Uchimoto Kaede

ウチモトカエデ | Uchimoto Kaede

Affiliation and department：
Job title： Assistant Professor
Homepage URL (1)： http://www.med.niigata-u.ac.jp/nim/welcomej.html

Research field (1)： Nephrology

Research keywords (2)：実験病理学 , 腎臓病学

Research theme for competitive and other funds (8)：

2024 - 2028 スリット膜機能維持におけるNeurexin-シナプス小胞関連分子相互作用の役割
2022 - 2025 Role of Ephrin-Nephrin-Neurexin complex in maintaining slit diaphragm function
2020 - 2024 腎糸球体上皮細胞スリット膜におけるNeurexinの役割の解明
2019 - 2023 Function of TRPM4 on podocyte
2019 - 2022 Novel therapy for nephotic syndrome targetting synapse associated molecules in podocyte

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Papers (50)：

Hidenori Yasuda, Yoshiyasu Fukusumi, Ying Zhang, Hiroshi Kawachi. Cover Image. The FASEB Journal. 2023
Hidenori Yasuda, Yoshiyasu Fukusumi, Ying Zhang, Hiroshi Kawachi. 14-3-3 Proteins stabilize actin and vimentin filaments to maintain processes in renal glomerular podocyte. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2023. 37. 10. e23168
Hiroshi Kawachi, Yoshiyasu Fukusumi, Kaede Uchimoto. Podocyte injury in minimal change nephrotic syndrome. 2022. 15. 6. 644-651
Syuhei Watanabe, Ying Zhang, Yoshiyasu Fukusumi, Hidenori Yasuda, Akira Takada, Junichiro J Kazama, Hiroshi Kawachi. Th17 Cells Participate in Thy1.1 Glomerulonephritis Which Is Ameliorated by Tacrolimus. American journal of nephrology. 2022. 53. 5. 388-396
内許玉楓, 河内裕. プライマリ-カルチャー樹立法. 腎と透析. 2021. 91. 5. 965-969

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MISC (5)：

Hasegawa Miki, Kanbayashi Chizuko, Wakai Toshifumi, Tomonaga takeshi, Yamamoto tadashi, Yoshida Yutaka, Shiromizu Takashi, Sato Nobuaki, Zhang Ying, Koyama Yu, et al. Discoverry of predictive biomarkers for pre-surgical chemotherapy in ER-positive HER2-negative breast cancer. Abstracts for Annual Meeting of Japanese Proteomics Society. 2015. 2015. 0. 144-144
Masaaki Takamura, Bo Xu, Satoshi Yamagiwa, Yasunobu Matsuda, Shuichiro Shimada, Ying Zhang, Yutaka Yoshida, Eishin Yaoita, Minoru Nomoto, Tadashi Yamamoto, et al. Comparative proteomic analysis of the liver in a murine model of non-alcoholic steatohepatitis. HEPATOLOGY. 2012. 56. 855A-855A
Ying Zhang, Yutaka Yoshida, Masaaki Nameta, Bo Xu, Izumi Taguchi, Takako Ikeda, Hidehiko Fujinaka, Sameh Magdeldin, Hiroyasu Tsukaguchi, Yutaka Harita, et al. Glomerular proteins related to slit diaphragm and matrix adhesion in the foot processes are highly tyrosine phosphorylated in the normal rat kidney (vol 25, pg 1785, 2010). NEPHROLOGY DIALYSIS TRANSPLANTATION. 2012. 27. 6. 2606-2606
高村昌昭, 許波, 嶋田修一郎, 張瑩, 吉田豊, 矢尾板永信, 山際訓, 松田康伸, 野本実, 山本格, et al. 実験的NASHモデルマウス肝組織のプロテオーム解析. 日本消化器病学会雑誌. 2012. 109. 臨増総会. A325-A325
Yutaka Yoshida, Masahito Miyamoto, Izumi Taguchi, Bo Xu, Ying Zhang, Eishin Yaoita, Hidehiko Fujinaka, Tadashi Yamamoto. Human kidney glomerulus proteome and biomarker discovery of kidney diseases. PROTEOMICS CLINICAL APPLICATIONS. 2008. 2. 3. 420-427

Lectures and oral presentations (16)：

抗ネフリン抗体検出簡便法の確立:免疫組織学的手法との感度比較
(第67回日本腎臓学会学術総会 2024)
TRPM4の発現、機能低下とその結果生じるTRPC6機能亢進、Ca2+流入の増加はポドサイト傷害の重要な初期変化である
(第67回日本腎臓学会学術総会 2024)
14-3-3 Proteins Stabilize Vimentin and Actin Filaments to Maintain Primary and Foot Processes in Podocyte
(ASN Kidney Week 2023)
Downregulation of TRPM4 and Consequent Increase in TRPC6 Activity Are Critical Initiation Events Leading to Podocyte Injury
(ASN Kidney Week 2023)
Nephrin-Ephrin-B1-Par6 com6plex is crucial for slit diaphragm in podocytes: Ephrin-B1 suppresses tight junction formation by interfering with Par6-Cdc42 binding
(2022)

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Education (2)：

2003 - 2007 Niigata University Graduate School, Division of Medical Sciences
- 2002 Harbin Medical University, China Faculty of Medicine

Professional career (1)：

医学博士 (新潟大学)

Work history (2)：

2016/04/01 - 現在 Niigata University Graduate School of Medical and Dental Sciences Center of Nephrology Assistant Professor
2015/09/01 - 2016/03/31 Niigata University Graduate School of Medical and Dental Sciences Institute of Nephrology Assistant Professor

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