Research theme for competitive and other funds (20)：
2024 - 2027 Development of control method for inflammaging by targeting advanced glycation end products
2024 - 2027 Role of TNF-alpha in knee osteoarthritis pain and analgesic effect of plasma protein HRG
2023 - 2026 運動介入による再生、修復促進効果の新しい機序の解析研究
2021 - 2024 Homeostatic effect of improvement candidate drug targeting IL-33
2020 - 2023 敗血症関連DAMPs拮抗因子HRGの血管保護作用機序の解明
2019 - 2022 Roles of histidine-rich glycoprotein in prevention of hypertensive disorders of pregnancy and in physiological placental development.
2019 - 2022 Analysis dynamics of HMGB1 as a biosensor molecule and its multiple functions
2019 - 2020 血液・血球-血管内皮細胞インターフェイスの恒常性維持機構と網羅的新規創薬
2017 - 2020 敗血症治療のためのHRG血液製剤の創出
2017 - 2020 Elucidation of an inhibitory mechanism of septic immunothrombosis by novel plasma factor:HRG
2016 - 2019 Functional characterization of histidine-rich glycoprotein (HRG) under the inflammatory conditions.
2015 - 2018 Mechanism for microthrombus formation on NETosis and development of therapy for ARDS.
2016 - 2018 Functional analysis of HMGB1 as an inflammatory mediator in periodontitis
2017 - 2018 新規敗血症重症度判定マーカーと治療薬の創出
2013 - 2016 A novel pathological mechanism of Alzheimer's disease as a chronic inflammation through RAGE signal activity.
2012 - 2015 Drug development for brain and spinal cord trauma targeting HMGB1
2011 - 2013 The development of broad-spectrum antitumor agents with anti-HMGB1 antibody and clarification of its action mechanism
2011 - 2012 Development oftherapy for acute traumatic brain injury
2009 - 2011 Mechanism for HMGB-or HMGB1-derived peptide-induced increase in BBB permeability
2009 - 2011 Development of monoclonal antibodies therapy for cerebral infarction and cerebral edema
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Papers (90)：
Masahiro Nishibori, Hidenori Wake, Masakiyo Sakaguchi. The plasma protein HRG is an important factor for preventing sepsis and maintaining homeostatic response. Folia Pharmacologica Japonica. 2024. 159. 2. 107-111
Simeng Ma, Yoki Nakamura, Takahiro Kochi, Suzuna Uemoto, Kazue Hisaoka-Nakashima, Dengli Wang, Keyue Liu, Hidenori Wake, Masahiro Nishibori, Norimitsu Morioka. Perineural Treatment with High Mobility Group Box-1 Monoclonal Antibody Prevents Initiation of Pain-Like Behaviors in Female Mice with Trigeminal Neuropathy. Biological and Pharmaceutical Bulletin. 2024. 47. 1. 221-226
Masahiro Watanabe, Takao Toyomura, Hidenori Wake, Takashi Nishinaka, Omer Faruk Hatipoglu, Hideo Takahashi, Masahiro Nishibori, Shuji Mori. Cationic ribosomal proteins can inhibit pro-inflammatory action stimulated by LPS+HMGB1 and are hindered by advanced glycation end products. Biotechnology and Applied Biochemistry. 2023. 71. 2. 264-271
Takashi Nishinaka, Omer Faruk Hatipoglu, Hidenori Wake, Masahiro Watanabe, Takao Toyomura, Shuji Mori, Masahiro Nishibori, Hideo Takahashi. Different modulation of STING/TBK1/IRF3 signaling by advanced glycation end products. Archives of biochemistry and biophysics. 2023. 750. 109808-109808
Shiho Kitaoka, Ayaka Tomohiro, Shinya Ukeshima, Keyue Liu, Hidenori Wake, Shinya H. Kimura, Yasuhiko Yamamoto, Masahiro Nishibori, Tomoyuki Furuyashiki. Repeated Social Defeat Stress Induces HMGB1 Nuclear Export in Prefrontal Neurons, Leading to Social Avoidance in Mice. Cells. 2023. 12. 13. 1789-1789
