Ohba Kenji

オオバケンジ | Ohba Kenji

Affiliation and department：
Homepage URL (1)： https://www.jichi.ac.jp/genetherapy/

Research field (10)： Tumor diagnostics and therapeutics , Medical biochemistry , Genomics , Cell biology , Molecular biology , Immunology , Pathobiochemistry , Physiology , Tumor biology , Virology

Research keywords (6)： Genetic Therapy , Immunology , Oncology , Molecular biology , Cell competition , Virology

Research theme for competitive and other funds (7)：

2023 - 2028 次世代医療を目指した再生・細胞医療・遺伝子治療研究開発拠点 (中核拠点)
2023 - 2026 分子特異的DNAアプタマー修飾で細胞特異性を改良した次世代型分子特異的アデノ随伴ウイルス(Apt-AAV)ベクター基盤の研究開発
2020 - 2024 Collaboration for production of AAV vectors
2021 - 2024 Immune cell-like functions of epithelial cells induced by MHC-I signal
2020 - 2023 Analyses of particle formation and infection mechanism for adeno-associated virus

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Papers (35)：

Yoshihide Sehara, Yuki Hashimotodani, Ryota Watano, Kenji Ohba, Ryosuke Uchibori, Kuniko Shimazaki, Kensuke Kawai, Hiroaki Mizukami. Adeno-associated Virus-mediated Ezh2 Knockdown Reduced the Increment of Newborn Neurons Induced by Forebrain Ischemia in Gerbil Dentate Gyrus. Molecular Neurobiology. 2024
Yuka Hayashi, Yoshihide Sehara, Ryota Watano, Kenji Ohba, Yuki Takayanagi, Yoshio Sakiyama, Kazuhiro Muramatsu, Hiroaki Mizukami. Therapeutic Strategy for Fabry Disease by Intravenous Administration of Adeno-Associated Virus 9 in a Symptomatic Mouse Model. Human Gene Therapy. 2024. 35. 5-6. 192-201
Kenji Ohba, Hiroaki Mizukami. Protocol for producing an adeno-associated virus vector by controlling capsid expression timing. STAR Protocols. 2023. 4. 4. 102542-102542
Yuka Hayashi, Yoshihide Sehara, Ryota Watano, Kenji Ohba, Yuki Takayanagi, Kazuhiro Muramatsu, Yoshio Sakiyama, Hiroaki Mizukami. Therapeutic strategy for Fabry disease by intravenous administration of adeno-associated virus 2 or 9 in α-galactosidase A-deficient mice. The Journal of Gene Medicine. 2023. e3560
Kenji Ohba, Yoshihide Sehara, Tatsuji Enoki, Junichi Mineno, Keiya Ozawa, Hiroaki Mizukami. Adeno-associated virus vector system controlling capsid expression improves viral quantity and quality. iScience. 2023. 26. 4. 106487-106487

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MISC (29)：

鈴木陽一, 鈴木陽一, HAN Qi’En, CHIN Wei Xin, LEE Ching Hua, WEN Eyo Zhi, 蝦名博貴, 市山浩二, TAN Beng Hui, 日紫喜隆行, et al. インターフェロン誘導性新規抗デングウイルス因子(RyDEN)の同定とその抑制機構の解明. 日本ウイルス学会学術集会プログラム・抄録集. 2014. 62nd
NOMURA Wataru, HASHIMOTO Chie, NAKAHARA Toru, OHYA Aki, MIYAUCHI Kosuke, OHBA Kenji, NARUMI Tetsuo, AIKAWA Haruo, KOMANO Jun, YAMAMOTO Naoki, et al. Designed Antigens Based on the Dynamic Structural Changes of gp41 for Development of Effective HIV -1 Vaccines. 2012. 2011. 295-296
野村渉, 近藤麻美, 卜部亜里沙, 大庭賢二, 増田朱美, 山本直樹, 梁明秀, 玉村啓和. ウイルスゲノムを標的としたジンクフィンガーヌクレアーゼの構築戦略. 日本薬学会年会要旨集. 2012. 132nd. 3
増田朱美, 野村渉, 大庭賢二, 卜部亜里沙, 山本直樹, 玉村啓和. ジンクフィンガー融合DNA組換え酵素の反応効率最適化. 日本化学会バイオテクノロジー部会シンポジウム講演要旨集. 2011. 14th
橋本知恵, 橋本知恵, 野村渉, 田中智博, 中原徹, 中原徹, 鳴海哲夫, 大庭賢二, 村上努, 山本直樹, et al. エイズワクチンを指向した宿主受容体CXCR4由来抗原分子の創製. 日本薬学会年会要旨集. 2010. 130th. 2

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Patents (2)：

Efficient AAV vector production system
A Method For Diagnosis Of Hpv-related Non-genital Cancers Using PCR

Books (2)：

The development of efficient adeno-associated virus vector production system for gene therapy
Japan Bioindustry Association 2023
HIV感染症における治療と研究
最新医学 2005

Lectures and oral presentations (45)：

遺伝子治療の発展を目指した次世代AAVベクターシステムの開発
(タカラバイオ株式会社社内招待講演 2023)
Efficient adeno-associated virus vector production system through controlling capsid expression timing
(2023)
キャプシドの発現タイミングを調整した効率良いアデノ随伴ウイルスベクター産生システム
(第21回自治医科大学シンポジウム 2023)
Novel adeno-associated virus (AAV) vector production system for gene therapy
(The 69th Annual Meeting of the Japanese Society for Virology 2022)
変異細胞または正常/変異細胞の境界を認識する膜表面分子の探索
(第5回新学術領域班会議ー細胞競合ー 2018)

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Education (3)：

2004 - 2008 Tokyo Medical and Dental University Graduate School of Medical and Dental Science Doctral Program for Medical and Dental Science (Medical Doctor Course)
2002 - 2004 Yokohama-city University Graduate School of Medicine Master Course for Medical Science
1998 - 2002 Rikkyo University College of Science Department of Life Science

Professional career (1)：

Ph.D. (Tokyo Medical and Dental University)

Work history (5)：

2015/03 - 2018/10 Hokkaido University Division of Molecular Oncology, Institute for Genetic Medicine Project Assistant Professor
2010/04 - 2015/03 National University of Singapore Yong Loo Lin School of Medicine, Department of Microbiology Research Fellow
2008/04 - 2010/03 National Institute of Infectious Diseases AIDS Research Center Postdoctoral Fellow
2004/04 - 2008/03 Tokyo Medical and Dental University School of Medicine Ph.D.
2002/04 - 2004/03 Yokohama City University School of Medicine Master

Awards (2)：

2023 - 自治医科大学第21回自治医科大学シンポジウム優秀賞
2023 - 公益財団法人武田科学振興財団医学系研究助成

Association Membership(s) (6)：

European Society of Gene & Cell Therapy , Japan Society of Gene and Cell Therapy , American Society of Gene & Cell Therapy , International Society on Aptamers , 日本ウイルス学会 , The Molecuar Biology Society of Japan

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