Tsutsuki Hiroyasu

Research field (1)： Bacteriology

Research keywords (2)： microbiology , bacteriology

Research theme for competitive and other funds (9)：

2023 - 2026 腸管出血性大腸菌毒素SubABの宿主獲得免疫破綻機構とその感染病態制御法の解明
2021 - 2024 Molecular mechanisms of inhibitory regulation of NLRP3 inflammasome by reactive sulfur species
2020 - 2023 腸管出血性大腸菌毒素SubABのレドックス活性化機構とその感染病態制御法の解明
2021 - 2023 活性窒素種による志賀毒素産生性大腸菌毒素SubABの毒性制御機構の解明
2019 - 2021 Mechanisms of intracellular bacterial killing induced by reactive sulfur species

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Papers (65)：

Yoshihiro Hara, Yoshifumi Baba, Eri Oda, Kazuto Harada, Kohei Yamashita, Tasuku Toihata, Keisuke Kosumi, Masaaki Iwatsuki, Yuji Miyamoto, Hiroyasu Tsutsuki, et al. Presence of Fusobacterium nucleatum in relation to patient survival and an acidic environment in oesophagogastric junction and gastric cancers. British journal of cancer. 2024. 131. 5. 797-807
Kazuya Ozaki, Hiyo Nagahara, Asaka Kawamura, Takashi Ohgita, Sachika Higashi, Kohei Ogura, Hiroyasu Tsutsuki, Sunao Iyoda, Atsushi Yokotani, Toshiyuki Yamaji, et al. Extracellular Vesicle Inhibitors Enhance Cholix-Induced Cell Death via Regulation of the JNK-Dependent Pathway. Toxins. 2024. 16. 9. 380-380
Xiaoyan Li, Touya Toyomoto, Tianli Zhang, Chunyu Guo, Stephen Lindahl, Hiroyasu Tsutsuki, Ming Xian, Tomohiro Sawa. Supersulfides suppress type-I and type-II interferon responses by blocking JAK/STAT signaling in macrophages. International immunology. 2024
Hiroyasu Tsutsuki, Tianli Zhang, Takaaki Akaike, Tomohiro Sawa. Regulation of innate immune and inflammatory responses by supersulfides. International immunology. 2024
Hiroyasu Tsutsuki, Tianli Zhang, Tomohiro Sawa. [Redox Biology Involved in the Toxicity of Enterohemorrhagic Escherichia coli Toxin SubAB]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 2024. 144. 1. 57-60

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MISC (41)：

ラハマンアジズール, 張田力, 津々木博康, 小野勝彦, 宮野佳, 山内明, 赤池孝章, 澤智裕. Enhanced capability of bacteria killing by polysulfide donor in immune cells. 日本酸化ストレス学会学術集会プログラム・抄録集. 2021. 74th (CD-ROM)
松永哲郎, 吉田真彰, 西村明, 守田匡伸, 井田智章, 津々木博康, 澤智裕, 本橋ほづみ, 河村好章, 赤池孝章. Latent infection of Helicobacter cinaedi in bone marrow sustained by super sulfide. 日本細菌学雑誌(Web). 2021. 76. 1
小野勝彦, 津々木博康, ZHANG Tianli, 井原敏博, 赤池孝章, 澤智裕. Physiological role of b-lactam inactivation mediated by cysteine in redox-dependent manner. 日本細菌学雑誌(Web). 2020. 75. 1
張田力, 津々木博康, 小野勝彦, 赤池孝章, 澤智裕. Glutathione attenuates IL-1 β production in mice via inhibiting NLRP3 inflammasome activation. 日本NO学会学術集会プログラム抄録集. 2019. 19th. 50
松永哲郎, 西村明, 守田匡伸, 井田智章, 津々木博康, 澤智裕, 河村好章, 赤池孝章. 新興感染症菌Helicobacter cinaediの骨髄内の潜伏感染と細胞内寄生性の分子機構の解明. 日本細菌学雑誌. 2019. 74. 1. 104-104

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Professional career (1)：

Work history (3)：

2023/03 - 現在熊本大学大学院生命科学研究部微生物学講座講師
2015 - Assistant Professor,Faculty of Life Sciences(Basic medicine group),Kumamoto University
2014/11 - Kumamoto University Faculty of Life Sciences

Awards (2)：

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