Rchr
J-GLOBAL ID：201601010464046851   Update date: Jul. 23, 2024

Watanabe Naoki

ワタナベ ナオキ | Watanabe Naoki
Affiliation and department：
Shiga University of Medical Science Molecular Neuroscience Research Center

About Shiga University of Medical Science Molecular Neuroscience Research Center


Job title： Assistant Professor
Research field  (2)： Neuroscience - general ,  Neuropathology
Research keywords  (10)： neuroscience ,  神経 ,  cerebrum ,  Brain ,  ニューロン ,  Alzheimer's disease ,  アミロイドβ ,  APP ,  遺伝子ターゲティング ,  ノックアウトマウス
Research theme for competitive and other funds  (7)：
  • 2023 - 2026 新規amyloid-β抑制因子ILEIの減少に伴うアルツハイマー病リスクと分子制御機構の解析
  • 2020 - 2023 新規アミロイドβ産生抑制分子ILEIの発現低下によるアルツハイマー病リスクの検証
  • 2019 - 2023 Development of preventive therapy for Alzheimer's disease by modification in expressional levels of the risk genes
  • 2016 - 2021 新たな作用機序を介する分子を標的としたアルツハイマー病の予防的治療法の実証的研究
  • 2017 - 2020 Can the age-related decrease in the expression of the novel secretory molecule ILEI be the primary factor in Alzheimer's disease?
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Papers (9)：
  • Naoki Watanabe, Masaki Nakano, Yachiyo Mitsuishi, Norikazu Hara, Tatsuo Mano, Atsushi Iwata, Shigeo Murayama, Toshiharu Suzuki, Takeshi Ikeuchi, Masaki Nishimura. Transcriptional downregulation of FAM3C/ILEI in the Alzheimer's brain. Human molecular genetics. 2021. 31. 1. 122-132
  • Masaki Nakano, Yachiyo Mitsuishi, Lei Liu, Naoki Watanabe, Emi Hibino, Saori Hata, Takashi Saito, Takaomi C Saido, Shigeo Murayama, Kensaku Kasuga, et al. Extracellular Release of ILEI/FAM3C and Amyloid-β Is Associated with the Activation of Distinct Synapse Subpopulations. Journal of Alzheimer's disease : JAD. 2021. 80. 1. 159-174
  • Masaki Nishimura, Naoki Watanabe, Emi Hibino, Masaki Nakano, Yachiyo Mitsuishi, Lei Liu, Takuma Sugi. FAM3C in Alzheimer's disease: a risk-related molecule and potential therapeutic target. Genetics, Neurology, Behavior, and Diet in Dementia; The Neuroscience of Dementia. 2020. 2. 19. 293-307
  • Yasunari Seita, Toshifumi Morimura, Naoki Watanabe, Chizuru Iwatani, Hideaki Tsuchiya, Shinichiro Nakamura, Toshiharu Suzuki, Daijiro Yanagisawa, Tomoyuki Tsukiyama, Masataka Nakaya, et al. Generation of Transgenic Cynomolgus Monkeys Overexpressing the Gene for Amyloid-β Precursor Protein. Journal of Alzheimer's disease : JAD. 2020. 75. 1. 45-60
  • Akihiro Kawatsuki, Shin-Ya Morita, Naoki Watanabe, Emi Hibino, Yachiyo Mitsuishi, Takuma Sugi, Shigeo Murayama, Masaki Nishimura. Lipid class composition of membrane and raft fractions from brains of individuals with Alzheimer's disease. Biochemistry and biophysics reports. 2019. 20. 100704-100704
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MISC (19)：
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Lectures and oral presentations  (24)：
  • 原因遺伝子プレセニリンならびに危険因子ApoE研究の新展開 PresenilinによるAβ産生のデュアル制御メカニズム
    (第41回日本認知症学会学術集会 第37回日本老年精神医学会[合同開催] 2022)
  • 新規Aβ産生抑制分子ILEIの発現低下によるアルツハイマー病リスクの検証
    (第41回日本認知症学会学術集会 第37回日本老年精神医学会[合同開催] 2022)
  • Aβ産生抑制分子ILEI/FAM3Cの発現制御機構
    (第40回日本認知症学会学術集会 2021)
  • Aβ産生を抑制するILEI/FAM3Cの転写制御メカニズム解析
    (Dementia Japan 2020)
  • Alzheimer病動物モデルの現状とAPP-Tgカニクイザルのデザイン
    (2019年度 SUMSグランド・ラウンド(第11回) 2020)
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Education (3)：
  • 2011 - 2015 京都大学大学院 医学研究科 医学専攻博士課程
  • 2009 - 2011 京都大学大学院 医学研究科 医科学専攻修士課程
  • 2005 - 2009 Kyushu University School of Sciences Department of Biology
Professional career (1)：
  • 博士(医学) (京都大学大学院医学研究科)
Work history (3)：
  • 2016/04 - 現在 Shiga University of Medical Science Molecular Neuroscience Research Center Assistant Professor
  • 2015/07 - 2016/03 Shiga University of Medical Science Molecular Neuroscience Research Center Assistant Professor
  • 2015/04 - 2015/06 Kyoto University Institute for Virus Research
Association Membership(s) (4)：
JAPAN SOCIETY FOR DEMENTIA RESEARCH ,  Society for Neuroscience ,  THE JAPAN NEUROSCIENCE SOCIETY ,  THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
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