Nozawa Akifumi

Affiliation and department：

Research field (1)： Fetal medicine/Pediatrics

Research theme for competitive and other funds (4)：

2022 - 2025 Elucidation of pathogenesis and development of new treatment for refractory vascular malformation syndrome by genetic analysis
2022 - 2025 KRAS遺伝子変異導入モデルを用いたゴーハム病発症機序解明と新規治療薬の探索
2020 - 2022 Analysis of a mouse model of generalized lymphatic anomaly
2017 - 2019 Elucidating pathogenic mechanisms of Gorham-stout disease

Papers (45)：

Akifumi Nozawa, Taiki Abe, Tetsuya Niihori, Michio Ozeki, Yoko Aoki, Hidenori Ohnishi. Lymphatic endothelial cell-specific NRAS p.Q61R mutant embryos show abnormal lymphatic vessel morphogenesis. Human molecular genetics. 2024
Michio Ozeki, Saori Endo, Shiho Yasue, Akifumi Nozawa, Ryuta Asada, Akiko M Saito, Hiroya Hashimoto, Takumi Fujimura, Yohei Yamada, Tatsuo Kuroda, et al. Sirolimus Treatment for Intractable Lymphatic Anomalies: An Open-label, Single-arm, Multicenter, Prospective Trial. Frontiers in Medicine. 2024. 11. 1335469-1335469
Shiho Yasue, Michio Ozeki, Akifumi Nozawa, Saori Endo, Hidenori Ohnishi. Changes in cell morphology and function induced by the NRAS Q61R mutation in lymphatic endothelial cells. PloS one. 2024. 19. 5. e0289187
安江志保, 小関道夫, 林大地, 野澤明史, 遠渡沙緒理, 國枝香南子, 坂口和弥, 加藤博基, 松尾政之, 大西秀典. Klippel-Trenaunay症候群の診断におけるMRIと遺伝子解析の有用性. 日本小児科学会雑誌. 2023. 127. 6. 823-832
Akifumi Nozawa, Akihiro Fujino, Shunsuke Yuzuriha, Souichi Suenobu, Aiko Kato, Fumiaki Shimizu, Noriko Aramaki-Hattori, Kanako Kuniyeda, Kazuya Sakaguchi, Hidenori Ohnishi, et al. Comprehensive targeted next-generation sequencing in patients with slow-flow vascular malformations. Journal of human genetics. 2022. 67. 12. 721-728

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MISC (49)：

青木洋子, 野澤明史, 小関道夫, 阿部太紀, 新堀哲也. RASopathies and lymphatic malformation. リンパ学. 2024. 47. Supplement
青木洋子, 野澤明史, 野澤明史, 阿部太紀, 新堀哲也, 小関道夫. Somatic RASopathies:リンパ管腫症・Gorham病の原因検索. 日本遺伝子診療学会大会プログラム・抄録集. 2022. 29th
Akifumi Nozawa, Yoko Aoki, Taiki Abe, Tetsuya Niihori, Michio Ozeki, Shiho Yasue, Saori Endo, Hidenori Ohnishi. Identification of Somatic Activating Variants of the RAS/MAPK Pathway in Patients with Complex Lymphatic Anomalies. PEDIATRIC BLOOD & CANCER. 2021. 68
野澤明史, 野澤明史, 青木洋子, 阿部太紀, 新堀哲也, 小関道夫, 安江志保, 遠渡沙緒理, 大西秀典. 複雑型脈管異常におけるRAS遺伝子変異の同定. 日本血管腫血管奇形学会学術集会プログラム・抄録集. 2021. 17th
遠渡沙緒理, 井川博敬, 宮崎太地, 野澤明史, 安江志保, 小関道夫, 深尾敏幸, 野口慶, 小林一博, 酒々井夏子, et al. 組織診断に難渋している巨大脳室内腫瘍の一例. 日本小児血液・がん学会雑誌(Web). 2020. 57. 5

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