Rchr
J-GLOBAL ID：201501084489673988
Update date: Nov. 16, 2024
Matsuoka Shigeru
マツオカ シゲル | Matsuoka Shigeru
Affiliation and department：
Job title：
Specially Appointed Professor
Homepage URL (2)：
https://kaken.nii.ac.jp/d/r/60456184.ja.html
,
https://nrid.nii.ac.jp/en/nrid/1000060456184/
Research field (3)：
Molecular biochemistry
, Pharmaceuticals - chemistry and drug development
, Chemical biology
Research keywords (5)：
Lipid Bilayer
, Molecular Recognition
, Small Molecule Drug Discovery
, Peptide Mimetics
, Protein-Protein Interaction
Research theme for competitive and other funds (9)：
- 2023 - 2026 Development of small molecule mimicking technologies for local structures of biopolymers to contribute to the creation of new medicines
- 2020 - 2023 Development and validation of novel methods for designing small molecule peptidomimetics
- 2020 - 2023 molecular design and action mechanism of peptidomimetics using natural products-like cubic scaffolds
- 2017 - 2020 Ligand recognition mechanism by the secreted scavenger receptor AIM
- 2013 - 2017 Exploration of natural products and small molecues for mode-of-action study on biomembrane lipids
- 2014 - 2016 Molecular recognition in the interfacial environment induced by lipid membranes
- 2012 - 2015 Structural basis for fuzzy molecular recognition by fatty acid-binding protein
- 2008 - 2009 Structural study of the polyglutamine aggregates
- 1999 - 2001 脂質二重膜中におけるポリエン型抗生物質の超分子構造のNMRによる解析
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Papers (88)：
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Takeshi Terabayashi, Daisuke Takezaki, Katsuhiro Hanada, Shigeru Matsuoka, Takako Sasaki, Takahiro Akamine, Akira Katoh, Toshimasa Ishizaki. Timosaponin AIII Disrupts Cell-Extracellular Matrix Interactions through the Inhibition of Endocytic Pathways. Biological and Pharmaceutical Bulletin. 2024. 47. 10. 1648-1656
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Yuichi Umegawa, Sho Kato, Sangjae Seo, Wataru Shinoda, Satoshi Kawatake, Shigeru Matsuoka, Michio Murata. Protein-lipid acyl chain interactions: Depth-dependent changes of segmental mobility of phospholipid in contact with bacteriorhodopsin. Biophysical chemistry. 2024. 308. 107204-107204
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Yuichi Umegawa, Satoshi Kawatake, Michio Murata, Shigeru Matsuoka. Combined effect of the head groups and alkyl chains of archaea lipids when interacting with bacteriorhodopsin. Biophysical chemistry. 2023. 294. 106959-106959
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Masahiro Nishida, Takeshi Terabayashi, Shigeru Matsuoka, Tomoko Okuma, Sawako Adachi, Tadashi Tomo, Masanori Kawano, Kazuhiro Tanaka, Hiroshi Tsumura, Hirofumi Anai, et al. Mechanism of action of non-camptothecin inhibitor Genz-644282 in topoisomerase I inhibition. Communications Biology. 2022. 5. 1
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Shigeru Sugiyama, Daisuke Matsuoka, Toshiaki Hara, Masashi Sonoyama, Shigeru Matsuoka, Michio Murata. Experimental and theoretical investigations into the mechanism of interactions between membrane-bound fatty acids and their binding protein: A model system to investigate the behavior of lipid acyl chains in contact with proteins. Chemistry and Physics of Lipids. 2022. 105227-105227
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MISC (28)：
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中根崇智, 花島慎弥, 鈴木守, 鈴木守, 斎木悠, 林太一, 垣之内啓介, 垣之内啓介, 杉山成, 杉山成, et al. 膜蛋白質のSFXによる迅速位相決定を志向したヨウ素含有界面活性剤の開発. 日本結晶学会年会講演要旨集. 2016. 2016
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上田 慧, 中井 万智, 志波 智生, 高橋 元, 稲岡 ダニエル健, 城戸 康年, 坂元 君年, 柘植 千明, Balogun Emmanuel Oluwadare, 奈良 武司, et al. アフリカトリパノソーマのシアン耐性酸化酵素(TAO)と異なる骨格をもつ阻害剤、アスコフラノン及びフェルレノールとの複合体構造. 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集. 2015. 88回・38回. [1P0388]-[1P0388]
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Balogun Emmanuel O, 稲岡 ダニエル健, 志波 智生, 城戸 康年, 奈良 武司, 青木 孝, 本間 光貴, 田仲 昭子, 井上 将行, 松岡 茂, et al. アフリカトリパノソーマに対する理論的な薬剤の開発のためのグリセロールキナーゼの標的化(Targeting glycerol kinase for rational drug discovery against African trypanosomiasis). 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集. 2015. 88回・38回. [2P0488]-[2P0488]
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Michio Murata, Shigeru Sugiyama, Shigeru Matsuoka, Nobuaki Matsumori. Bioactive Structure of Membrane Lipids and Natural Products Elucidated by a Chemistry-Based Approach. CHEMICAL RECORD. 2015. 15. 4. 675-690
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松岡 茂. 脂肪酸結合タンパク質の分子認識. BIO Clinica. 2015. 30. 77-82
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Patents (6)：
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Antifibrotic Compounds for the Treatment of Fibrosis
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Substituted tricyclic heterocyclic compounds as medicines for treating or preventing COVID-19
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Heterocycloalkyl-substituted polyheteroazole derivative as medical drug for treatment and/or prevention of rs virus infectious disease
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Cyclic amide compounds for rabies treatment and method thereof
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Compound for treatment of rabies and method therefor
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Education (4)：
- 1999 - 2003 Osaka University Graduate School of Science Department of Chemistry
- 1997 - 1999 The University of Tokyo Graduate School of Science Department of Chemistry
- 1995 - 1997 The University of Tokyo Faculty of Science Department of Chemistry
- 1993 - 1995 The University of Tokyo College of Arts and Sciences Science II
Professional career (1)：
Work history (8)：
- 2021/07 - 現在 Oita University Faculty of Medicine Specially Appointed Professor
- 2021/04 - 現在 Albius Sciences Ltd. Co-founder & Chief Technology Officer
- 2018/04 - 2021/06 Oita University Faculty of Medicine Specially Appointed Associate Professor
- 2017/04 - 2018/03 The University of Tokyo Graduate School of Medicine Project Associate Professor
- 2016/04 - 2017/03 The University of Tokyo Graduate School of Medicine Researcher
- 2011/10 - 2016/03 Osaka University Graduate School of Science Project Associate Professor
- 2007/06 - 2011/09 The University of Tokyo Graduate School of Pharmaceutical Science Assistant Professor
- 2005/03/01 - 2007/05/31 Washington University in St. Louis Department of Chemistry Research Associate
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Awards (2)：
- 2011/03 - 日本薬学会奨励賞
- 2004/07 - 天然物化学談話会奨励賞
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