2020 - 2022 Identification of key factors for tooth development using spatial transcriptomics
2019 - 2022 The clarification of bone formation and absorption mechanism in the bone marrow microenvironment
2018 - 2021 Understanding of molecular mechanisms of tooth development using iPS interference and application to tooth regeneration techniques
2018 - 2021 The functional analysis of WISP1 gene aimed at the prevention of osteoarthritis
2017 - 2021 Molecular understanding of the accumulation of mesenchymal stem cells in vivo by photo-manipulation techniques and its application to bone-related diseases
2018 - 2020 Elucidation of undifferentiated maintaining mechanism of stem cell towards the control of stem cell aging
2017 - 2020 Understanding of periodontal disease and peri-implantitis with stem cell disfunction
2017 - 2020 Application of artificial periosteum containing BMP-2 to the treatment of refractory bone disease and bone nonunion.
2016 - 2019 The development of bone regeneration therapy based on the clarification of mechanism of BMP-2 induced bone formation and resorption
2016 - 2019 A comprehensive search applying 16SrRNA sequencing analysis to investigate oral and intestinal flora causing malnutrition in the elderly
2016 - 2019 Bone regenerative therapy using Escherichia coli-derived rhBMP-2 adsorbed in beta-TCP.
2015 - 2019 Guided control of keratinized epithelial mucosa as a next generation periodontal soft tissue regeneration
2012 - 2014 The identification of maintenance mechanism of mesenchymal stem cells based on the niche concept of SCAP.
2012 - 2014 A search and evaluation of the peptides that control the connective tissue growth factor for the prevention and the treatment of osteoarthritis.
2010 - 2013 高脂血症治療薬;スタチンを応用した象牙質形成促進作用を持つ新規覆髄材の開発
2010 - 2012 変形性関節症ならびに軟骨分化におけるWISP-1遺伝子の機能解析
2011 - 2012 Development of a technic to generate somatic stem cells using a newly reprogramming method.
2011 - 2012 The functional analysis of WISP-1 gene in osteoarthritis and chondrogenic differentiation.
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Papers (77)：
Ziyi Wang, Satoru Hayano, Yao Weng, Xindi Mu, Mitsuaki Ono, Jeremie Oliver Piña, Rena N. D'Souza, Takashi Yamashiro, Toshitaka Oohashi, Hiroshi Kamioka. Filamin A mediates embryonical palatal fusion by linking mechanotransduction with β-Catenin/Smad2. 2024
Masaya Abe, Noboru Asada, Maiko Kimura, Chie Fukui, Daisuke Yamada, Ziyi Wang, Masayuki Miyake, Takeshi Takarada, Mitsuaki Ono, Michinori Aoe, et al. Antitumor activity of α-pinene in T-cell tumors. Cancer science. 2024
Eri Koyama, Aya Kimura-Ono, Takuya Mino, Yoko Kurosaki, Kana Tokumoto, Michiyo Yamamoto, Shinsuke Nakagawa, Suguru Osaka, Kumiko Nawachi, Mami Inoue-Minakuchi, et al. Does maintaining the number of present and functional teeth benefit the longevity of life in older people requiring nursing care?: A prospective cohort study. Journal of Prosthodontic Research. 2024
Angela Ruscitto, Peng Chen, Ikue Tosa, Ziyi Wang, Gan Zhou, Ingrid Safina, Ran Wei, Mallory M Morel, Alia Koch, Michael Forman, et al. Lgr5-expressing secretory cells form a Wnt inhibitory niche in cartilage critical for chondrocyte identity. Cell stem cell. 2023. 30. 9. 1179-1198
北川若奈, 大野充昭, 大野充昭, 土佐郁恵, 石橋啓, 石橋啓, 窪木拓男, 窪木拓男, 大橋俊孝. Mechanism of delayed bone wound healing in mice long bone due to bone marrow aging using scRNA-seq. 日本補綴歯科学会誌(Web). 2023. 15
北川若奈, 北川若奈, 大野充昭, 大野充昭, 土佐郁恵, 石橋啓, 石橋啓, 大橋俊孝, 窪木拓男, 窪木拓男. BMP-2 induces the formation of bone and marrow tissues with real hematopoetic function. 日本補綴歯科学会誌(Web). 2022. 14
石橋啓, 石橋啓, 大野充昭, 大野充昭, 土佐郁恵, 北川若奈, 北川若奈, 秋山謙太郎, 窪木拓男, 窪木拓男, et al. Effect of aging on bone marrow niche and sinusoidal basement membrane. 日本補綴歯科学会誌(Web). 2022. 14
