KISHIMOTO HISANAO

キシモトヒサナオ | KISHIMOTO HISANAO

Affiliation and department：
Job title： Associate Professor / Lecturer
Homepage URL (2)： https://kaken.nii.ac.jp/d/r/80723600.ja.html , https://www.ps.toyaku.ac.jp/yakubutsudotai/

Research field (3)： Clinical pharmacy , Clinical pharmacy , Clinical pharmacy

Research keywords (6)： Unstirred water layer:UWL , Mucin - drug interaction , mucin , Mucus Layer , Drug Absorption , Biopharmaceutics

Research theme for competitive and other funds (9)：

2021 - 2024 消化管の薬物吸収を制御する新規促進拡散型オリゴペプチドトランスポーターの分子同定
2021 - 2024 Absorption mechanism of nucleosides and their analogs in the gastrointestinal tract
2021 - 2024 膜結合型mucinによる薬物吸収制御機構の解明
2018 - 2020 消化管におけるmucin 分子の機能解明に基づく薬物吸収動態の変動要因解析
2017 - 2019 薬物吸収における非攪拌水層構成タンパク質の機能及び分子機構の解明

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Papers (29)：

Hisanao Kishimoto, Caroline Ridley, Katsuhisa Inoue, David J. Thornton. Assessment of polymeric mucin-drug interactions. PLOS ONE. 2024
Koki Sugiyama, Hiroe Shimano, Masaki Takahashi, Yuta Shimura, Asuka Shimura, Takahito Furuya, Ryuto Tomabechi, Yoshiyuki Shirasaka, Kei Higuchi, Hisanao Kishimoto, et al. The Use of Carboxyfluorescein Reveals the Transport Function of MCT6/SLC16A5 Associated with CD147 as a Chloride-Sensitive Organic Anion Transporter in Mammalian Cells. Journal of Pharmaceutical Sciences. 2023
Keisuke Kiyomiya, Ryuto Tomabechi, Naoki Saito, Kenta Watai, Tappei Takada, Yoshiyuki Shirasaka, Hisanao Kishimoto, Kei Higuchi, Katsuhisa Inoue. Macrolide and Ketolide Antibiotics Inhibit the Cytotoxic Effect of Trastuzumab Emtansine in HER2-Positive Breast Cancer Cells: Implication of a Potential Drug-ADC Interaction in Cancer Chemotherapy. Molecular Pharmaceutics. 2023
Kei Higuchi, Misato Kunieda, Koki Sugiyama, Ryuto Tomabechi, Hisanao Kishimoto, Katsuhisa Inoue. Monocarboxylate Transporter 13 (MCT13/SLC16A13) Functions as a Novel Plasma Membrane Oligopeptide Transporter. Nutrients. 2023. 15. 16
Kaori Miyazaki, Hisanao Kishimoto, Hanai Kobayashi, Ayaka Suzuki, Kei Higuchi, Yoshiyuki Shirasaka, Katsuhisa Inoue. The GlycosylatedN-Terminal Domain of MUC1 Is Involved in Chemoresistance by Modulating Drug Permeation Across the Plasma Membrane. Molecular Pharmacology. 2022. 103. 3. 166-175

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MISC (5)：

清宮啓介, 苫米地隆人, 齊藤直希, 渡井健太, 高田龍平, 白坂善之, 岸本久直, 樋口慧, 井上勝央. The Effect of Macrolide Antibiotics on the Cytotoxicity of Trastuzumab Emtansine. 日本薬学会年会要旨集(Web). 2024. 144th
齊藤直希, 苫米地隆人, 川喜多佑香, 清宮啓介, 岸本久直, 樋口慧, 井上勝央. Exploration of genetic polymorphisms in SLC46A3 that affect the efficacy of trastuzumab emtansine. 日本薬学会年会要旨集(Web). 2024. 144th
岸本久直, 井上勝央. 薬物の腸管吸収過程における粘液層の寄与とその分子機構解明を目指して. ファルマシア. 2020. 56. 4. 325-329
苫米地隆人, 志村可奈恵, 飯田奏子, 浜田圭佑, 岸本久直, 岸本久直, 白坂善之, 白坂善之, 田口晃弘, 野水基義, et al. Peptide transporters enhance the readthrough activity of a negamycin derivative TCP-112. 日本薬剤学会年会講演要旨集(CD-ROM). 2020. 35th
Hisanao Kishimoto, Yusuke Takizawa, Mikio Tomita, Masahiro Hayashi. Changes in intestinal mucosal membrane barrier function by ischemia/reperfusion. YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN. 2007. 127. 59-60

Lectures and oral presentations (92)：

リソソームトランスポーターSLC46A3を介したトラスツズマブエムタンシン-薬物相互作用に関する検討
(医療薬学フォーラム2022 2022)
中分子環状ペプチドと高分子ゲル形成ムチン間での相互作用評価
(日本薬剤学会第37年会 2022)
モノカルボン酸トランスポーター6(MCT6)の輸送解析
(2022)
リソソーム膜タンパク質SLC46A3の機能同定
(日本薬剤学会第37年会 2022)
オーファントランスポーターMCT7/Slc16a6の内因性基質の同定
(日本薬剤学会第37年会 2022)

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Education (2)：

Professional career (1)：

Work history (5)：

2023/04 - 現在 Tokyo University of Pharmacy and Life Sciences School of Pharmacy
2016/04 - 2023/03 Tokyo University of Pharmacy and Life Sciences School of Pharmacy
2019/10 - 2020/12 The University of Manchester Wellcome Trust Centre for Cell-Matrix Research Visiting Reserch Fellow
2013/07 - 2016/03 Tokyo University of Pharmacy and Life Sciences School of Pharmacy
2009/04 - 2013/06 大正製薬株式会社医薬事業部門製薬技術研究所研究員

Committee career (5)：

Awards (2)：

2024/06 - Mucins in Health and Disease Best Poster Presentation Award at the 17th Mucins in Health and Disease Conference
2015/11 - 第21回創剤フォーラム若手研究会 Most Impressive Poster Award

Association Membership(s) (3)：

THE PHARMACEUTICAL SOCIETY OF JAPAN , THE ACADEMY OF PHARMACEUTICAL SCIENCE AND TECHNOLOGY, JAPAN , THE JAPANESE SOCIETY FOR THE STUDY OF XENOBIOTICS

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