Rchr
J-GLOBAL ID:201601010069884732   Update date: Sep. 01, 2022

Horigane Shin'ichiro

ホリガネ シンイチロウ | Horigane Shin'ichiro
Affiliation and department:
Job title: Lecturer
Other affiliations (2):
Research field  (2): Neuropathology ,  Neuroscience - general
Research keywords  (6): Neurodevelopmental disorders ,  Voltage dependent Ca2+ channels (VDCCs) ,  Live imagign ,  Neuronal migration ,  Calcium signaling ,  Neuronal circuit formation
Research theme for competitive and other funds  (6):
  • 2022 - 2024 Deciphering inhibitory neural circuit abnormality underlying autism spectrum disorder and investigation of a new therapeutic approach
  • 2022 - 2023 自閉スペクトラム症に合併する運動機能障害に対する新たな治療戦略の開発
  • 2020 - 2022 カルシウムシグナリング破綻に着目した自閉スペクトラム症における神経回路病態の解明
  • 2019 - 2021 新規病態モデルを用いた多角的解析による発達障害の神経回路病態解明
  • 2019 - 2021 自閉スペクトラム症の病態理解にむけたカルシウムシグナリング破綻を原因とする神経回路形成障害の解明
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Papers (14):
  • Hajime Fujii, Hiroyuki Kidokoro, Yayoi Kondo, Masahiro Kawaguchi, Shin-ichiro Horigane, Jun Natsume, Sayaka Takemoto-Kimura, Haruhiko Bito. Förster resonance energy transfer-based kinase mutation phenotyping reveals an aberrant facilitation of Ca2+/calmodulin-dependent CaMKIIα activity in de novo mutations related to intellectual disability. Frontiers in Molecular Neuroscience. 2022
  • Chenyao Wang*, Shin-ichiro Horigane*, Minoru Wakamori*, Shuhei Ueda, Takeshi Kawabata, Hajime Fujii, Itaru Kushima, Hiroki Kimura, Kanako Ishizuka, Yukako Nakamura, et al. Identification of ultra-rare disruptive variants in voltage-gated calcium channel-encoding genes in Japanese samples of schizophrenia and autism spectrum disorder. Translational psychiatry. 2022. 12. 1. 84-84
  • Masayuki Sakamoto, Masatoshi Inoue, Atsuya Takeuchi, Shigetaka Kobari, Tatsushi Yokoyama, Shin-ichiro Horigane, Sayaka Takemoto-Kimura, Manabu Abe, Kenji Sakimura, Masanobu Kano, et al. A Flp-dependent G-CaMP9a transgenic mouse for neuronal imaging in vivo. Cell Reports Methods. 2022. 100168-100168
  • Shin-Ichiro Horigane, Shun Hamada, Satoshi Kamijo, Hirokazu Yamada, Miwako Yamasaki, Masahiko Watanabe, Haruhiko Bito, Toshihisa Ohtsuka, Sayaka Takemoto-Kimura. Development of an L-type Ca2+ channel-dependent Ca2+ transient during the radial migration of cortical excitatory neurons. Neuroscience research. 2021
  • Takanori Matsubara, Takayuki Yanagida, Noriaki Kawaguchi, Takashi Nakano, Junichiro Yoshimoto, Maiko Sezaki, Hitoshi Takizawa, Satoshi P Tsunoda, Shin-Ichiro Horigane, Shuhei Ueda, et al. Remote control of neural function by X-ray-induced scintillation. Nature communications. 2021. 12. 1. 4478-4478
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MISC (2):
  • 堀金慎一郎. 放射状移動中の大脳皮質興奮性神経細胞におけるL型カルシウムチャネル依存的な一過的細胞内カルシウム濃度上昇の発達. 神経科学ニュース. 2022
  • HORIGANE Shin-ichiro, Sayaka Takemoto-Kimura. Intracellular Ca2+ signaling regulates neuronal migration in the developmental period. 2019. 30. 1
Patents (2):
  • Timothy症候群のモデル動物
  • 細胞内カルシウム動態評価系
Lectures and oral presentations  (7):
  • Calcium transients control a morphogenetic cycle underlying neuronal migratory movement
    (2019)
  • Deciphering a calcium-regulated pathway that controls radial migration of cortical neurons via the excitation-coupled morphological change
    (Neuro 2019 2019)
  • Deciphering a calcium-regulated pathway that controls radial migration of im mature cortical neurons
    (The Joint Congress of the 40th Annual Meeting of Japanese Society of Biological Psychiatry and the 61st Annual Meeting of the Japanese Society for Neurochemistry 2018)
  • Deciphering a calcium-regulated pathway that controls radial migration of im mature cortical neurons
    (The 41st Annual Meeting of Japan Neuroscience Society 2018)
  • Deciphering Ca2+ signaling during radial migration of immature cortical neurons.
    (The 60th Annual Meeting of the Japanese Society for Neurochemistry (JSN) 2017)
more...
Professional career (1):
  • 博士(医学) (東京大学)
Work history (5):
  • 2020/10 - 現在 Nagoya University Research Institute of Environmental Medicine Associate professor/lecturer
  • 2016/03 - 2020/09 Nagoya University Research Institute of Environmental Medicine Assistant Professor
  • 2015/09/01 - 2016/02/29 Nagoya University Research Institute of Environmental Medicine
  • 2015/04 - 2015/08 The University of Tokyo Graduate School of Medicine
  • 2012/04 - 2015/03 日本学術振興会特別研究員(DC1)
Association Membership(s) (3):
日本神経科学会 ,  Society for Neuroscience ,  The Japanese Society for Neurochemistry
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