Chihara Norio

チハラノリオ | Chihara Norio

Affiliation and department：
Job title： Project Associate Professor

Research field (2)： Immunology , Neurology

Research keywords (12)： Blood brain barrier , Dementia , Systems biology , Neuroimmunological diseases , Neuromyelitis Optica , Neuroimmunology , Multiple Sclerosis , Immune tolerance , co-inhibitory molecules , B cells , T cells , autoimmunity

Research theme for competitive and other funds (4)：

2023 - 2027 免疫性神経疾患の神経変性過程を再現する脳内炎症環境モデルの構築
2020 - 2023 Elucidation of neurodegenerative pathology using regulatory gene program of T cells in immune neurological diseases
2020 - 2023 視神経脊髄炎の個別化医療を目指した免疫寛容システムの解明
2018 - 2020 Elucidation of progressive pathology using PD-1 positive T cells in multiple sclerosis

Papers (104)：

Fumio Takano, Kaori Ueda, Norio Chihara, Mina Arai, Mari Sakamoto, Takuji Kurimoto, Yuko Yamada-Nakanishi, Makoto Nakamura. Leber hereditary optic neuropathy “plus” with the m.14487 T>C mutation as the causality of hemidystonia: A Case Report. Case Reports in Ophthalmology. 2024
Sotaro Mori, Norio Chihara, Yuto Iwaki, Mina Okuda-Arai, Fumio Takano, Kaori Ueda, Mari Sakamoto, Yuko Yamada-Nakanishi, Riki Matsumoto, Makoto Nakamura. Evaluation of Brain and Spinal Cord Lesions and Cerebrospinal Fluid Analysis in Detecting Demyelinating Diseases in Patients with Optic Neuritis. Neuro-Ophthalmology. 2024
Kenji Sekiguchi, Seiji Kawano, Norio Chihara, Seimi Satomi-Kobayashi, Eiichi Maeda, Riki Matsumoto. Live Streaming of the Professor’s Ward Rounds in Undergraduate Neurology Education: Usability Study. JMIR Formative Research. 2024
Masaaki Niino, Noriko Isobe, Manabu Araki, Takashi Ohashi, Tomoko Okamoto, Mieko Ogino, Tatsusada Okuno, Hirofumi Ochi, Izumi Kawachi, Yuko Shimizu, et al. Clinical practice guidelines for multiple sclerosis, neuromyelitis optica spectrum disorder, and myelin oligodendrocyte glycoprotein antibody-associated disease 2023 in Japan. Multiple Sclerosis and Related Disorders. 2024
Ritsu Akatani, Norio Chihara, Atsushi Hara, Asato Tsuji, Shusuke Koto, Kazuhiro Kobayashi, Tatsushi Toda, Riki Matsumoto. Interleukin-6 Signaling Blockade Induces Regulatory Plasmablasts in Neuromyelitis Optica Spectrum Disorder. Neurology(R) neuroimmunology & neuroinflammation. 2024. 11. 4. e200266

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MISC (1)：

佐藤和貴郎, 荒浪利昌, 冨田敦子, 千原典夫, 岡本智子, 林幼偉, 村田美穂, 三宅幸子, 山村隆. Human Immunology 疾患理解から治療へ多発性硬化症における脳脊髄液T細胞のケモカイン受容体解析. 神経免疫学. 2013. 18. 1. 68-68

Patents (1)：

Modulation of novel immune checkpoint targets

Books (1)：

多発性硬化症(MS)診療のすべて
診断と治療社 2012 ISBN:9784787818188

Lectures and oral presentations (217)：

側脳室周囲に造影効果病変を伴った視神経脊髄炎スペクトラム障害(NMOSD)の一例
(臨床神経学 2024)
同側顔面および上肢の感覚障害をきたした後脊髄動脈領域梗塞の一例
(臨床神経学 2024)
The role of IL-6 in NMOSD: pathogenesis and therapeutic implication
(2023 Annual Meeting of the Taiwan Neuroimmunology Medical Society 2023)
Clinical Experience with Satralizumab and Steroid Tapering in the Treatment of NMOSD
(2023 TNMS Dinner Symposium 2023)
多発性硬化症と視神経脊髄炎の病態と新たな治療戦略
(日本臨床免疫学会総会プログラム・抄録集 2023)

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Education (2)：

- 2012 Kobe University Graduate School of Medicine
- 2004 Kobe University School of Medicine

Professional career (1)：

博士(医学) (神戸大学)

Work history (6)：

2022/04 - 現在 Kobe University University Hospital Neurosurgery Project associate professor
2018/06 - 2022/03 Kobe University Hospital Division of Neurology Assistant professor
2016/04 - 2018/06 Kobe University Hospital Division of Neurology Assistant professor
2013/04 - 2016/03 Brigham and Women's Hospital Postdoctoral research fellow
2013/04 - 2016/03 Harvard Medical School Research fellow

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Committee career (5)：

2022/10 - 現在日本臨床免疫学会 Midwinter Seminar小委員会委員
2022/10 - 現在 The Japanese Society of Clinical Immunology Representative
2020/08 - 現在厚生労働省難治性疾患政策研究事業神経免疫疾患のエビデンスに基づく診断基準・重症度分類・ガイドラインの妥当性と患者QOLの検証研究班研究協力者
2020/07 - 現在日本神経学会多発性硬化症・視神経脊髄炎ガイドライン作成委員会委員
2019/09 - 現在 The Japanese Society for Neuroimmunology Councilor

Awards (8)：

2020/12 - 神戸大学優秀若手研究者賞
2019/10 - 内藤記念科学振興財団 2019年度科学奨励金・研究助成認知症を呈する自己免疫性辺縁系脳炎の病態解明(自己免疫介在性認知症の病態解明)
2019/08 - 神戸大学医学部第7回神緑会Young Investigator Award 最優秀賞
2018/12 - 上原記念生命科学財団 2018年度研究助成金神経免疫疾患におけるCysltr1 の免疫寛容機構の解明
2014/03 - 日本学術振興会平成26年度海外特別研究員ヒト化TおよびB細胞受容体ダブルトランスジェニックマウスを用いたNMO病態の解明

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Association Membership(s) (5)：

The Japanese Society of Internal Medicine , INTERNATIONAL SOCIETY OF NEUROIMMUNOLOGY , JAPANESE SOCIETY FOR NEUROIMMUNOLOGY , THE JAPAN SOCIETY FOR CLINICAL IMMUNOLOGY , JAPANESE SOCIETY OF NEUROLOGY

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