Rchr
J-GLOBAL ID：201601003037501967   Update date: Nov. 18, 2024

TAKEDA SHIGEKI

TAKEDA SHIGEKI
Affiliation and department：
Gunma University

About Gunma University


Research field  (1)： Molecular biology
Research keywords  (7)： Protein, Receptor, Bacteriophage, Self-assembly, interaction ,  分子間相互作用 ,  自律的形態形成 ,  バクテリオファージ ,  Gタンパク質共役受容体 ,  新規リガンド検索 ,  トランスジェニックカイコ
Research theme for competitive and other funds  (15)：
  • 2018 - 2022 Epigenetic modulation by chemical substances on thyroid hormone-mediated brain development.
  • 2014 - 2017 Biochemical preparation of isotpe-labelled lipopolysaccharide and nmr analysis of host recognition mechanism of phage
  • 2012 - 2015 Structural study of bacteriophage Mu
  • 2009 - 2011 Identification of peptide ligands for lipid receptors
  • 2008 - 2009 バクテリオファージMuを構成するサブユニットの構造解析
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Papers (161)：
  • Yuduki Someya, Shinta Saito, Shigeki Takeda, Noritaka Adachi, Aya Kurosawa. Quercetin exhibits cytotoxicity in cancer cells by inducing two-ended DNA double-strand breaks. Biochemical and Biophysical Research Communications. 2024. 739. 150977-150977
  • Momoka Horikawa, Kei Masuda, Hideyuki Takahashi, Hiroe Tada, Yuichi Tomidokoro, Masaomi Motegi, Tetsunari Oyama, Shigeki Takeda, Kazuaki Chikamatsu. Tumor antigen-specific interleukin-10-producing T-cell response in patients with head and neck squamous cell carcinoma. Oncology Letters. 2024
  • Kazuaki Chikamatsu, Shota Ida, Kei Masuda, Momoka Horikawa, Nanami Hoshino, Hideyuki Takahashi, Hiroe Tada, Tetsunari Oyama, Shigeki Takeda, Yuichi Tomidokoro, et al. Enhancement of Tumor Antigen-specific T-cell Responses by Immune Checkpoint Blockade in Human Papillomavirus-related Head and Neck Squamous Cell Carcinoma. Anticancer research. 2024. 44. 7. 2921-2931
  • Yukina Mori, Eiki Yamashita, Atsushi Nakagawa, Tomoki Matsuzawa, Minoru Inagaki, Yoshifumi Aiba, Syu Tanaka, Syunya Hatori, Maeda Ayami, Shigeki Takeda. Determination of the three-dimensional structure of bacteriophage Mu(-) tail fiber and its characterization. Virology. 2024. 593. 110017-110017
  • Yuduki Someya, Sakine Kobayashi, Kazuya Toriumi, Shigeki Takeda, Noritaka Adachi, Aya Kurosawa. A Cell System-Assisted Strategy for Evaluating the Natural Antioxidant-Induced Double-Stranded DNA Break (DSB) Style. Genes. 2023. 14. 2
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MISC (23)：
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Patents (5)：
  • GPR119アゴニスト
  • 5-oxo-ETE受容体を活性化するペプチドとその誘導体
  • 5-oxo-ETE受容体タンパク質及びその遺伝子
  • COMPLEX CONTAINING PROTEIN WITH LIGAND BINDING CAPACITY, AND METHOD OF SCREENING SUBSTANCE CAPABLE OF BINDING TO PROTEIN WITH LIGAND BINDING CAPACITY
  • リガンド結合タンパク質含有複合体及びリガンド結合タンパク質に結合する物質のスクリーニング方法
Books (4)：
  • Observation of unexpected molecular binding activity for Mu phage tail fiber chaperones.
    Journal of biochemistry 2019
  • Three-dimensional structures of bacteriophage neck subunits are shared in Podoviridae, Siphoviridae and Myoviridae.
    2019
  • G protein-coupled receptors: Structure, function, and ligand screening
    CRC Press, Florida 2006
  • 物理生化学
    バイオサイエンス・シリーズ 2003
Lectures and oral presentations  (54)：
  • Characterization of Mu phage tube protein gp40 and its polymerization
    (The Molecular Biology Society of Japan 2013)
  • Identification of an intermediate complex for Mu phage baseplate assembly
    (The Molecular Biology Society of Japan 2013)
  • Purification and characterization of substances that enhance insulin secretion.
    (The Molecular Biology Society of Japan 2013)
  • バクテリオファージMu基盤サブユニットの発現と精製
    (分子生物学会 2012)
  • GPR61の恒常的活性化に関与するN末端アミノ酸配列の同定
    (分子生物学会 2012)
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Education (2)：
  • - 1991 The University of Tokyo Graduate School, Division of Engineering
  • - 1986 Hokkaido University Faculty of Pharmaceutical Science
Professional career (1)：
  • 工学博士 (東京大学)
Work history (1)：
  • Gunma University
Awards (1)：
  • 2008/02/01 - 横山科学技術賞
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