Yuta Ishizuka

イシヅカユウタ | Yuta Ishizuka

Affiliation and department：
Job title： Lecturer

Research field (4)： Molecular biology , Pathobiochemistry , Cell biology , Neuroscience - general

Research keywords (6)： Saposin , Glycosphingolipid , Lysosomal storage disease , Metabolic disorder , Neurodegenerative disorder , Synaptic plasticity

Research theme for competitive and other funds (6)：

2024 - 2026 Pax3遺伝子へのレトロトランスポゾンの挿入が神経管閉鎖不全を引き起こすメカニズムの解明
2022 - 2025 Elucidation of novel functions of prosaposin in autophagy
2022 - 2023 網膜色素変性症の発症機序をオートファジーの破綻という観点から探る
2022 - 2023 網膜色素変性症の新規モデルマウスとなり得るプロサポシン過剰発現マウスの解析
2015 - 2016 Study for the mechanisms of intercellular signaling of glial cells in the central nervous system

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Papers (29)：

Tambudzai Kanhema, Kamil Parobczak, Sudarshan Patil, Dagmara Holm-Kaczmarek, Erik Hallin, Jan Ludwiczak, Andrzej A. Szczepankiewicz, Francois P. Pauzin, Adrian Szum, Yuta Ishizuka, et al. Arc/Arg3.1 binds the nuclear polyadenylate-binding protein RRM and regulates neuronal activity-dependent formation of nuclear speckles. 2024
Rodolfo Baldinotti, Francois P. Pauzin, Hauk Fevang, Yuta Ishizuka, Clive R. Bramham. A nanobody-based proximity ligation assay detects constitutive and stimulus-regulated native Arc/Arg3.1 oligomers in hippocampal neuronal dendrites. Molecular neurobiology. 2024. in press
Takashi Watanabe, Kazuhito Tsuboi, Nobuaki Matsuda, Yuta Ishizuka, Shinji Go, Etsuko Watanabe, Ayaka Ono, Yasuo Okamoto, Junko Matsuda. Genetic ablation of Saposin-D in Krabbe disease eliminates psychosine accumulation but does not significantly improve demyelination. Journal of Neurochemistry. 2023. 166. 4. 720-746
Tadiwos F. Mergiya, Jens E. Gundersen, Tambudzai Kanhema, Grant M. Brighter, Yuta Ishizuka, Clive R. Bramham*. Detection of Arc/Arg3.1 oligomers in rat brain: constitutive and synaptic activity-evoked dimer expression in vivo. Frontiers in Molecular Neuroscience. 2023. 16. 1142361
Takashi Watanabe, Akemi Suzuki, Shin Ohira, Shinji Go, Yuta Ishizuka, Takuya Moriya, Yoshiyuki Miyaji, Tota Nakatsuka, Keita Hirata, Atsushi Nagai, et al. The Urinary Bladder is Rich in Glycosphingolipids Composed of Phytoceramides. Journal of lipid research. 2022. 63. 12. 100303

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MISC (10)：

Tomoaki Shirao, Yuta Ishizuka, Hideo Shimizu, Yuko Sekino. Search for the anti-amyloid beta drugs using primary neuronal cultures with drebrin cluster density as a marker of synaptic function. JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS. 2015. 75. 171-171
Y. Ishizuka, H. Shimizu, T. Shirao. Histone deacetylase mediates drebrin loss from dendritic spines induced by amyloid beta oligomers. JOURNAL OF NEUROCHEMISTRY. 2015. 134. 273-274
Yuta Ishizuka, Hideo Shimizu, Eiko Takagi, Mai Kato, Masahiko Mikuni, Tomoaki Shirao. Synapse vulnerability induced by Amyloid beta-derived diffusible ligands is blocked by the inhibitor of histone deacetylase. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2014. 124. 151P-151P
Y. Ishizuka, H. Shimizu, E. Takagi, T. Shirao. Histone deacetylase (HDAC) inhibitor attenuates the effect of Amyloid beta on dendritic spine function. JOURNAL OF NEUROCHEMISTRY. 2013. 125. 236-237
H. Shimizu, E. Takagi, Y. Ishizuka, T. Shirao. Histone deacetylase (HDAC) inhibitor protects synaptic function against amyloid beta oligomer. JOURNAL OF NEUROCHEMISTRY. 2012. 123. 82-82

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Books (2)：

Drebrin in Alzheimer’s Disease,Drebrin
Springer 2017 ISBN:9784431565482
AUTONOMIC DRUGS,Katzung & Trevor’s Pharmacology Examination & Board Review 9th edition
MARUZEN PUBLISHING 2012 ISBN:9784621084700

Lectures and oral presentations (26)：

Selective Degeneration of Retinal Photoreceptor Cell in Prosaposin Transgenic Mice
(The 64th Annual Meeting of the Japanese Society for Inherited Metabolic Diseases 2023)
Degeneration of Retinal Photoreceptor Cell in Prosaposin Transgenic Mice
(The 64th Anual Meeting of the Japanese Society of Neuropathology / The 66th Annual Meeting of the Japanese Society for Neurochemistry 2023)
Establishment of cryopreserved neuronal cell bank -Analysis of Saposin D mutant neuron-
(The 63nd Annual Meeting of the Japanese Society for Inherited Metabolic Diseases 2022)
Development and validation of Arc nanobodies: new tools for probing Arc dynamics and function
(NEURO2022 2022)
A simple DMSO-based method for cryopreservation of primary hippocampal and cortical neurons
(The 12th Federation of European Neuroscience Societies Forum. 2020)

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Professional career (3)：

Bachelor of Science (Niigata University)
Master of Life Science (Niigata University)
Ph.D. in Medicine (Niigata University)

Work history (3)：

2021/07 - 現在 Kawasaki Medical School Department of Pathophysiology and Metabolism Lecturer
2017/04 - 2021/05 University of Bergen Department of Biomedicine Researher Postdoc
2011/04 - 2017/03 Gunma University Graduate School of Medicine, Department of Neurobiology and Behavior Assistant Professor

Committee career (5)：

2019 - 現在 frontiers in Molecular Neurosciene Review editor
2015 - 2017 International Society for Neurochemistry (ISN) Young Scientist’s Steering Committee
2015 - 2017 日本神経化学会(JSN) 国際対応委員
2015 - 2017 The Japanese Society for Neurochemistry (JSN) Future Planning Committee
2015 - 2016 The Japanese Society for Neurochemistry (JSN) Program Committee

Awards (9)：

2024 - BioLegend/Tomy Digital Biology LEGEND Research Grant Program 2023(後期) 第一位
2019 - University of Bergen [Best Image Award (Biomedical Image Contest @Department of Biomedicine)]
2018 - K.G. Jebsen Center for Neuropsychiatric Disorders [Poster Prize (Annual Retreat 2018)]
2018 - University of Bergen [Best Poster Award (Poster contest @Department of Biomedicine)]
2013 - International Society for Neurochemistry [Travel Award (The 24th Biennial Meeting of ISN-ASN]

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Association Membership(s) (3)：

the Japanese Society for Inherited Matabolic Diseases , The Japan Neuroscience Society , The Japanese Society for Neurochemistry

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