Research field (2)：
Environmental effects of chemicals
, Environmental impact assessment
Research keywords (3)：
細胞内受容体
, シトクロムP450
, 化学物質
Research theme for competitive and other funds (10)：
2023 - 2027 小型魚類胚動物代替生体毒性評価法によるAOPの構築と活用
2023 - 2026 有機ハロゲン化合物の汽水産無脊椎動物に対する毒性リスク評価
2020 - 2025 Elucidation of environmental contamination status and bioaccumulation features of emerging perfluoroalkyl substances (PFASs) and assessment of their ecotoxicological effects
2021 - 2024 海産甲殻類を用いたフッ素系殺虫剤の汚染実態解明と環境リスク評価
2019 - 2022 Ecotoxicological assessment of a naturally occurring dioxin, 1,3,7-Tribromodibenzo-p-dioxin in marine invertebrates
2018 - 2020 Study on AOP analysis for ecotoxicogy
2017 - 2020 Scrutiny of developmental impact assessment endpoints with fish embryos
2015 - 2018 Effects of a naturally occurring dioxin, 1,3,7-Tribromodibenzo-p-dioxin on the mysid transcriptome
2009 - 2014 Clarification of factors governing sensitivity of disruption of intracellular receptor-xenobiotic metabolizing enzyme signaling pathways by chemical substances
2012 - 2013 甲殻類エクジソン受容体の分子基盤解明と化学物質の生態リスク評価
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Papers (47)：
Kazuhiro Maeda, Masashi Hirano, Taka Hayashi, Midori Iida, Hiroyuki Kurata, Hiroshi Ishibashi. Elucidating Key Characteristics of PFAS Binding to Human Peroxisome Proliferator-Activated Receptor Alpha: An Explainable Machine Learning Approach. Environmental Science & Technology. 2023
Hoa Thanh Nguyen, Yuka Yoshinouchi, Masashi Hirano, Kei Nomiyama, Haruhiko Nakata, Eun-Young Kim, Hisato Iwata. In silico simulations and molecular descriptors to predict in vitro transactivation potencies of Baikal seal estrogen receptors by environmental contaminants. Ecotoxicology and Environmental Safety. 2023. 265. 115495-115495
Akira Kubota, Masashi Hirano, Yuka Yoshinouchi, Xing Chen, Michiko Nakamura, Yumi Wakayama, Jae Seung Lee, Haruhiko Nakata, Hisato Iwata, Yusuke K. Kawai. In vivo and in silico assessments of estrogenic potencies of bisphenol A and its analogs in zebrafish (Danio rerio): Validity of in silico approaches to predict in vivo effects. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology. 2023. 269. 109619-109619
Masaya Uchida, Hazuki Mizukawa, Masashi Hirano, Nobuaki Tominaga, Koji Arizono, Hiroshi Ishibashi. Adverse effects of contamination by fipronil and its derivatives on growth, molting, and gene expression in the mysid crustacean, Americamysis bahia, in Japanese estuaries. The Science of the total environment. 2023. 164595-164595
Xing Chen, Masashi Hirano, Hiroshi Ishibashi, Jae Seung Lee, Yusuke K. Kawai, Akira Kubota. Efficient in vivo and in silico assessments of antiandrogenic potential in zebrafish. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology. 2023. 264. 109513-109513
平川周作, 堀就英, 香月進, 宮脇崇, 平野将司, 岩田久人, 辻学. Characteristics of dioxins accumulated in Yusho patients and estimation of cytochrome P450-dependent metabolism by in silico docking simulation. 環境化学討論会要旨集(CD-ROM). 2022. 30th
2022/04 - 現在 Tokai University School of Agriculture
2021/04 - 現在 Tokai University School of Agriculture Department of Bioscience
2018/04 - 2021/03 Kumamoto National College of Technology Department of Biological and Chemical Systems Engineering
2016/04 - 2018/03 Kumamoto National College of Technology Department of Biological and Chemical Systems Engineering
2015/04 - 2016/03 Ehime University Center for Marine Environmental Studies
2012/04 - 2015/03 日本学術振興会特別研究員PD
2009/04 - 2012/03 Ehime University Center for Marine Environmental Studies
2007/04 - 2009/03 日本学術振興会特別研究員(DC2)
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Awards (2)：
2012/07 - Pfizer Highly Cited Paper Award Acute toxicity of pharmaceutical and personal care products on freshwater crustacean (Thamnocephalus platyurus) and fish (Oryzias latipes)
