Matsuoka Shigeru

マツオカシゲル | Matsuoka Shigeru

Affiliation and department：
Job title： Specially Appointed Professor
Homepage URL (2)： https://kaken.nii.ac.jp/d/r/60456184.ja.html , https://nrid.nii.ac.jp/en/nrid/1000060456184/

Research field (3)： Molecular biochemistry , Pharmaceuticals - chemistry and drug development , Chemical biology

Research keywords (5)： Lipid Bilayer , Molecular Recognition , Small Molecule Drug Discovery , Peptide Mimetics , Protein-Protein Interaction

Research theme for competitive and other funds (6)：

2020 - 2023 molecular design and action mechanism of peptidomimetics using natural products-like cubic scaffolds
2017 - 2020 Ligand recognition mechanism by the secreted scavenger receptor AIM
2013 - 2017 Exploration of natural products and small molecues for mode-of-action study on biomembrane lipids
2014 - 2016 Molecular recognition in the interfacial environment induced by lipid membranes
2012 - 2015 Structural basis for fuzzy molecular recognition by fatty acid-binding protein

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Papers (86)：

Yuichi Umegawa, Sho Kato, Sangjae Seo, Wataru Shinoda, Satoshi Kawatake, Shigeru Matsuoka, Michio Murata. Protein-lipid acyl chain interactions: Depth-dependent changes of segmental mobility of phospholipid in contact with bacteriorhodopsin. Biophysical chemistry. 2024. 308. 107204-107204
Yuichi Umegawa, Satoshi Kawatake, Michio Murata, Shigeru Matsuoka. Combined effect of the head groups and alkyl chains of archaea lipids when interacting with bacteriorhodopsin. Biophysical chemistry. 2023. 294. 106959-106959
Masahiro Nishida, Takeshi Terabayashi, Shigeru Matsuoka, Tomoko Okuma, Sawako Adachi, Tadashi Tomo, Masanori Kawano, Kazuhiro Tanaka, Hiroshi Tsumura, Hirofumi Anai, et al. Mechanism of action of non-camptothecin inhibitor Genz-644282 in topoisomerase I inhibition. Communications Biology. 2022. 5. 1
Shigeru Sugiyama, Daisuke Matsuoka, Toshiaki Hara, Masashi Sonoyama, Shigeru Matsuoka, Michio Murata. Experimental and theoretical investigations into the mechanism of interactions between membrane-bound fatty acids and their binding protein: A model system to investigate the behavior of lipid acyl chains in contact with proteins. Chemistry and Physics of Lipids. 2022. 105227-105227
Yuichi Umegawa, Tomoya Yamamoto, Mayank Dixit, Kosuke Funahashi, Sangjae Seo, Yasuo Nakagawa, Taiga Suzuki, Shigeru Matsuoka, Hiroshi Tsuchikawa, Shinya Hanashima, et al. Amphotericin B assembles into seven-molecule ion channels: An NMR and molecular dynamics study. Science advances. 2022. 8. 24. eabo2658

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MISC (28)：

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Education (4)：

1999 - 2003 Osaka University Graduate School of Science Department of Chemistry
1997 - 1999 The University of Tokyo Graduate School of Science Department of Chemistry
1995 - 1997 The University of Tokyo Faculty of Science Department of Chemistry
1993 - 1995 The University of Tokyo College of Arts and Sciences Science II

Professional career (1)：

Ph.D. (Osaka University)

Work history (8)：

2021/07 - 現在 Oita University Faculty of Medicine Specially Appointed Professor
2021/04 - 現在 Albius Sciences Ltd. Co-founder & Chief Technology Officer
2018/04 - 2021/06 Oita University Faculty of Medicine Specially Appointed Associate Professor
2017/04 - 2018/03 The University of Tokyo Graduate School of Medicine Project Associate Professor
2016/04 - 2017/03 The University of Tokyo Graduate School of Medicine Researcher

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Awards (2)：

2011/03 - 日本薬学会奨励賞
2004/07 - 天然物化学談話会奨励賞

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