Rchr
J-GLOBAL ID：201601011273480469
Update date: Sep. 25, 2024
Yamagata Kazuya
Yamagata Kazuya
Affiliation and department：
Research field (1)：
Metabolism and endocrinology
Research keywords (4)：
糖尿病学
, 内科学
, 生化学
, 代謝学
Research theme for competitive and other funds (22)：
- 2023 - 2025 Elucidation of molecular mechanism of age-associated impaired insulin secretion by single cell analysis
- 2022 - 2025 消化器癌の革新的治療法開発を目指したハダカデバネズミ腸内細菌のマルチオミクス解析
- 2022 - 2025 Regulation of glucose metabolism by SIRT7
- 2019 - 2022 Identification of the metabolic roles of SIRT7 and the development of its regulation.
- 2019 - 2021 Molecular mechanism of metabolic regulation through protein acylations
- 2016 - 2019 Identification of the multifaceted metabolic roles of SIRT7
- 2014 - 2016 The pathophysiological role of pancreatic beta-cell hypoxia in the progression of diabetes
- 2013 - 2016 Molecular mechanism of diabetes mellitus based on beta-cell transcription factor network
- 2012 - 2014 Proteasomal regulation of HNF4 alpha protein by hypoxia in pancreatic beta-cells.
- 2009 - 2014 Genetic studies on unique phenotypes in MSM/Ms mouse strain
- 2011 - 2013 核小体因子SIRT7による脂質蓄積制御機構の解明
- 2009 - 2011 Development of amyloid^<13> C-MR imaging of the brain at 7T
- 2009 - 2011 Molecular mechanism of type 2 diabetes based on pancreatic-cell enriched transcription factors
- 2009 - 2010 Common roles of macrophage proliferation and polarization in type 2 diabetes and atherosclerosis.
- 2009 - 2009 MSM/Msマウスの疾患感受性・抵抗性に関する遺伝学的解析
- 2007 - 2008 Generation of novel biomarker for pancreatic hormone secretion using shedding form of collectrin
- 2005 - 2006 Molecular mechanism of insulin secretion by a novel target of HNF1 colectrin
- 2003 - 2004 Study of glucose metabolism by HNF4α with knockout mouse
- 2002 - 2004 A novel classification of type 2 diabetes based on genome informatics
- 2001 - 2002 Identification of molecular mechanism of pancreatic β-cell development and growth by hepatocyte nuclear factors(HNFs)
- 2001 - 2001 Genome informaticsに基づいた新しい糖尿病の分類体系の確立
- 2000 - 2001 Establishment of the method for gene therapy of β cell regeneration by non-invasive gene delivery via pancreatic duct
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Papers (158)：
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Kazuya Yamagata, Tomonori Tsuyama, Yoshifumi Sato. Roles of β-Cell Hypoxia in the Progression of Type 2 Diabetes. International Journal of Molecular Sciences. 2024. 25. 8. 4186-4186
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Kazuya Yamagata, Tomoya Mizumoto, Tatsuya Yoshizawa. The Emerging Role of SIRT7 in Glucose and Lipid Metabolism. Cells. 2023. 13. 1. 48-48
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Tomonori Tsuyama, Yoshifumi Sato, Tatsuya Yoshizawa, Takaaki Matsuoka, Kazuya Yamagata. Hypoxia causes pancreatic β-cell dysfunction and impairs insulin secretion by activating the transcriptional repressor BHLHE40. EMBO reports. 2023. e56227
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羽根田 昌樹, 福田 一起, 宮川 克俊, 清原 由紀夫, 古賀 荒太郎, 水流添 覚, 古川 昇, 津山 友徳, 阪口 雅司, 瀬ノ口 隆文, et al. 日本人の加齢による2型糖尿病発症機序の解明(合志スタディ). 糖尿病. 2023. 66. Suppl.1. S-172
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Masaya Yamazaki, Shinjiro Hino, Shingo Usuki, Yoshihiro Miyazaki, Tatsuya Oda, Mitsuyoshi Nakao, Takaaki Ito, Kazuya Yamagata. YAP/BRD4-controlled ROR1 promotes tumor-initiating cells and hyperproliferation in pancreatic cancer. EMBO J. 2023. 42. 14. e112614
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MISC (225)：
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羽根田昌樹, 福田一起, 福田一起, 宮川克俊, 清原由紀夫, 古賀荒太郎, 水流添覚, 古川昇, 津山友徳, 津山友徳, et al. 日本人の加齢による2型糖尿病発症機序の解明(合志スタディ). 糖尿病(Web). 2023. 66. Suppl
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佐藤 叔史, 津山 友徳, 吉澤 達也, 井上 正宏, 山縣 和也. 膵β細胞における低酸素誘導因子BHLHE40の機能解析. 生命科学系学会合同年次大会. 2017. 2017年度. [2P-1034]
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吉澤 達也, 山縣 和也. SIRT7による代謝・老化関連疾患制御 (特集 糖尿病患者の健康寿命延伸を目指して : 老化関連因子サーチュイン・AGEs・p53と寿命). 糖尿病. 2017. 9. 3. 60-69
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佐藤 叔史, 井上 正宏, 吉澤 達也, 山縣 和也. β細胞低酸素による転写因子HNF-4α蛋白低下メカニズムの検討. 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集. 2015. 88回・38回. [2P1214]-[2P1214]
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佐藤 叔史, 佐藤 ちなみ, 吉澤 達也, 井上 正宏, 山縣 和也. β細胞低酸素による転写因子HNF4α蛋白発現低下機序の検討. 糖尿病. 2015. 58. Suppl.1. S-442
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Professional career (1)：
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