Yohei Hayashi

ハヤシヨウヘイ | Yohei Hayashi

Affiliation and department：
Job title： Team Leader (Principal Investigator)
Homepage URL (2)： https://acd.brc.riken.jp/ja/ , http://www.riken.jp/research/labs/brc/ips_cell_adv_char_dev/

Research field (2)： Medical biochemistry , Cell biology

Research keywords (7)： induced pluripotent stem cells , Embryonic Stem cells , Cellular Reprogramming , Differentiation , Disease Modeling , Reprogramming , iPS Cells

Research theme for competitive and other funds (22)：

2023 - 2026 Cell fate decision by dose of transcription factors
2021 - 2025 Phenotypic screening of genome-edited Induced pluripotent stem cells
2021 - 2024 22q11.2症候群特異的iPS細胞由来神経堤の病態モデルでのゲノム編集応用
2020 - 2023 胆道閉鎖症特異的iPS細胞を用いた胆管発生およびその障害メカニズムの解明
2019 - 2022 Molecular dynamics of epigenomic transcriptional regulation by Klf4 in iPSC generation

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Papers (65)：

Rui Li, Hazuki Tsuboi, Hidenori Ito, Daigo Takagi, Yun-Hsuan Chang, Tomoya Shimizu, Yutaka Arai, Mami Matsuo-Takasaki, Michiya Noguchi, Yukio Nakamura, et al. Generation of human induced pluripotent stem cell lines derived from two glucose transporter 1 deficiency syndrome patients. Stem Cell Research. 2024. 81. 103584-103584
Mami Matsuo-Takasaki, Sho Kambayashi, Yasuko Hemmi, Tamami Wakabayashi, Tomoya Shimizu, Yuri An, Hidenori Ito, Kazuhiro Takeuchi, Masato Ibuki, Terasu Kawashima, et al. Complete suspension culture of human induced pluripotent stem cells supplemented with suppressors of spontaneous differentiation. 2024
Daigo Takagi, Satomi Tsukamoto, Koji Nakade, Tomoya Shimizu, Yutaka Arai, Mami Matsuo-Takasaki, Michiya Noguchi, Yukio Nakamura, Norihiro Yumoto, Jiro Kawada, et al. Generation of MBP-tdTomato reporter human induced pluripotent stem cell line for live myelin visualization. Stem cell research. 2024. 79. 103493-103493
Yutaka Arai, Hidenori Ito, Tomoya Shimizu, Yuzuno Shimoda, Dan Song, Mami Matsuo-Takasaki, Tadayoshi Hayata, Yohei Hayashi. Patient-derived and gene-edited pluripotent stem cells lacking NPHP1 recapitulate juvenile nephronophthisis in abnormalities of primary cilia and renal cyst formation. Frontiers in Cell and Developmental Biology. 2024. 12
Miyu Mori, Shoko Yoshii, Michiya Noguchi, Daigo Takagi, Tomoya Shimizu, Hidenori Ito, Mami Matsuo-Takasaki, Yukio Nakamura, Satoru Takahashi, Hiromichi Hamada, et al. Generation of human induced pluripotent stem cell lines derived from four Rett syndrome patients with MECP2 mutations. Stem Cell Research. 2024. 77. 103432-103432

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MISC (4)：

Y. Hayashi, E. C. Hsiao, S. Sami, M. Lancero, C. R. Schlieve, T. Nguyen, K. Yano, A. Nagahashi, M. Ikeya, Y. Matsumoto, et al. BMP-SMAD-ID signaling axis supports reprogramming to pluripotency. MOLECULAR BIOLOGY OF THE CELL. 2012. 23
Hayashi Y, Hsiao E, Sami S, Lancero M, Schlieve C, Yano K, Nagahashi A, Ikeya M, Matsumoto Y, Asaka I, et al. BMP-SMAD-ID axis promotes reprogramming to pluripotency. 第10 回ISSCR(2012.6.14.横浜). 2012
浅島誠, 林洋平, 古江美保[楠田], 岡林浩嗣, 印東厚, 栗崎晃. 再生医療・組織工学(幹細胞、細胞分化誘導等) マウスES細胞などの幹細胞の分化制御. 日本バイオマテリアル学会大会予稿集. 2008. シンポジウム2008. 60-60
Y. Hayashi, M. Furue, K. Ohnuma, M. Asashima. Laminin promotes differentiation of mouse embryonic stem cells in serum-free adherent monoculture. MECHANISMS OF DEVELOPMENT. 2005. 122. S129-S130

Books (5)：

動物実験代替法とNew approach methodologiesの開発・利用動向
シーエムシー出版 2023 ISBN:9784781317472
細胞培養・組織培養の技術
朝倉書店 2023 ISBN:9784254310962
細胞培養実習テキスト第2版
じほう 2020 ISBN:9784840752923
~医薬品・再生医療製品開発者・技術者のための~iPS細胞の最新技術開発
技術情報協会 2016
細胞培養・品質管理の基礎知識と細胞培養基材の利用・開発・評価の留意点
情報機構 2016

Lectures and oral presentations (6)：

iPS細胞における環状染色体の自己修復
(第16回日本再生医療学会総会 2017)
Structure-based Discovery of NANOG Variant with Enhanced Properties to Promote Self-Renewal and Reprogramming of Pluripotent Stem Cells
(第39回日本分子生物学会大会 2016)
光応答性材料を介した光照射によるiPS細胞の分化操作
(第8回TIAシンポジウム 2016)
Cell-Autonomous Correction of Ring Chromosomes in Human Induced Pluripotent Stem Cells
(TERMIS (Tissue Engineering and Regenerative Medicine International Society) -AP (Asia & Pacific) 2016 2016)
転写因子の構造解析から多能性幹細胞・リプログラミング機構の解明へ
(生命の機能とかたち筑波大学&高エネルギー加速器研究機構第1回連携セミナー 2016)

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Education (3)：

2004 - 2009 The University of Tokyo Graduate School of Arts and Sciences Multi-Disciplinary Sciences Life Sciences
2000 - 2004 The University of Tokyo, College of Arts and Sciences
1997 - 2000 Okazaki High School

Professional career (1)：

Ph. D. (University of Tokyo)

Work history (7)：

2022/07 - 現在 University of Tsukuba School of Integrative and Global Majors Professor
2018/04 - 現在 RIKEN Bioresource Research Center Team Leader
2016/04 - 2018/03 University of Tsukuba Graduate School of Comprehensive Human Sciences Assistant Professor
2015/01 - 2015/03 Research Scientist at Gladstone Institute of Cardiovascular Disease
2014/07 - 2015/03 Postdoctoral Fellow Overseas, Japanese Society for Promoting Sciences

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Committee career (7)：

2023/04 - 現在バイオインダストリー協会バイオエンジニアリング研究会委員
2023/04 - 現在日本再生医療学会産業推進委員会委員
2018/11 - 現在日本再生医療学会代議員
2021/06 - 日本再生医療学会チームU45 メンバー
2021/04 - 日本組織培養学会理事

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Awards (10)：

2019/11 - The Science and technology Promotion Foundation of Ibaraki Tsukuba Encouragement Prize Young Researchers
2018/04 - 筑波大学筑波大学若手教員特別奨励賞
2018/04 - 文部科学省平成30年度科学技術分野の文部科学大臣表彰若手科学者賞
2017/12 - 筑波大学若手教員奨励賞
2014/01 - 7th Takeda Science Foundation Symposium on PharmaScience Excellent Poster Award, 7th Takeda Science Foundation Symposium on PharmaScience

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Association Membership(s) (6)：

バイオインダストリー協会 , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , THE JAPANESE TISSUE CULTURE ASSOCIATION , THE JAPANESE SOCIETY FOR REGENERATIVE MEDICINE , International Society for Stem Cell Research (ISSCR) , Tissue Engineering and Regenerative Medicine International Society (TERMIS)

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