TOMOMASA YOKOMIZO

Affiliation and department：

Research field (2)： Developmental biology , Hematology and oncology

Research theme for competitive and other funds (8)：

2023 - 2026 The physiological and evolutionary significance of the limited site and timing of hematopoietic stem cell development
2023 - 2025 Development of methods for inducing hematopoietic stem cells
2022 - 2025 Elucidation of the molecular basis for age-dependent leukemogenesis towards a novel therapeutic strategy
2020 - 2023 細胞系譜追跡を用いた造血システム発生様式の解析
2017 - 2020 Elucidating the mechanism of hematopoietic stem cell development and maturation by using a novel reporter mouse

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Papers (45)：

Wenjuan Ma, Yuichiro Arima, Terumasa Umemoto, Tomomasa Yokomizo, Yuqing Xu, Kenichi Miharada, Yosuke Tanaka, Toshio Suda. Metabolic regulation in erythroid differentiation by systemic ketogenesis in fasted mice. Experimental hematology. 2023
Mohamed Gaber Abdallah, Vania Swee Imm Teoh, Bibek Dutta, Tomomasa Yokomizo, Motomi Osato. Childhood hematopoietic stem cells constitute the permissive window for RUNX1-ETO leukemogenesis. International journal of hematology. 2023
Yuji Takihara, Takumi Higaki, Tomomasa Yokomizo, Terumasa Umemoto, Kazunori Ariyoshi, Michihiro Hashimoto, Maiko Sezaki, Hitoshi Takizawa, Toshihiro Inoue, Toshio Suda, et al. Bone marrow imaging reveals the migration dynamics of neonatal hematopoietic stem cells. Communications Biology. 2022. 5. 1
Cai Ping Koh, Avinash Govind Bahirvani, Chelsia Qiuxia Wang, Tomomasa Yokomizo, Cherry Ee Lin Ng, Linsen Du, Vinay Tergaonkar, Dominic Chih-Cheng Voon, Hiroaki Kitamura, Hiroki Hosoi, et al. Highly efficient Runx1 enhancer eR1-mediated genetic engineering for fetal, child and adult hematopoietic stem cells. Gene. 2022. 147049-147049
Yuta Koui, Takako Ideue, Michael Boylan, Matthew J Anderson, Motomi Osato, Toshio Suda, Tomomasa Yokomizo, Yoh-Suke Mukouyama. Hepatic leukemia factor-expressing paraxial mesoderm cells contribute to the developing brain vasculature. Biology open. 2022. 11. 9

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MISC (24)：

横溝智雅, 森誠一, 黒川峰夫, 大里元美, 小松則夫. Hlfの発現は造血幹細胞の発生経路特異的に観察される(Hlf expression marks the developmental pathway for hematopoietic stem cells but not for erythroid-myeloid progenitors). 日本癌学会総会記事. 2018. 77回. 1849-1849
大里元美, Ong Kelly Ooi Kee, Mok Michelle Meng Huang, 横溝智雅, 松村貴由, 須田年生, 麻生範雄, Koeffler Phillip, Tenen Daniel G., 清水律子, et al. 急性巨核芽球性白血病に対するNOTCH活性化剤による新規治療(Notch activation impedes cell proliferation and survival in acute megakaryoblastic leukemia). 臨床血液. 2018. 59. 9. 1700-1700
横溝智雅, 渡邊直紀, 梅本晃正, 高久智生, 須田年生, 黒川峰夫, 小松則夫, 大里元美. マウス胎生期における造血幹細胞の成熟はEvi-1/Hlf軸によって制御される(Evi-1/Hlf axis regulates HSC maturation in the mouse embryo). 臨床血液. 2018. 59. 9. 1571-1571
Cai Ping Koh, Cherry Ee Lin Ng, Giselle Sek Suan Nah, Chelsia Qiuxia Wang, Vinay Tergaonkar, Takayoshi Matsumura, Tomomasa Yokomizo, Toshio Suda, Motomi Osato. Hematopoietic stem cell enhancer: A powerful tool in stem cell biology. Histology and Histopathology. 2015. 30. 6. 661-672
飯塚和秀, 横溝智雅, 安田肇, 小林洋平, 高久智生, 小松則夫. マウス胎仔脳血管における造血幹細胞発生の可能性について. 順天堂醫事雑誌. 2013. 59. 6. 526-527

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Education (3)：

Professional career (1)：

Work history (1)：

2022/04 - 現在 Tokyo Women's Medical University Department of Microscopic and Developmental Anatomy

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