RIKEN
center of Integrative Medical Sciences, Laboratory for Human Disease Models
Visiting researcher
Research field (1)：
Immunology
Research theme for competitive and other funds (5)：
2022 - 2025 急性骨髄性白血病治療に特化したCXCR4発現CD25標的キメラT細胞の解析
2019 - 2022 Functional elucidation of transcription factor Bach2 in the development and maintenance of acute myeloid leukemia
2017 - 2019 Elucidation of the acquisition mechanism of a long life in plasma cells
2015 - 2017 A Bach2-Cebp gene regulatory network for the commitment of multipotent hematopoietic progenitors
2015 - 2017 Regulation of lineage fate in hematopoietic stem cells by Bach2(Fostering Joint International Research)
Papers (46)：
Mei-Tzu Su, Masanori Inui, Yi Li Wong, Maika Takahashi, Akiko Sugahara-Tobinai, Karin Ono, Shotaro Miyamoto, Keiichi Murakami, Ari Itoh-Nakadai, Dai Kezuka, et al. Blockade of checkpoint ILT3/LILRB4/gp49B binding to fibronectin ameliorates autoimmune disease in BXSB/Yaa mice. International immunology. 2021. 33. 8. 447-458
Miura Y, Morooka M, Sax N, Roychoudhuri R, Itoh-Nakadai A, Brydun A, Funayama R, Nakayama K, Satomi S, Matsumoto M, et al. Bach2 Promotes B Cell Receptor-Induced Proliferation of B Lymphocytes and Represses Cyclin-Dependent Kinase Inhibitors. Journal of immunology (Baltimore, Md. : 1950). 2018. 200. 8. 2882-2893
Ari Itoh-Nakadai, Atsuko Kayaba, Toshiyuki Takai. Secretory leukocyte peptidase inhibitor (SLPI) is highly expressed in long-lived plasma cells. CYTOKINE. 2017. 100. 166-166
Targeting poor prognosis acute myeloid leukemia with CD25-targeted chemokine receptor expressing CAR T cell therapy
(The 51st Annual Meeting of the Japanese Society for Immunology 2022)
CXCR4-Expressing Anti-CD25 CAR T-Cells Effectively Eliminate Human AML Cells In Vivo
(Blood 2020)
Professional career (1)：
Ph.D (Tohoku University)
Awards (6)：
2021/12 - Best presentation award Targeting poor prognosis leukemia with CD25-targeted chemokine receptor expressing CAR Tcell therapy
2019/12 - The Japanese Society for Immunology Best Presentation Award Creation of HLA class I and class II Tg NOD/SCID/Il2rgKO (NSG) mice for studying interaction between human immunity and leukemia
2015/12 - The Japanese Society for Immunology Best Presentation Award Bach2 represses myeloid programs to promote lymphoid progenitor development under both the steady state and infection
2015/10 - International Immunological Memory and Vaccine Forum (IIMVF) Travel award for Young Scientists -
2015/03 - The Elkes foundation Keystone Symposia Future of science fund, National institution of allergy and infection diseases (NIAID) -
