Rchr
J-GLOBAL ID：201601008958277797   Update date: Oct. 03, 2024

Miyata Keishi

Miyata Keishi
Affiliation and department：
Kumamoto University Graduate School of Medical Sciences

About Kumamoto University Graduate School of Medical Sciences


Job title： Visiting Professor
Homepage URL  (1)： http://www.kumamoto-u-molgene.jp
Research field  (3)： Cardiology ,  Molecular biology ,  Genomics
Research keywords  (5)： 心不全 ,  ミトコンドリア ,  アンジオポエチン様因子 ,  長鎖ノンコーディングRNA ,  慢性炎症
Research theme for competitive and other funds  (10)：
  • 2022 - 2025 Elucidation of the pathophysiology of heart failure targeting iron and its novel treatment strategy
  • 2019 - 2022 Elucidation of novel molecular mechanisms of the treatment strategy for heart failure by inactivating the DNA damage response
  • 2017 - 2020 Mechanism of arteriosclerosis targeting chronic inflammation and possibility of new drug treatment
  • 2016 - 2019 The role of microRNA in molecular mechanism of heart failure development
  • 2015 - 2018 The discovery of a new predictor of aortic aneurysm rupture
Show all
Papers (114)：
  • Shinsei Yumoto, Haruki Horiguchi, Tsuyoshi Kadomatsu, Taichi Horino, Michio Sato, Kazutoyo Terada, Keishi Miyata, Toshiro Moroishi, Hideo Baba, Yuichi Oike. Host ANGPTL2 establishes an immunosuppressive tumor microenvironment and resistance to immune checkpoint therapy. Cancer science. 2024
  • Haruki Horiguchi, Tsuyoshi Kadomatsu, Tomoya Yamashita, Shinsei Yumoto, Taichi Horino, Michio Sato, Kazutoyo Terada, Keishi Miyata, Yuki Ichigozaki, Toshihiro Kimura, et al. Tumor stroma-derived ANGPTL2 potentiates immune checkpoint inhibitor efficacy. Cancer gene therapy. 2024
  • Hirotaka Fukami, Jun Morinaga, Hironori Nakagami, Hiroki Hayashi, Yusuke Okadome, Eiji Matsunaga, Tsuyoshi Kadomatsu, Haruki Horiguchi, Michio Sato, Taichi Sugizaki, et al. Efficacy and safety in mice of repeated, lifelong administration of an ANGPTL3 vaccine. npj Vaccines. 2023. 8. 1
  • Nanami Namba, Takehiro Kuwahara, Yuki Kondo, Kumiko Fukusaki, Keishi Miyata, Yuichi Oike, Tetsumi Irie, Yoichi Ishitsuka. Fasudil inhibits the expression of C/EBP homologous protein to protect against liver injury in acetaminophen-overdosed mice. Biochemical and Biophysical Research Communications. 2023. 149166-149166
  • Haruki Horiguchi, Tsuyoshi Kadomatsu, Tomoya Yamashita, Shinsei Yumoto, Kazutoyo Terada, Michio Sato, Jun Morinaga, Keishi Miyata, Yuichi Oike. ANGPTL2 promotes immune checkpoint inhibitor-related murine autoimmune myocarditis. Communications biology. 2023. 6. 1. 965-965
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MISC (53)：
  • Sato Michio, Kadomatsu Tsuyoshi, Miyata Keishi, Node Koichi, Oike Yuichi. lncRNA Caren Human Ortholog Attenuates Heart Failure Progression in Mice(タイトル和訳中). 日本循環器学会学術集会抄録集. 2023. 87回. PE09-2
  • Watanabe Tomoya, Watanabe Yukihiko, Miyata Keishi, Oike Yuichi, Yamaguchi Yukie. Exacerbated psoriasis-like inflammation in K14-angiopoietin-like protein 2 transgenic mice treated with imiquimod(タイトル和訳中). 日本研究皮膚科学会年次学術大会・総会プログラム. 2022. 47回. 190-190
  • Sato Michio, Miyata Keishi, Node Koichi, Oike Yuichi. ミトコンドリア生合成とDNA損傷応答の制御を利用した有効な抗心不全療法の開発(Development of an Effective anti-Heart Failure Therapy through Regulating Mitochondrial Biogenesis and DNA Damage Response). 日本内分泌学会雑誌. 2022. 97. 5. 1478-1478
  • 佐藤迪夫, 宮田敬士, 野出孝一, 尾池雄一. Development of an Effective Therapy for Heart Failure by Regulating DNA Damage Response and Mitochondrial Biogenesis. 日本循環器学会学術集会(Web). 2022. 86th
  • Sato Michio, Miyata Keishi, Kadomatsu Tsuyoshi, Node Koichi, Oike Yuichi. lncRNAであるCarenはATM-DNA損傷応答経路を不活化し、ミトコンドリア生合成を活性化することで心不全を予防する(The lncRNA Caren Protects against Heart Failure by Inactivating the ATM-DNA Damage Response Pathway and Activating Mitochondrial Biogenesis). 日本循環器学会学術集会抄録集. 2021. 85回. YIA-3
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Patents (2)：
Books (2)：
  • 論文図表を読む作法 : はじめて出会う実験&解析法も正しく解釈! : 生命科学・医学論文をスラスラ読むためのFigure事典 第5章 代謝解析 6 代謝ケージによるマウス代謝測定
    羊土社 2022 ISBN:9784758122603
  • 第4章 慢性炎症関連因子 series モデル動物利用マニュアル 疾患モデルの作製と利用 -脂質代謝異常と関連疾患 下巻 Angptl2
    株式会社エル・アイ・シー 2015
Lectures and oral presentations  (7)：
  • Recent Progress on Cardiovascular Gene and Cell Therapy ANGPTL2:a novel therapeutic targeting in heart failure
    (2017)
  • Endurance Exercise-induced miR221/222 Promotes Cardioprotection via ANGPTL2 Suppression.
    (2017)
  • 病的血管リモデリングにおける血管周囲脂肪組織由来Angiopoietin-like protein 2 (Angptl2)の役割
    (第23回日本血管生物医学会学術集会 2015)
  • Angiopoietin-like protein 2 (Angptl2) prevents heart failure in murine left ventricular pressure-overload model
    (第78回日本循環器学会学術集会 2014)
  • Angiopoietin-related growth factor has functions of exercise capacity and cold-induced thermogenesis
    (第35回日本分子生物学会年会 2012)
ｍore...
Education (2)：
  • - 2004 Kumamoto University
  • - 1996 Yamaguchi University School of Medicine
Professional career (1)：
  • 博士(医学) (熊本大学)
Work history (5)：
  • 2021/11 - 現在 Kumamoto University
  • 2021/04 - 2021/10 Kumamoto University
  • 2011/04 - 2021/03 Kumamoto University Department of Immunology, Allergy and Vascular Medicine
  • 2009/04 - 2011/03 Kumamoto University Faculty of Life Sciences
  • 2008/02 - 2009/03 Kumamoto University Faculty of Life Sciences
Committee career (1)：
  • 2018 - 現在 日本血管生物医学会 評議員
Association Membership(s) (5)：
THE JAPANESE SOCIETY OF INTERNAL MEDICINE ,  THE JAPANESE CIRCULATION SOCIETY ,  THE JAPANESE SOCIETY OF INTERNAL MEDICINE ,  日本血管生物医学会 ,  THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
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