Sho Kubota

Affiliation and department：

Research field (3)： Pharmacology , Pharmaceuticals - health and biochemistry , Hematology and oncology

Research keywords (10)： NO , BPDCN , 造血幹細胞 , バイオインフォマティクス , 転写因子 , 細胞内シグナル伝達 , チロシンキナーゼ , 環境化学物質 , 白血病 , エピジェネティクス

Research theme for competitive and other funds (13)：

2024 - 2029 健康・老化・老人性疾患における酸化ストレス依存的エピゲノム変化の意義
2024 - 2028 Integrated understanding of the mechanisms of maintenance and breakdown of epigenomic resilience for health
2024 - 2027 Elucidation of the mechanism of epigenome dysregulation by environmental chemicals
2021 - 2024 MLL融合白血病発症を受容する胎児造血幹細胞形質の解析
2018 - 2021 Leukemic development through chromosomal translocation with super-enhancer exchange

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Papers (43)：

Haruna Kurogi, Nobumasa Takasugi, Sho Kubota, Ashutosh Kumar, Takehiro Suzuki, Naoshi Dohmae, Daisuke Sawada, Kam Y.J. Zhang, Takashi Uehara. Discovery of a Compound That Inhibits IRE1α S-Nitrosylation and Preserves the Endoplasmic Reticulum Stress Response under Nitrosative Stress. ACS Chemical Biology. 2024. 19. 12. 2429-2437
Tomoki Tsuchida, Sho Kubota, Shizuki Kamiuezono, Nobumasa Takasugi, Akihiro Ito, Yoshito Kumagai, Takashi Uehara. Epigenetic Regulation of CXC Chemokine Expression by Environmental Electrophiles Through DNA Methyltransferase Inhibition. International Journal of Molecular Sciences. 2024. 25. 21. 11592-11592
Ryohei Miki, Ryosuke Nomura, Yuta Iijima, Sho Kubota, Nobumasa Takasugi, Takao Iwawaki, Masatake Fujimura, Takashi Uehara. Therapeutic potential of 4-phenylbutyric acid against methylmercury-induced neuronal cell death in mice. Archives of Toxicology. 2024
Yuto Moriya, Sho Kubota, Yuta Iijima, Nobumasa Takasugi, Takashi Uehara. Epigenetic Regulation of Carbonic Anhydrase 9 Expression by Nitric Oxide in Human Small Airway Epithelial Cells. Biological and Pharmaceutical Bulletin. 2024. 47. 6. 1119-1122
Sho Kubota, Yuqi Sun, Mariko Morii, Jie Bai, Takako Ideue, Mayumi Hirayama, Supannika Sorin, Eerdunduleng, Takako Yokomizo-Nakano, Motomi Osato, et al. Chromatin modifier Hmga2 promotes adult hematopoietic stem cell function and blood regeneration in stress conditions. The EMBO Journal. 2024. 43. 13. 2661-2684

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MISC (4)：

指田吾郎, 横溝貴子, 久保田翔, 原田浩徳, 大里元美, 岩間厚志. Tet2欠損によるHmga2機能制御と骨髄異形成症候群発症の分子基盤(Tet2 loss reshapes Hmga2 binding regions to promote the development of myelodysplastic syndrome). 日本癌学会総会記事. 2019. 78回. E-2077
横溝貴子, 久保田翔, 岩間厚志, 原田浩徳, 大里元美, 指田吾郎. RUNX3発現による骨髄異形成症候群発症の分子基盤解明(RUNX3 over-expression impedes RUNX1 function and promotes the development of myelodysplastic syndrome). 日本癌学会総会記事. 2019. 78回. P-2224
Sho Kubota, Kenji Tokunaga, Tomohiro Umezu, Takako Yokomizo, Motohiko Oshima, Eisaku Iwanaga, Norio Asou, Atsushi Iwama, Kazuma Ohyashiki, Motomi Osato, et al. Lineage-Specific RUNX2 Super-Enhancer Activates MYC Via Translocation (6;8) to Promote the Development of Blastic Plasmacytoid Dendritic Cell Neoplasm. BLOOD (International Conference). 2018. 132
久保田翔, 梅津知宏, 岩間厚志, 大屋敷一馬, 大里元美, 指田吾郎. RUNX2スーパーエンハンサーによるMYCの活性化を介したBPDCNの発症メカニズムの解析(Lineage-specific RUNX2 super-enhancer activates MYC via a chromosomal translocation and promotes the BPDCN). 日本癌学会総会記事. 2018. 77回. 1966-1966

Education (3)：

Professional career (1)：

Work history (4)：

Committee career (3)：

Awards (5)：

Association Membership(s) (4)：

日本薬理学会 , 日本毒性学会 , 日本血液学会 , 日本薬学会

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