2020 - 2022 Identification of key factors for tooth development using spatial transcriptomics
2019 - 2022 The clarification of bone formation and absorption mechanism in the bone marrow microenvironment
2018 - 2021 Understanding of molecular mechanisms of tooth development using iPS interference and application to tooth regeneration techniques
2018 - 2021 The functional analysis of WISP1 gene aimed at the prevention of osteoarthritis
2017 - 2021 Molecular understanding of the accumulation of mesenchymal stem cells in vivo by photo-manipulation techniques and its application to bone-related diseases
2018 - 2020 Elucidation of undifferentiated maintaining mechanism of stem cell towards the control of stem cell aging
2017 - 2020 Understanding of periodontal disease and peri-implantitis with stem cell disfunction
2017 - 2020 Application of artificial periosteum containing BMP-2 to the treatment of refractory bone disease and bone nonunion.
2016 - 2019 The development of bone regeneration therapy based on the clarification of mechanism of BMP-2 induced bone formation and resorption
2016 - 2019 A comprehensive search applying 16SrRNA sequencing analysis to investigate oral and intestinal flora causing malnutrition in the elderly
2016 - 2019 Bone regenerative therapy using Escherichia coli-derived rhBMP-2 adsorbed in beta-TCP.
2015 - 2019 Guided control of keratinized epithelial mucosa as a next generation periodontal soft tissue regeneration
2012 - 2014 The identification of maintenance mechanism of mesenchymal stem cells based on the niche concept of SCAP.
2012 - 2014 A search and evaluation of the peptides that control the connective tissue growth factor for the prevention and the treatment of osteoarthritis.
2010 - 2013 高脂血症治療薬;スタチンを応用した象牙質形成促進作用を持つ新規覆髄材の開発
2010 - 2012 変形性関節症ならびに軟骨分化におけるWISP-1遺伝子の機能解析
2011 - 2012 Development of a technic to generate somatic stem cells using a newly reprogramming method.
2011 - 2012 The functional analysis of WISP-1 gene in osteoarthritis and chondrogenic differentiation.
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Papers (82)：
Yao Weng, Ziyi Wang, Heriati Sitosari, Mitsuaki Ono, Hirohiko Okamura, Toshitaka Oohashi. O-GlcNAcylation regulates osteoblast differentiation through the morphological changes in mitochondria, cytoskeleton, and endoplasmic reticulum. BioFactors. 2024
Aung Ye Mun, Kentaro Akiyama, Ziyi Wang, Jiewen Zhang, Wakana Kitagawa, Teisaku Kohno, Ryuji Tagashira, Kei Ishibashi, Naoya Matsunaga, Tingling Zou, et al. Macrophages modulate mesenchymal stem cell function via tumor necrosis factor alpha in tooth extraction model. JBMR plus. 2024. 8. 8. ziae085
Mitsuhiro Yoneda, Hidetaka Ideguchi, Shin Nakamura, Zulema Arias, Mitsuaki Ono, Kazuhiro Omori, Tadashi Yamamoto, Shogo Takashiba. Resolvin D2-induced reparative dentin and pulp stem cells after pulpotomy in a rat model. Heliyon. 2024. 10. 13. e34206-e34206
Anh Tuan Dang, Mitsuaki Ono, Ziyi Wang, Ikue Tosa, Emilio Satoshi Hara, Akihiro Mikai, Wakana Kitagawa, Tomoko Yonezawa, Takuo Kuboki, Toshitaka Oohashi. Local E-rhBMP-2/β-TCP Application Rescues Osteocyte Dendritic Integrity and Reduces Microstructural Damage in Alveolar Bone Post-Extraction in MRONJ-like Mouse Model. International Journal of Molecular Sciences. 2024. 25. 12. 6648-6648
桑原実穂, 廣瀬一樹, 廣瀬一樹, 奥田龍一郎, HABUMUGISHA Janvier, 近藤星, FU Shanqi, 大野充昭, 古松毅之, 中田英二, et al. CCN3, a senescence marker of cartilage, correlate with osteoarthritis irrespective of age and weight bearing. 日本分子生物学会年会プログラム・要旨集(Web). 2023. 46th
北川若奈, 大野充昭, 大野充昭, 土佐郁恵, 石橋啓, 石橋啓, 窪木拓男, 窪木拓男, 大橋俊孝. Mechanism of delayed bone wound healing in mice long bone due to bone marrow aging using scRNA-seq. 日本補綴歯科学会誌(Web). 2023. 15
大森江, 大森江, 大野彩, 大野彩, 大野充昭, 大野充昭, 小山絵理, 徳本佳奈, 山本道代, 三野卓哉, et al. Relationship between gut microbiome and underweight and mortality of elderly people requiring nursing care. 日本補綴歯科学会誌(Web). 2022. 14
