Rchr
J-GLOBAL ID：201601007518534953   Update date: Oct. 15, 2024

Sumihiro Maeda

マエダ スミヒロ | Sumihiro Maeda
Affiliation and department：
Keio University School of Medicine Department of Physiology

About Keio University School of Medicine Department of Physiology


Job title： Senior Assistant Professor (Non-tenured)/Assistant Professor (Non-tenured)
Research field  (4)： Pathobiochemistry ,  Molecular biology ,  Neuroanatomy and physiology ,  Neuroscience - general
Research keywords  (5)： Mouse models ,  Tau protein ,  Alzheimer's disease ,  Epilepsy ,  iPS cells
Research theme for competitive and other funds  (6)：
  • 2021 - 2026 Research on the mechanism of Alzheimer's disease by the analysis of the single-molecule dynamics
  • 2023 - 2025 Study of the starting point and diversity of Tauopathy by single-molecule measurement
  • 2021 - 2025 尿由来細胞を用いた神経疾患モデル細胞の作成
  • 2017 - 2019 ヒトiPS、線維芽細胞から直接誘導された神経細細胞におけるタウタンパク質の解析
  • 2007 - 2009 神経原線維変化形成機構
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Papers (26)：
  • Sopak Supakul, Nicolas Leventoux, Hajime Tabuchi, Masaru Mimura, Daisuke Ito, Sumihiro Maeda, Hideyuki Okano. Establishment of KEIOi005-A iPSC line from urine-derived cells (UDCs) of a mild Alzheimer's disease (AD) donor with multiple risk SNPs for sporadic Alzheimer's disease (sAD). Stem cell research. 2022. 62. 102802-102802
  • Ying Chen, Kunie Sakurai, Sumihiro Maeda, Tohru Masui, Hideyuki Okano, Johannes Dewender, Stefanie Seltmann, Andreas Kurtz, Hiroshi Masuya, Yukio Nakamura, et al. Integrated Collection of Stem Cell Bank Data, a Data Portal for Standardized Stem Cell Information. Stem cell reports. 2021. 16. 4. 997-1005
  • Sopak Supakul, Hideyuki Okano, Sumihiro Maeda. Utilization of Human Induced Pluripotent Stem Cells-Derived In vitro Models for the Future Study of Sex Differences in Alzheimer's Disease. Frontiers in aging neuroscience. 2021. 13. 768948-768948
  • Mari Nakamura, Seiji Shiozawa, Daisuke Tsuboi, Mutsuki Amano, Hirotaka Watanabe, Sumihiro Maeda, Taeko Kimura, Sho Yoshimatsu, Fumihiko Kisa, Celeste M Karch, et al. Pathological Progression Induced by the Frontotemporal Dementia-Associated R406W Tau Mutation in Patient-Derived iPSCs. Stem cell reports. 2019. 13. 4. 684-699
  • Soeda Yoshiyuki, Saito Marino, Maeda Sumihiro, Ishida Kohki, Nakamura Akira, Kojima Shuichi, Takashima Akihiko. Methylene blue inhibits formation of tau fibrils but not of granular tau oligomers. Journal of Alzheimer's Disease. 2019. 68. 4. 1677-1686
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MISC (9)：
  • YOSHIIKE YUJI, YAMASHITA SHUNJI, MIZOROGI TATSUYA, MAEDA SUMIHIRO, MURAYAMA MIYUKI, KIMURA TETSUYA, SAHARA NARUHIKO, SOEDA YOSHIYUKI, ROLOVA TAISIA, TAKASHIMA AKIHIKO. アロキサン投与によるタウTGマウスの不溶性タウおよびHDAC減少を介した微小管安定化と記憶改善. Dement Jpn. 2010. 24. 3. 181
  • YOSHIIKE YUJI, YAMASHITA SHUNJI, MIZOROGI TATSUYA, MAEDA SUMIHIRO, SAITO AKIKO, OSADA HIROYUKI, MURAYAMA MIYUKI, KIMURA TETSUYA, SAHARA NARUHIKO, SOEDA YOSHIYUKI, et al. アロキサン投与によるタウTGマウスにおける不溶性タウの減少と記憶能力改善. Dement Jpn. 2009. 23. 2. 173
  • N. Sahara, S. Maeda, A. Takashima. Tau Oligomerization: A Role for Tau Aggregation Intermediates Linked to Neurodegeneration. CURRENT ALZHEIMER RESEARCH. 2008. 5. 6. 591-598
  • HMAEDA Sumihiro, HR. 神経原線維変化形成機構. Dementia Japan. 2006. 20. 3. 262-270
  • MAEDA SUMIHIRO, SAHARA NARUHIKO, TAKASHIMA AKIHIKO. タウ線維中間体. Dement Jpn. 2006. 20. 3. 262-270
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Lectures and oral presentations  (17)：
  • Epileptic activity caused by soluble tau species
    (タウ研究会2017 2017)
  • Aggregation-dependent and -independent pathogenesis of tau protein
    (Summer school for 2017 2017)
  • Analysis of network dysfunction in hTau-A152T transgenic mice identifies potential new biomarker and opportunity for therapeutic intervention
    (Society for Neuroscience annual meeting 2016)
  • Behavioral, Synaptic, and Neuropathological Changes Caused by A152T Human Tau without Mature Tau Aggregates
    (2015)
  • Behavioral, Synaptic, and Neuropathological Changes Caused by Neuronal Expression of A152T Human Tau in Mice Lacking Mature Tau Aggregates
    (日本認知症学会 学術集会 2015)
ｍore...
Education (4)：
  • 2003 - 2006 Tokyo Institute of Technology Department of Life Science and Technology 分子生命科学専攻
  • 2003 - 2006 Tokyo Institute of Technology Department of Life Science and Technology 分子生命科学専攻
  • 2001 - 2003 Tokyo Institute of Technology Department of Life Science and Technology 分子生命科学専攻
  • 2001 - 2003 Tokyo Institute of Technology Department of Life Science and Technology 分子生命科学専攻
Professional career (1)：
  • Ph. D. (東京工業大学)
Work history (6)：
  • 2018/10 - 現在 Keio University School of Medicine Department of Physiology Assistant Professor
  • 2016/12 - 2018/09 Keio University School of Medicine, Physiology Department Instructor
  • 2015/01 - 2016/11 The J. David Gladstone Institutes Gladstone Institute of Neurological Disease Research scientist
  • 2008/09 - 2014/12 The J. David Gladstone Institutes Gladstone Institute of Neurological Disease Post-doctoral fellow
  • 2006/04 - 2008/08 RIKEN Brain Science Institute, Laboratory for Alzheimer's Disease Post-doctoral fellow
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Awards (5)：
  • 2014 - The J. David Gladstone Institute Career advancement award
  • 2013 - The J. David Gladstone Institute Poster presentation award (1st)
  • 2012 - The J. David Gladstone Institute Poster presentation award (3rd)
  • 2012 - The J. David Gladstone Institute Scientific leadership award
  • 2006 - Neuroscience Research Excellent paper award
Association Membership(s) (3)：
日本神経科学会 ,  Society for Neuroscience ,  日本認知症学会
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