2018 - 2021 Investigation of roles of the synovial macrophage-derived exosomes on the progression of osteoarthritis and rheumatoid arthritis
2017 - 2020 変形性関節症制圧を目指した新規免疫ネットワーク解析手法を用いた治療薬の開発
2017 - 2020 複合細胞移植による新規末梢神経再生方法の開発
2017 - 2019 人工股関節置換術後の骨溶解を制御する新規治療法の開発
2018 - 2019 炎症性骨溶解を制御する新規治療法の開発
2015 - 2017 Elucidation of mechanisms by which host immune cells kill protozoan parasites and development of antiparasitic peptide
Show all
Papers (146)：
Taiki Tokuhiro, Gen Matsumae, Tsutomu Endo, Yuki Ogawa, Takuya Ogawa, Chen Liyile, Yoshio Nishida, Hend Alhasan, Hideyuki Kobayashi, Taku Ebata, et al. Cellular communication network factor 3 contributes to the pathological process of rheumatoid arthritis through promoting cell senescence and osteoclastogenesis in the joint. Journal of Autoimmunity. 2024
Yoshio Nishida, M Alaa Terkawi, Gen Matsumae, Shunichi Yokota, Taiki Tokuhiro, Yuki Ogawa, Hotaka Ishizu, Junki Shiota, Tsutomu Endo, Hend Alhasan, et al. Dynamic transcriptome analysis of osteal macrophages identifies distinct subset with senescence features in experimental osteoporosis. JCI insight. 2024
Takuya Konno, Tomohiro Shimizu, Masahiro Inoue, Takeshi Masuda, Mohamad Alaa Terkawi, Norimasa Iwasaki, Daisuke Takahashi. Midterm Results of Severe Hip Dysplasia after Using a Cementless Acetabular Component with Bulk Bone Graft in Total Hip Arthroplasty: A Minimum Five-Year Follow-Up Study. Bioengineering (Basel, Switzerland). 2024. 11. 8
Tsutomu Endo, Masahiko Takahata, Yoshinao Koike, Ryo Fujita, Daisuke Yoneoka, Masahiro Kanayama, Ken Kadoya, Tomoka Hasegawa, Mohamad Alaa Terkawi, Katsuhisa Yamada, et al. Ossification of the posterior longitudinal ligament is linked to heterotopic ossification of the ankle/foot tendons. Journal of bone and mineral metabolism. 2024
Hideyuki Kobayashi, M Alaa Terkawi, Masahiro Ota, Tomoka Hasegawa, Tomomaya Yamamoto, Tomohiro Shimizu, Dai Sato, Ryo Fujita, Toshifumi Murakami, Norio Amizuka, et al. Involvement of Siglec-15 in regulating RAP1/RAC signaling in cytoskeletal remodeling in osteoclasts mediated by macrophage colony-stimulating factor. Bone research. 2024. 12. 1. 35-35
Drug discovery against Babesia and Toxoplasma. (Apicomplexan Parasites: Molecular Approaches Toward Targeted Drug Development Drug Discovery in Infectious Diseases.
Wiley-VCH, Weinheim 2011
Lectures and oral presentations (2)：
Macrophages: A double-edged sword in aseptic loosening of total joint arthroplasty
(Asia Pacific Society for Biology and Medical Sciences (APSBMS) 2019)
Macrophage and neutrophils, Friend or foe to our health? Journey through our immune system
(帯広畜産大学テニュアトラック研究成果発表会 2016)
Professional career (1)：
PhD (Gifu University, Japan)
Work history (6)：
Department of Orthopedic Surgery, School of Medicine, Hokkaido University, Kita 21, Nishi 11, Kita-ku, Sapporo, Hokkaido 001-0021, Japan Assistant Professor
Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine. Obihiro, Hokkaido, Japan JSPS Postdoctoral Research Fellow
Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine. Obihiro, Hokkaido, Japan Postdoctoral Researcher
The United Graduate School of Veterinary Science. Gifu University, Japan PhD student (MEXT Fellowship from the Japanese Ministry of Education)
Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine. Obihiro, Hokkaido, Japan Researcher
Department of Parasitology. Faculty of Veterinary Medicine, University of Al-Baath. Hama, Syria Teaching Assistant
Show all
Awards (4)：
2019/01 - 北海道整形災害外科学会 学術奨励賞 北海道整形災害外科学会 Society award
2017/03 - 日本学術振興会 Travel Fellowship Award for the Japan-Brazil Malaria Research Workshop Travel Fellowship Award for the Japan-Brazil Malaria Research Workshop
2009/11 - 日本学術振興会外国人特別研究員 JSPS fellowship
Association Membership(s) (5)：
Japan College of Rheumatology
, Japanese society for immunology
, Japanese society for biomaterials
, Japanese society for bone and mineral research
, HOSP
