Hirayama Hiroto

ヒラヤマヒロト | Hirayama Hiroto

Affiliation and department：
Job title：研究員
Homepage URL (1)： https://kaken.nii.ac.jp/d/r/50525847.ja.html

Research field (2)： Molecular biology , Functional biochemistry

Research keywords (14)： Protein quality control system , exploring biomarkers , glycan , Glycobiology , NGLY1 deficiency , PNGase , iPS cells , Rare disease , NGLY1 , 糖鎖代謝 , 遊離糖鎖解析 , 出芽酵母 , 遊離糖鎖 , 新規遺伝子探索

Research theme for competitive and other funds (9)：

2023 - 2024 ペプチド:N-グリカナーゼの持つレクチンドメインの基質特異性解析[R5-探3]
2022 - 2024 Study of the secretion capacity of protein in NGLY1 deficient cell
2016 - 2018 新規エンドO-マンノシダーゼの同定 -新たな脱糖鎖ツ-ルの開発に向けて-
2013 - 2017 Clarification of molecular mechanism for the catabolism of glycans on glycoproteins in budding yeast
2015 - 2016 出芽酵母が持つ新規エンド O-マンノシダーゼの同定とその機能解析

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Papers (27)：

Hiroto Hirayama, Haruhiko Fujihira, Tadashi Suzuki. Development of new NGLY1 assay systems - toward developing an early screening method for NGLY1 deficiency. Glycobiology. 2024
Hiroto Hirayama, Yuriko Tachida, Reiko Fujinawa, Yuka Matsuda, Takefumi Murase, Yuji Nishiuchi, Tadashi Suzuki. Development of a Fluorescence and Quencher-based FRET Assay for Detection of Endogenous Peptide:N-glycanase/NGLY1 Activity. The Journal of biological chemistry. 2024. 300. 4. 107121
Sheng-Tao Li, Hiroto Hirayama, Chengcheng Huang, Tsugiyo Matsuda, Ritsuko Oka, Takahiro Yamasaki, Daisuke Kohda, Tadashi Suzuki. Hydrolytic activity of yeast oligosaccharyltransferase is enhanced when misfolded proteins accumulate in the endoplasmic reticulum. The FEBS Journal. 2023. 291. 5. 884-896
Yuriko Tachida, Hiroto Hirayama, Tadashi Suzuki. Amino acid editing of NFE2L1 by PNGase causes abnormal mobility on SDS-PAGE. Biochimica et Biophysica Acta (BBA) - General Subjects. 2023. 1867. 12. 130494-130494
Huang S, Haga Y, Li J, Zhang J, Kweon HK, Seino J, Hirayama H, Fujita M, Moremen KW, Andrews P, et al. Mitotic phosphorylation inhibits the Golgi mannosidase MAN1A1. Cell Rep . 2022. 41. 8. 111679-111679

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MISC (1)：

Yanzhuang Wang, Shijiao Huang, Yoshimi Haga, Hye Kyong Kyong Kweon, Hiroto Hirayama, Philip Andrews, Tadashi Suzuki. Glycosylation quality control by the Golgi structure. FASEB JOURNAL. 2017. 31

Patents (1)：

細胞溶解物中のNGLY1活性を測定する方法及びそれに用いられるプローブ

Books (1)：

Handbook of glycosyltransferases and related genes (Springer Japan), pp. 1599-1606,
Springer Japan 2013

Lectures and oral presentations (39)：

細胞質Peptide:N-glycanaseが持つ非触媒ドメインの機能についての再検証
(第97回日本生化学会大会(パシフィコ横浜) 2024)
NGLY1非依存的な細胞質糖鎖代謝経路についての解析
(第46回日本生化学会大会 2023)
NGLY1非依存的な細胞質糖鎖代謝経路についての解析
(第46回日本生化学会大会 2023)
FRET型プローブを用いた細胞内在性ペプチド:N-グリカナーゼ活性測定法の開発
(第42回日本糖質学会年会 2023)
Establishment of a method for measuring the endogenous peptide:N-glycanase activity using a novel FRET-based probe
(Glyco26 2023)

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Education (2)：

2005 - 2008 University of Tsukuba
2003 - 2005 University of Tsukuba

Professional career (1)：

博士 (理学) (筑波大学)

Work history (5)：

2018/04 - 現在 RIKEN
2017/02 - 2024/03 T-CiRA NGLY1-deficiency project (Suzuki PJ) Sub-PI
2017/02 - 2018/03 京都大学iPS細胞研究所湘南分室 (山中研究室) 特任助教
2012/04 - 2017/03 RIKEN
2008/04 - 2012/03 独立行政法人理化学研究所基幹研究所ケミカルバイオロジー研究部門システム糖鎖生物学研究グループ糖鎖代謝学研究チーム特別研究員

Awards (5)：

2023/07 - The Japanese Biochemical Society JB reviewer award
2015 - 野田産研野田産研研究助成
2013 - 酵母細胞研究会地神芳文記念研究助成
2011 - Society for Glycobiology Travel award
2008 - Journal of Biochemistry award

Association Membership(s) (3)：

THE JAPANESE SOCIETY OF CARBOHYDRATE RESEARCH , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , THE JAPANESE BIOCHEMICAL SOCIETY

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