Matsubara Junichi

Research field (3)： Tumor diagnostics and therapeutics , Gastroenterology , Tumor biology

Research keywords (4)： Clinical Oncology , Cancer Genome Profiling , Cancer Stem Cell , Cancer Chemotherapy

Research theme for competitive and other funds (3)：

2022 - 2025 CDKN3 inhibitor as a new compound to overcome the resistance to cytotoxic chemotherapy
2019 - 2022 CDKN3 as a new target of anti-cancer treatment overcoming the resistance to cytotoxic chemotherapy
2016 - 2018 The mechanism of chemotherapy resistance in colon cancer stem cells and epithelial mesenchymal transition colon cancer cells

Papers (50)：

Shogo Yamamura, Masashi Kanai, Yasuhide Takeuchi, Natsuko Okita, Tomohiro Kondo, Masahiro Yoshioka, Junichi Matsubara, Shigemi Matsumoto, Manabu Muto. Response to capmatinib in a patient with neuroendocrine carcinoma of the gallbladder origin harboring MET amplification. International cancer conference journal. 2024. 13. 2. 83-87
Trang H. Nguyen Vu, Osamu Kikuchi, Shinya Ohashi, Tomoki Saito, Tomomi Ida, Yukie Nakai, Yang Cao, Yoshihiro Yamamoto, Yuki Kondo, Yosuke Mitani, et al. Combination therapy with WEE1 inhibition and trifluridine/tipiracil against esophageal squamous cell carcinoma. Cancer Science. 2023. 114. 12. 4664-4676
Junichi Matsubara, Kumi Mukai, Tomohiro Kondo, Masahiro Yoshioka, Hidenori Kage, Katsutoshi Oda, Ryo Kudo, Sadakatsu Ikeda, Hiromichi Ebi, Kei Muro, et al. First-Line Genomic Profiling in Previously Untreated Advanced Solid Tumors for Identification of Targeted Therapy Opportunities. JAMA Network Open. 2023. 6. 7. e2323336-e2323336
Tomohiro Kondo, Masashi Kanai, Junichi Matsubara, Daisuke Yamaguchi, Takashi Ura, Tadayuki Kou, Toshinao Itani, Motoo Nomura, Taro Funakoshi, Akira Yokoyama, et al. Association between homologous recombination gene variants and efficacy of oxaliplatin-based chemotherapy in advanced pancreatic cancer: prospective multicenter observational study. Medical oncology (Northwood, London, England). 2023. 40. 5. 144-144
Yohei Chiba, Kazuki Sudo, Yuki Kojima, Hitomi Okuma, Shinji Kohsaka, Ryunosuke Machida, Masahiko Ichimura, Kenta Anjo, Kazumi Kurishita, Natsuko Okita, et al. A multicenter investigator-initiated Phase 2 trial of E7090 in patients with advanced or recurrent solid tumor with fibroblast growth factor receptor (FGFR) gene alteration: FORTUNE trial. BMC Cancer. 2022. 22. 1

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MISC (41)：

近藤知大, 金井雅史, 山本佳宏, 福山啓太, 山田敦, 吉岡正博, 松原淳一, 松本繁己, 小杉眞司, 武藤学. 包括的がんゲノムプロファイリングにおける二次的所見疑いバリアントの絞り込み基準. 日本内科学会雑誌. 2022. 111. Suppl. 190-190
Tomohiro Kondo, Takahiro Yamada, Masahiro Yoshioka, Masakazu Nishigaki, Yoshihiro Yamamoto, Tadayuki Kou, Junichi Matsubara, Masashi Kanai, Shigemi Matsumoto, Manabu Muto, et al. Confirmatory germline testing for presumed germline pathogenic variants using tumor-only testing. JOURNAL OF CLINICAL ONCOLOGY. 2021. 39. 15
Tomohiro Kondo, Quy Pham Nguyen, Junichi Matsubara, Keita Fukuyama, Motoo Nomura, Taro Funakoshi, Mari Funakoshi, Hitomi Sakamoto, Kanami Ashida, Kumi Mukai, et al. Comprehensive genomic profiling for chemotherapy-naive advanced gastrointestinal malignancies. JOURNAL OF CLINICAL ONCOLOGY. 2020. 38. 4
野村基雄, 佐藤千尋, 玉置将司, 松原淳一, 藤井康太, 坂中克行, 角田茂, 山田香, 千草義継, 武藤学. 食道癌術後妊娠中に発生した吻合部再発に対し化学放射線療法を施行し生児を得た1例. 日本食道学会学術集会プログラム・抄録集. 2018. 72回. 341-341
近藤知大, 土井恵太郎, 佐藤千尋, 片岡滋貴, 玉置将司, 吉岡正博, 野村基雄, 天沼裕介, 松原淳一, 高忠之, et al. 大腿部皮下埋め込み型中心静脈ポートのカテーテル断裂を認めた1例. 日本癌治療学会学術集会抄録集. 2017. 55回. P46-7

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Education (2)：

2007 - 2011 Kyoto University Graduate School of Medicine
1994 - 2000 Kyoto University Faculty of Medicine

Work history (10)：

2024/01 - 現在 Kyoto University Graduate School of Medicine Department of Medical Oncology Associate Professor
2020 - 2024/01 Kyoto University Graduate School of Medicine Department of Therapeutic Oncology Senior Lecturer
2016 - 2019 Kyoto University Graduate School of Medicine Department of Therapeutic Oncology Program Specific Assistant Professor
2011/09 - 2016/03 Stanford University Institute for Stem Cell Biology & Regenerative Medicine Postdoctoral Researcher
2011/04 - 2013/03 Japan Society for the Promotion of Science Postdoctoral Researcher

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Committee career (2)：

2022/04 - 現在 Japanese Society of Medical Oncology Committee of Public Relations
2020/04 - 現在 Japanese Society of Medical Oncology Committee of Cancer Genome Medical Coordinater

Awards (11)：

2022/04 - 科学研究費助成事業(学術研究助成基金助成金) 基盤研究(C)(一般) 課題番号22K08012
2021/04 - 藤原記念財団少壮研究者奨励金
2019/04 - 科学研究費助成事業(学術研究助成基金助成金) 基盤研究(C)(一般) 課題番号19K08393
2016 - 日本学術振興会研究活動スタート支援課題番号16H06899
2012 - 上原記念生命科学財団海外留学助成金リサーチフェローシップ

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Association Membership(s) (9)：

The Molecular Biology Society of Japan , American Society of Clinical Oncology (ASCO) , American Association for Cancer Research (AACR) , 日本胃癌学会 , 日本癌治療学会 , 日本癌学会 , 日本臨床腫瘍学会 , 日本消化器病学会 , 日本内科学会

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