Ogasawara Yasushi

オガサワラヤスシ | Ogasawara Yasushi

Affiliation and department：

Research field (1)： Bioorganic chemistry

Research keywords (2)： Biosynthesis , Natural Product Chemistry

Research theme for competitive and other funds (6)：

2022 - 2027 Enhancing the diversity of peptides by amino acids with reactive functional groups
2022 - 2027 Dissecting biosynthetic machineries of natural peptides leading to structural and functional diversities.
2023 - 2026 生理活性天然物の生合成に関わる三員環構築酵素の精密解析
2018 - 2021 Analysis of new peptide epimerases for the biosynthesis of peptide natural products
2016 - 2018 Exploring and functional analysis of peptide ligase orthologs

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Papers (61)：

Takeshi Tsunoda, Shunkichi Furumura, Haruka Yamazaki, Chitose Maruyama, Yoshimitsu Hamano, Yasushi Ogasawara, Tohru Dairi. Biosynthesis of lactacystin as a proteasome inhibitor. Communications chemistry. 2025. 8. 1. 9-9
Ning Shen, Yasuharu Satoh, Daisuke Koma, Hiroyuki Ohashi, Yasushi Ogasawara, Tohru Dairi. Optimization of tyrosol-producing pathway with tyrosine decarboxylase and tyramine oxidase in high-tyrosine-producing Escherichia coli. Journal of Bioscience and Bioengineering. 2024. 137. 2. 115-123
Shuhei Umetsu, Takeshi Tsunoda, Haruka Kiyanagi, Yuki Inahashi, Kenichi Nonaka, Tohru Dairi, Yasushi Ogasawara. Identification of a new oligomycin derivative as a specific inhibitor of the alternative peptidoglycan biosynthetic pathway. The Journal of antibiotics. 2024
Hinata Kato, Moeka Sakuta, Takeshi Tsunoda, Yu Nakashima, Hiroyuki Morita, Yasushi Ogasawara, Tohru Dairi. Peptide Epimerase Responsible for d-Amino Acid Introduction in Poly-γ-glutamic Acid Biosynthesis. Biomacromolecules. 2023. 25. 1. 349-354
Wanlu Xiao, Takeshi Tsunoda, Chitose Maruyama, Yoshimitsu Hamano, Yasushi Ogasawara, Tohru Dairi. Peptide epimerase-dehydratase complex responsible for biosynthesis of the linaridin class ribosomal peptides. Bioscience, biotechnology, and biochemistry. 2023. 87. 11. 1316-1322

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MISC (51)：

尾形海斗, 仲間陸, 小林飛悠, 角田毅, 丸山千登勢, 濱野吉十, 氏原哲朗, 小笠原泰志, 大利徹. Dissecting Ketosynthase Domains in Microalgal Polyunsaturated Fatty Acid Synthase. 日本農芸化学会大会講演要旨集(Web). 2024. 2024
川田智哉, 小林飛悠, 大塚慎, 角田毅, 丸山千登勢, 濱野吉十, 氏原哲朗, 小笠原泰志, 大利徹. Dissecting Dehydratase Domains in Microalgal Polyunsaturated Fatty Acid Synthase. 日本農芸化学会大会講演要旨集(Web). 2024. 2024
高橋佑大, 角田毅, 小笠原泰志, 大利徹. Biosynthetic Study of Antitumor Antibiotic Mitomycins. 日本農芸化学会大会講演要旨集(Web). 2024. 2024
西田壮吾, 成冨駿, 小倉勇輝, 山崎陽香, 角田毅, 勝山陽平, 勝山陽平, 小笠原泰志, 大利徹. Studies on biosynthesis of hydrazide-containing natural product. 日本農芸化学会大会講演要旨集(Web). 2024. 2024
梅澤朱理, 角田毅, 新宅一平, 小笠原泰志, 大利徹. Identification of Novel GTP Cyclohydrolase with Genome Mining. 日本農芸化学会大会講演要旨集(Web). 2024. 2024

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Professional career (1)：

Work history (3)：

2021/01 - 現在 Hokkaido University Faculty of Engineering Associate Professor
2014/04 - 2020/12 Hokkaido University Faculty of Engineering
2013/01 - 2014/03 The University of New Mexico Department of Chemistry and Chemical Biology Research Assistant Professor

Committee career (1)：

Awards (5)：

2024/06 - 天野エンザイム科学技術振興財団第25回酵素応用シンポジウム研究奨励賞ペプチドにD体アミノ酸を導入する新規異性化酵素の精密解析とその応用
2021/03 - Japan Society for Bioscience, Biotechnology, and Agrochemistry Hot Topics Award Epimerase involved in polyglutamic acid biosynthesis
2019/03 - 日本農芸化学会トピックス賞 in vitro解析による多価不飽和脂肪酸生合成酵素の炭素鎖長制御機構の解明
2018/03 - 日本農芸化学会奨励賞ペプチドの構造に多様性を与える新規酵素の探索
2017/03 - Japan Society for Bioscience, Biotechnology, and Agrochemistry Hot Topics Award An unprecedented glutamate epimerase for bacterial peptidoglycan biosynthesis

Association Membership(s) (3)：

The Society for Biotechnology, Japan , SOCIETY FOR ACTINOMYCETES JAPAN , JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY

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