lectures and oral presentations (106):
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PETを用いた大脳皮質基底核症候群の背景病理推定に関する検討
(パーキンソン病・運動障害疾患コングレスプログラム・抄録集 2019)
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18F-PM-PBB3 PETは発症前駆期より4リピートタウオパチーの脳病理を捕捉し得る
(パーキンソン病・運動障害疾患コングレスプログラム・抄録集 2019)
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Relationship between the accumulation of THK-5351 and PiB in each cerebral region from cognitively normal to Alzheimer type dementia, a PET study
(JOURNAL OF NUCLEAR MEDICINE 2019)
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18F-PM-PBB3 PETによる4リピートタウオパチーのタウイメージング
(千葉医学雑誌 2019)
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AD continuumにおけるTHK-5351集積と脳萎縮との領域間相関の検討
(核医学 2018)
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Education (2):
- 2002 - 2006 Osaka University Graduate School of Medicine
- 1992 - 1998 Osaka University
Professional career (2):
- MD (Osaka University)
- PhD (Osaka University Graduate School of Medicine)
Work history (6):
- 2021/04 - 現在 国立研究開発法人 国立長寿医療研究センター 認知症先進医療開発センター 脳機能画像診断開発部 副部長
- 2016/10 - 2021/03 National Center for Geriatrics and Gerontology Department of Clinical and Experimental Neuroimaging, Center for Development of Advanced Medicine for Dementia Chief, Section of Imaging Molecules
- 2014/07 - 2016/09 National Institute of Radiological Sciences Molecular Imaging Center Senior researcher
- 2010/10 - 2014/06 National Institutes for Quantum and Radiological Science and Technology
- 2007/12 - 2010/09 National Institute of Mental Health Molecular Imaging Branch Visiting Fellow
- 2006/05 - 2006/07 Imperial College, Hammersmith Hospital MRC Clinical Sciences Centre and Division of Neuroscience Visitor
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Committee career (3):
- 2022/10 - 現在 量子科学技術研究開発機構 臨床研究審査委員会委員
- 2022/06 - 現在 量子科学技術研究開発機構 PET薬剤審査委員会委員
- 2021/05 - 現在 量子科学技術研究開発機構 認定倫理審査委員会 技術専門員
Awards (4):
- 2020/08 - The 14th International Conference on Complex Medical and Engineering (CME2020) Best Conference Paper Award PET Imaging in Drug Development for Neurodegenerative Diseases
- 2014 - Travel awarded winner of the Asian Youth Forum of Nuclear Medicine and Molecular Imaging
- 2011 - 第50回千葉核医学賞
- 2005 - 大阪難病研究財団 海外派遣助成
Association Membership(s) (2):
THE JAPANESE SOCIETY OF INTERNAL MEDICINE
, JAPANESE SOCIETY OF NUCLEAR MEDICINE
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