Research theme for competitive and other funds (11):
2024 - 2028 アマトキシンの構造多様化機構の解明と構造展開への応用
2023 - 2025 糸状菌由来新規酸化酵素ファミリーの機能開拓
2022 - 2025 ゲノムマイニングによる糸状菌由来ペプチド系天然物の開拓
2019 - 2022 Exploring new biologically active metabolites using unidentified gene clusters from Basidiomycota genomes
2019 - 2022 Studies on the biosyntheses of fungal dimeric anhydrides
2019 - 2021 植物病原菌が生産するペプチド系化合物の構造多様性創出機構の解析
2017 - 2019 麹菌異種発現系を用いた感染時特異的な糸状菌代謝産物の安定供給
2017 - 2019 糸状菌リボソームペプチドの生合成に普遍的な新規環化酵素の機能解明
2014 - 2015 Studies on the mechanism of action of goadsporin and generation of new derivatives
2013 - 2013 Studies on the mechanism for goadsporin resistance
2010 - 2012 新規プレニル基転移酵素の機能解析と有用化合物創製への応用
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Papers (62):
Soya Koremura, Akihiro Sugawara, Yohei Morishita, Taro Ozaki, Teigo Asai. Semi-synthesis of a DNA-Tagged Polyketide-Peptide Hybrid Macrocycle Using a Biosynthetically Prepared Fungal Macrolide as a Synthetic Component. Organic Letters. 2024
Teruhito Kato, Dan Xia, Taro Ozaki, Tomoyo Nakao, Ping Zhao, Makoto Nishiyama, Taro Shiraishi, Tomohisa Kuzuyama. In vivo and in vitro reconstitution of biosynthesis of N-prenylated phenazines revealing diverse phenazine-modifying enzymes. Chembiochem : a European journal of chemical biology. 2024. e202400723
Takuya Katayama, Yulu Jiang, Taro Ozaki, Hideaki Oikawa, Atsushi Minami, Jun-Ichi Maruyama. Subcellular compartmentalized localization of transmembrane proteins essential for production of fungal cyclic peptide cyclochlorotine. Bioscience, biotechnology, and biochemistry. 2024
Yoshiro Sato, Xinge Shi, Ying Ye, Saori Domon, Junya Takino, Taro Ozaki, Chengwei Liu, Hideaki Oikawa, Atsushi Minami. Bioinformatics-Guided Reconstitution of Biosynthetic Machineries of Fungal Eremophilane Sesquiterpenes. ACS Chemical Biology. 2024
Fumito Sato, Terutaka Sonohara, Shunta Fujiki, Akihiro Sugawara, Yohei Morishita, Taro Ozaki, Teigo Asai. Genome mining of labdane-related diterpenoids: Discovery of the two-enzyme pathway leading to (-)-sandaracopimaradiene in the fungus Arthrinium sacchari. Beilstein Journal of Organic Chemistry. 2024
根岸透子, 尾崎太郎, 菅原章公, 森下陽平, 浅井禎吾. Heterologous production of the amatoxin precursor in Aspergillus oryzae. 日本薬学会年会要旨集(Web). 2024. 144th
岡本春太, 尾崎太郎, 森下陽平, 菅原章公, 浅井禎吾. Functional analysis of UstYa family proteins in the biosynthesis of cyclochlorotine derivatives. 日本薬学会年会要旨集(Web). 2024. 144th
長谷川智哉, 森下陽平, 菅原章公, 尾崎太郎, 浅井禎吾. Genome mining-based discovery of resorcinolic macrolides from Cytospora sp. 日本薬学会年会要旨集(Web). 2024. 144th
惟村壮哉, 菅原章公, 森下陽平, 尾崎太郎, 浅井禎吾. Synthesis of polyketide-peptide hybrid-like macrocyclic compounds on DNA aimed at constructing DNA-encoded libraries. 日本薬学会年会要旨集(Web). 2024. 144th
関谷光留, 佐藤史都, 菅原章公, 森下陽平, 尾崎太郎, 浅井禎吾. Chemoenzymatic synthesis of the fluorinated dolabellane skeleton for expanding functional diversity. 日本薬学会年会要旨集(Web). 2024. 144th
2021/09 - 現在 Tohoku University Graduate School of Pharmaceutical Sciences
2016/04 - 2021/08 Hokkaido University Faculty of Science Department of Chemistry Assistant Progessor
2013/04 - 2016/03 The University of Tokyo
2010/04 - 2013/03 日本学術振興会 特別研究員(DC1)
Awards (3):
2023/03 - The Excellent Paper Award Published in Bioscience, Biotechnology, & Biochemistry Structure and biosynthesis of the ribosomal lipopeptide antibiotic albopeptins
2020/03 - The Excellent Paper Award Published in Bioscience, Biotechnology, & Biochemistry Biosynthetic study of conidiation-inducing factor conidiogenone: heterologous production and cyclization mechanism of a key bifunctional diterpene synthase
Association Membership(s) (5):
日本生薬学会
, THE CHEMICAL SOCIETY OF JAPAN
, SOCIETY OF ACTINOMYCETES JAPAN
, JAPAN SOCIETY FOR BIOSICENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY
, 日本薬学会