Research field (2)：
Veterinary medicine
, Veterinary medicine
Research keywords (3)：
Immune Escape
, Cancer Immunology
, Veterinary Clinical Pathology
Research theme for competitive and other funds (6)：
2023 - 2026 Development of a novel treatment targeting the immunosuppressive mechanism of MDSC for canine malignant melanoma
2019 - 2023 Research and development for practical use of individualized canine cancer immunotherapy
2019 - 2022 担がん犬における骨髄由来抑制細胞を標的とした新規治療候補薬の探索
2015 - 2018 Studies on the mechanisms and therapeutic approach for resistance of tyrosine kinase inhibitors in mast cell tumour
2015 - 2017 Establishment of new immunotherapy targeting novel co-inhibitory molecule DC-HIL against canine malignant melanoma
2008 - 2010 自然発生癌宿主における樹状細胞ワクチン低反応性メカニズムの解明
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Papers (40)：
Masanori Kobayashi, Moe Onozawa, Shiho Watanabe, Tomokazu Nagashima, Kyoichi Tamura, Yoshiaki Kubo, Akiko Ikeda, Kazuhiko Ochiai, Masaki Michishita, Makoto Bonkobara, et al. Establishment of a BRAF V595E-mutant canine prostate cancer cell line and the antitumor effects of MEK inhibitors against canine prostate cancer. Veterinary and comparative oncology. 2023
Hiroyuki Tani, Ryo Miyamoto, Teruki Miyazaki, Shingo Oniki, Kyoichi Tamura, Makoto Bonkobara. A feline case of multiple myeloma treated with bortezomib. BMC veterinary research. 2022. 18. 1. 384-384
Hiroyuki Tani, Ryo Miyamoto, Tomokazu Nagashima, Masaki Michishita, Kyoichi Tamura, Makoto Bonkobara. Molecular characterization of canine SHP2 mutants and anti-tumour effect of SHP2 inhibitor, SHP099, in a xenograft mouse model of canine histiocytic sarcoma. Veterinary and comparative oncology. 2021. 20. 1. 109-117
Hiroyuki Tani, Ryo Miyamoto, Syunya Noguchi, Sena Kurita, Tomokazu Nagashima, Masaki Michishita, Naoko Yayoshi, Kyoichi Tamura, Makoto Bonkobara. A canine case of malignant melanoma carrying a KIT c.1725_1733del mutation treated with toceranib: a case report and in vitro analysis. BMC veterinary research. 2021. 17. 1. 147-147
