2018 - 2021 Investigation of roles of the synovial macrophage-derived exosomes on the progression of osteoarthritis and rheumatoid arthritis
2017 - 2020 変形性関節症制圧を目指した新規免疫ネットワーク解析手法を用いた治療薬の開発
2017 - 2020 複合細胞移植による新規末梢神経再生方法の開発
2017 - 2019 人工股関節置換術後の骨溶解を制御する新規治療法の開発
2018 - 2019 炎症性骨溶解を制御する新規治療法の開発
2015 - 2017 Elucidation of mechanisms by which host immune cells kill protozoan parasites and development of antiparasitic peptide
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Papers (130):
Ryo Fujita, Tsutomu Endo, Masahiko Takahata, Yoshinao Koike, Daisuke Yoneoka, Ryota Suzuki, Masaru Tanaka, Katsuhisa Yamada, Hideki Sudo, Tomoka Hasegawa, et al. High whole-body bone mineral density in ossification of the posterior longitudinal ligament. The spine journal : official journal of the North American Spine Society. 2023. 23. 10. 1461-1470
Shotaro Fukada, Tsutomu Endo, Masahiko Takahata, Masahiro Kanayama, Yoshinao Koike, Ryo Fujita, Ryota Suzuki, Toshifumi Murakami, Tomoka Hasegawa, Mohamad Alaa Terkawi, et al. Dyslipidemia as a novel risk for the development of symptomatic ossification of the posterior longitudinal ligament. The spine journal : official journal of the North American Spine Society. 2023. 23. 9. 1287-1295
Taku Ebata, Mohamad Alaa Terkawi, Keita Kitahara, Syunichi Yokota, Junki Shiota, Yoshio Nishida, Gen Matsumae, Hend Alhasan, Masanari Hamasaki, Kazutoshi Hontani, et al. Macrophage-derived extracellular vesicles trigger non-canonical pyroptosis in chondrocytes leading to cartilage catabolism in osteoarthritis. Arthritis & Rheumatology. 2023
Hotaka Ishizu, Tomohiro Shimizu, Fumio Sasazawa, Daisuke Takahashi, Mohamad Alaa Terkawi, Kaname Takahashi, Yusuke Ohashi, Masahiro Kanayama, Norimasa Iwasaki. Comparison of re-revision rate and radiological outcomes between Kerboull-type plate and metal mesh with impaction bone grafting for revision total hip arthroplasty. BMC musculoskeletal disorders. 2023. 24. 1. 134-134
Kazuha Nakabachi, Tsutomu Endo, Masahiko Takahata, Ryo Fujita, Yoshinao Koike, Ryota Suzuki, Yuichi Hasegawa, Toshifumi Murakami, Katsuhisa Yamada, Hideki Sudo, et al. Lumbar ossification of the ligamentum flavum reflects a strong ossification tendency of the entire spinal ligament. Scientific reports. 2023. 13. 1. 638-638
Drug discovery against Babesia and Toxoplasma. (Apicomplexan Parasites: Molecular Approaches Toward Targeted Drug Development Drug Discovery in Infectious Diseases.
Wiley-VCH, Weinheim 2011
Lectures and oral presentations (2):
Macrophages: A double-edged sword in aseptic loosening of total joint arthroplasty
(Asia Pacific Society for Biology and Medical Sciences (APSBMS) 2019)
Macrophage and neutrophils, Friend or foe to our health? Journey through our immune system
(帯広畜産大学テニュアトラック研究成果発表会 2016)
Professional career (1):
PhD (Gifu University, Japan)
Work history (6):
Department of Orthopedic Surgery, School of Medicine, Hokkaido University, Kita 21, Nishi 11, Kita-ku, Sapporo, Hokkaido 001-0021, Japan Assistant Professor
Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine. Obihiro, Hokkaido, Japan JSPS Postdoctoral Research Fellow
Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine. Obihiro, Hokkaido, Japan Postdoctoral Researcher
The United Graduate School of Veterinary Science. Gifu University, Japan PhD student (MEXT Fellowship from the Japanese Ministry of Education)
Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine. Obihiro, Hokkaido, Japan Researcher
Department of Parasitology. Faculty of Veterinary Medicine, University of Al-Baath. Hama, Syria Teaching Assistant
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Awards (4):
2019/01 - 北海道整形災害外科学会 学術奨励賞 北海道整形災害外科学会 Society award
2017/03 - 日本学術振興会 Travel Fellowship Award for the Japan-Brazil Malaria Research Workshop Travel Fellowship Award for the Japan-Brazil Malaria Research Workshop
2009/11 - 日本学術振興会外国人特別研究員 JSPS fellowship
Association Membership(s) (5):
Japan College of Rheumatology
, Japanese society for immunology
, Japanese society for biomaterials
, Japanese society for bone and mineral research
, HOSP