Du Cheng-Kun

Affiliation and department：
Job title：上級研究員

Research field (3)： Physiology , Pharmacology , Cardiology

Research keywords (10)：トランスレーショナルリサーチ , 遺伝子突然変異 , カルシウムシグナリング , 遺伝性心筋症 , 突然死 , トロポニン , カルシウム感受性 , ノックインモデル , 心不全 , 心臓自律神経

Research theme for competitive and other funds (6)：

2019 - 2023 Influence of non-vascular cells in accelerated coronary aging in diabetes
2019 - 2022 肥大型心筋症の病態形成における心筋エネルギー代謝異常の役割の解明と治療薬の検討
2016 - 2019 ノックインマウスを用いたヒト遺伝性心筋症の病態形成メカニズム解明と治療薬の検討
2016 - 2018 Synchrotron radiation investigation of cardiac contractile protein dynamics at end diastole in a type 2 prediabetes model rat
2012 - 2015 肥大型心筋症の発症機序解明と治療法開発に関する基礎研究

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Papers (27)：

James T Pearson, Hamish P Thambyah, Mark T Waddingham, Tadakatsu Inagaki, Vijayakumar Sukumaran, Jennifer P Ngo, Connie P C Ow, Takashi Sonobe, Yi Ching Chen, Amanda J Edgley, et al. β-blockade prevents coronary macro- and microvascular dysfunction induced by a high salt diet and insulin resistance in the Goto-Kakizaki rat. Clinical science (London, England : 1979). 2021. 135. 2. 327-346
James Pearson, Hamish P Thambyah, Mark T Waddingham, Tadakatsu Inagaki, Vijayakumar Sukumaran, Jennifer P Ngo, Connie Pc Ow, Takashi Sonobe, Yi Ching Chen, Amanda J Edgley, et al. Beta-blockade Prevents Coronary Macro and Microvascular Dysfunction Induced by a High Salt Diet and Insulin Resistance in the Goto-Kakizaki Rat. Clinical science (London, England : 1979). 2021
Toshihide Kashihara, Hiroyuki Kawagishi, Tsutomu Nakada, Takuro Numaga-Tomita, Shin Kadota, Elena E Wolf, Cheng-Kun Du, Yuji Shiba, Sachio Morimoto, Mitsuhiko Yamada. β-Arrestin-Biased AT1 Agonist TRV027 Causes a Neonatal-Specific Sustained Positive Inotropic Effect Without Increasing Heart Rate. JACC. Basic to translational science. 2020. 5. 11. 1057-1069
Jason Kar-Sheng Lew, James T. Pearson, Eugene Saw, Hirotsugu Tsuchimochi, Melanie Wei, Nilanjan Ghosh, Cheng-Kun Du, Dong-Yun Zhan, Meihua Jin, Keiji Umetani, et al. Exercise Regulates MicroRNAs to Preserve Coronary and Cardiac Function in the Diabetic Heart. Circulation Research. 2020. 1384-1400
Sonobe T, Akiyama T, Du CK, Pearson JT. Serotonin uptake via plasma membrane monoamine transporter during myocardial ischemia-reperfusion in the rat heart in vivo. Physiol Rep. 2019. 7. 22

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MISC (34)：

秋山剛, 清水秀二, 杜成坤, 戦冬雲, 稲垣董克, 吉本光佐, 曽野部崇, 川田徹, ピアソンジェームズ. 心臓マイクロダイアリシス法の利点. Circ Cont. 2017. 38. 208-217
DongYun Zhan, ChengKun Du, Tsuyoshi Akiyama, Sachio Morimoto, Shuji Shimizu, Toru Kawada, Mikiyasu Shirai, James T. Pearson. Cardiac Vagal Control in Knock-in Mouse model of Dilated Cardiomyopathy. CIRCULATION. 2016. 134
DongYun Zhan, ChengKun Du, Tsuyoshi Akiyama, Sachio Morimoto, Shuji Shimizu, Toru Kawada, Mikiyasu Shirai, James T. Pearson. Cardiac Vagal Control in Knock-in Mouse model of Dilated Cardiomyopathy. CIRCULATION. 2016. 134
戦冬雲, 杜成坤, 森本幸生, 秋山剛, Schwenke Daryl O, 細田洋司, 寒川賢治, 白井幹康, James Person. 遺伝性拡張型心筋症に対する新規治療法の開発に向けて. BIO Clinica. 2016. 31. 6. 647-650
戦冬雲, 杜成坤, 森本幸生, 秋山剛, Daryl O. Schwenke, 細田洋司, 寒川賢治, 白井幹康, Pearson James. 遺伝性拡張型心筋症に対する新規治療法の開発に向けて. BIO Clinica. 2016. 31. 6. 101-104

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Books (1)：

心筋ミオフィラメントCa感受性.
日本臨牀 2018

Education (1)：

2003 - 2007 Kyushu University Faculty of Medical Sciences

Professional career (1)：

医学博士 (九州大学)

Association Membership(s) (4)：

BIOPHYSICAL SOCIETY , 日本心血管内分泌代謝学会 , 日本薬理学会 , 日本生理学会

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