Research theme for competitive and other funds (4)：
2022 - 2025 New strategic approach for ameliorate hypoxic injury using the PHD1 specific inhibitor and definition of the molecular mechanism.
2022 - 2025 リン資源循環の鍵となるリン酸とアルコールによるリン酸エステル合成反応の開発
2019 - 2022 Selective HIF activation by allosteric PHD inhibition: a novel therapeutic compound for chronic kidney disease
2014 - 2017 Activation of HIF by inhibiting FIH: the development of novel organic molecules inhibiting FIH selectively
Papers (56)：
Kohsuke Fujiwara, Shin-ichi Kawaguchi, Yuki Yamamoto, Yuhei Gonda, Akiya Ogawa. Acyl Iodide Synthesis from Carboxylic Acids Using a Novel Ph2P(O)H-I2 Binary System and Its Application to Facile Preparation of Amides, Esters, and Thioesters. ChemistrySelect. 2024. 9. 39
Sudarma Bogahawaththa, Tomoaki Kawamura, Udari Bandaranayake, Tomoaki Hirakawa, Goki Yamada, Hana Ishino, Tsuzumi Hirohashi, Shin Ichi Kawaguchi, Kavindra K. Wijesundera, Missaka P.B. Wijayagunawardane, et al. Identification and mechanistic investigation of ellagitannins from Osbeckia octandra that attenuate liver fibrosis via the TGF-β/SMAD signaling pathway. Bioscience, Biotechnology and Biochemistry. 2023. 87. 11. 1295-1309
Kento Sonoda, Sudarma Bogahawaththa, Akito Katayama, Saki Ujike, Sae Kuroki, Naho Kitagawa, Kohichi Hirotsuru, Norio Suzuki, Toshio Miyata, Shin-Ichi Kawaguchi, et al. Correction to "Prolyl Hydroxylase Domain Protein Inhibitor Not Harboring a 2-Oxoglutarate Scaffold Protects against Hypoxic Stress". ACS pharmacology & translational science. 2022. 5. 7. 512-512
Kento Sonoda, Sudarma Bogahawatta, Akito Katayama, Saki Ujike, Sae Kuroki, Naho Kitagawa, Kohichi Hirotsuru, Norio Suzuki, Toshio Miyata, Shin-Ichi Kawaguchi, et al. Prolyl Hydroxylase Domain Protein Inhibitor Not Harboring a 2-Oxoglutarate Scaffold Protects against Hypoxic Stress. ACS pharmacology & translational science. 2022. 5. 5. 362-372
Yoshimasa Makita, Shin Ichi Kawaguchi, Shin Ichi Fujiwara. CHARACTERIZATION AND ANTITUMOR ACTIVITY OF FURAZANO[3,4-g]PTERIDINE-2,4(1H,3H)-DIONE. Heterocycles. 2022. 104. 5
