Daisuke Kami

Research field (1)： Molecular biology

Research theme for competitive and other funds (22)：

2022 - 2025 Development of a vascular prothesis regenerated in the patient's body using a decellularized xenogeneic cell-free device
2022 - 2025 Attempt to use skin tissue killed by high-pressure treatment technology as autologous regenerative vascular grafts
2022 - 2025 Development of Mitochondrial Disease Therapy by Mitochondrial DNA Replacement in Hematopoietic Stem Cells
2020 - 2025 A multifaceted study aiming at expanding the clinical application of autologous in vivo-tissue engineered vascular grafts
2021 - 2024 Development of an Optimal Chemical Processing for Allogeneic In Vivo Tissue Engineered Vascular Grafts

2021 - 2024 Construction of Multiple Sample Analysis System Using FRET System and Search for Inhibitors of Virus Polymerization Proteins

2019 - 2024 Pulmonary artery enlargement for congenital heart disease using connective tissue membrane using in vivo tissue engineering

2020 - 2023 Development of allogeneic in vivo-tissue engineered vascular graft preparation completed in the operating room without using special facilities

2019 - 2023 高圧処理化自家皮膚組織の”自己体内再生型”血管補填材料としての応用

2018 - 2022 Development of an optimal treatment method for using biomaterials as cardiovascular prostheses

2019 - 2021 Neutralizing antibody producing B cell deletion by CAR technology in Lysosomal diseases

2018 - 2021 RNA metabolism during cellular transition

2017 - 2021 Development of vascular grafts for auto implantation rapidly formed in patients using xenogeneic decellularized connective tissue tubules as scaffolds

2016 - 2020 Development of xenogeneic decellularized biotubes for off-the-shelf applications

2016 - 2019 In vivo gene editing in the adult kidney by CRISPR/Cas9 technique

2016 - 2019 Diversified deployment of "self-regenerating" connective tissue vascular grafts "Biotubes" for clinical applications.

2014 - 2018 Analysis of Cardiac specific lncRNAs

2014 - 2017 Development of Isolated Mitochondria Transplantation

2014 - 2017 Evaluation method for analysis of heating mechanism of intercellular magnetic nanoparticles

2013 - 2016 Whole Heart Engineering with Decellularization and in vivo Incubation

2010 - 2012 Regenerative medicine for heart failure in large animal models

2009 - 2012 Definition of human cardiomyogenic differentiation factor

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Papers (65)：

Yosuke Suzuki, Daisuke Kami, Toshihiko Taya, Arata Sano, Takehiro Ogata, Satoaki Matoba, Satoshi Gojo. ZLN005 improves the survival of polymicrobial sepsis by increasing the bacterial killing via inducing lysosomal acidification and biogenesis in phagocytes. Frontiers in immunology. 2023. 14. 1089905-1089905
山南将志, 神田圭一, 権代竜郎, 川尻英長, 井上知也, 渡辺太治, 上大介, 五條理志, 前田吉宣, 小田晋一郎, et al. 生体吸収性素材の現状と医用への応用生体内組織工学技術を用いて患者皮下で作製する自家結合組織血管移植片の臨床応用拡大のための試み. 人工臓器. 2022. 51. 2. S-92
権代竜郎, 山南将志, 神田圭一, 井上知也, 川尻英長, 渡辺太治, 上大介, 五條理志, 夜久均. 同種由来生体材料を血管移植片として用いるための脱細胞化処理方法最適化の試み. 人工臓器. 2022. 51. 2. S-215
Daisuke Miyawaki, Hiroyuki Yamada, Makoto Saburi, Naotoshi Wada, Shinichiro Motoyama, Takeshi Sugimoto, Hiroshi Kubota, Noriyuki Wakana, Daisuke Kami, Takehiro Ogata, et al. Maternal high-fat diet promotes calcified atherosclerotic plaque formation in adult offspring by enhancing transformation of VSMCs to osteochondrocytic-like phenotype. Heliyon. 2022. 8. 9. e10644
Daisuke Kami, Toshimasa Ishizaki, Toshihiko Taya, Akira Katoh, Hiroyuki Kouji, Satoshi Gojo. A novel mRNA decay inhibitor abolishes pathophysiological cellular transition. Cell death discovery. 2022. 8. 1. 278-278

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MISC (38)：

Gondai T, Yamanami M, Kanda K, Inoue T, Kawajiri H, Watanabe T, Kami D, Gojo S, Yaku H. IMPROVEMENT OF THE SIMPLER AND SHORTER DECELLULARIZATION PROCEDURE OF IN VIVO TISSUE ENGINEERED VASCULAR GRAFT USED FOR ALLOGENEIC TRANSPLANTATION. International J Artif. Org. 2022. 45. 9. 786-787
Keiichi Kanda, Masashi Yamanami, Tomoya Inoue, Daisuke Kami, Satoshi Gojo, Hitoshi Yaku. IN VIVO TISSUE ENGINEERED VASCULAR GRAFTS ADAPTABLE TO AV SHUNTS. International J Artif. Org. 2019
Tomoya Inoue, Keiichi Kanda, Masashi Yamanami, Daisuke Kami, Satoshi Gojo, Hitoshi Yaku. MODIFICATIONS OF MECHANICAL PROPERTIES OF IN VIVO TISSUE ENGINEERED VASCULAR TISSUES BY SHORT PERIOD OF CHEMICAL TREATMENTS. International J Artif. Org. 2019
Masashi Yamanami, Keiichi Kanda, Kazuki Morimoto, Inoue Inoue, Taiji Watanabe, Osamu Sakai, Daisuke Kami, Satoshi Gojo, Hitoshi Yaku. APPLICATION OF IN VIVO TISSUE ENGINEERED DECELLULARIZED CONNECTIVE TISSUE FOR CARDIOVASCULAR GRAFTS. International J Artif. Org. 2019
Masashi Yamanami, Keiichi Kanda, Kazuki Morimoto, Inoue Inoue, Taiji Watanabe, Osamu Sakai, Daisuke Kami, Satoshi Gojo, Hitoshi Yaku. DEVELOPMENT OF DECELLULARIZED IN VIVO TISSUE ENGINEERED VASCULAR GRAFTS. International J Artif. Org. 2019

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