Masahiro Hiasa | Researcher Information

2023 - 2027 骨細胞保護によるがんの骨転移新規治療戦略の開発
2021 - 2025 骨破壊腫瘍進展と骨病変形成における細胞内情報伝達系の恒常的活性化機構の解明と制御
2019 - 2022 免荷によるがん進展、再発・転移加速化の分子メカニズムの解明とその治療への挑戦
2018 - 2021 Fabrication of direct bonding material for easily debonding on demand
2017 - 2021 Elucidation of the pathogenesis of bone diseases mediated by osteocyte-sensory nerve networks

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Yusuke Inoue, Asuka Oda, Yusaku Maeda, Ryohei Sumitani, Masahiro Oura, Kimiko Sogabe, Tomoko Maruhashi, Mamiko Takahashi, Shiro Fujii, Shingen Nakamura, et al. Ex vivo expansion and activation of Vγ9Vδ2 T cells by CELMoDs in combination with zoledronic acid. International journal of hematology. 2024
Kimiko Sogabe, Shingen Nakamura, Yoshiki Higa, Hirokazu Miki, Asuka Oda, Tomoko Maruhashi, Ryohei Sumitani, Masahiro Oura, Mamiko Takahashi, Masafumi Nakamura, et al. Acute accumulation of PIM2 and NRF2 and recovery of β5 subunit activity mitigate multiple myeloma cell susceptibility to proteasome inhibitors. International journal of hematology. 2024. 119. 3. 303-315
Masahiro Hiasa, Itsuro Endo, Toshio Matsumoto. Bone-fat linkage via interleukin-11 in response to mechanical loading. Journal of Bone and Mineral Metabolism. 2024
Tatsuo Okui, Masahiro Hiasa, Kenji Hata, G David Roodman, Masako Nakanishi, Toshiyuki Yoneda. The acid-sensing nociceptor TRPV1 controls breast cancer progression in bone via regulating HGF secretion from sensory neurons. Research square. 2023
Emiko Nakaue, Jumpei Teramachi, Hirofumi Tenshin, Masahiro Hiasa, Takeshi Harada, Asuka Oda, Yusuke Inoue, So Shimizu, Yoshiki Higa, Kimiko Sogabe, et al. Mechanisms of preferential bone formation in myeloma bone lesions by proteasome inhibitors. International journal of hematology. 2023. 118. 1. 88-98

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中上絵美子, 寺町順平, 天真寛文, 日浅雅博, 清水宗, 比嘉佳基, 田中茉里子, 金秀河, 中川宗純, 田中栄二, et al. プロテアソーム阻害薬による骨髄腫骨病変部における骨形成のメカニズム. 日本矯正歯科学会大会プログラム・抄録集. 2023. 82回. 192-192
比嘉佳基, 日浅雅博, 中川宗純, 金秀河, 田中茉里子, 中上絵美子, 清水宗, 天真寛文, 田中栄二, 安倍正博. KEAP1-NRF2軸を介した脂肪細胞分化と骨芽細胞分化の制御機構. 日本矯正歯科学会大会プログラム・抄録集. 2023. 82回. 194-194
堀内信也, 中上絵美子, 渡邉佳一郎, 日浅雅博, 田中栄二. 顎間関係を判断するAIにおける判定根拠に関する検討. 日本矯正歯科学会大会プログラム・抄録集. 2023. 82回. 208-208
原田武志, 小田明日香, 住谷龍平, 井上雄介, 原倫世, 大浦雅博, 曽我部公子, 丸橋朋子, 高橋真美子, 藤井志朗, et al. 1q増幅骨髄腫微小環境でのSLAMF7が介在する炎症ネットワーク. 日本血液学会学術集会. 2023. 85回. 41-41
中川宗純, 日浅雅博, 花輪茂己, 金秀河, 比嘉佳基, 松木佑太, 堀内信也, 田中栄二. 上顎骨前方部延長術を行った口唇口蓋裂患者2症例の術後評価. 中・四国矯正歯科学会雑誌. 2023. 35. 1. 112-113

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ベンジルアミン誘導体

Apoptosis inducer TRAIL stimulates osteoclast differentiation and survival via TAK1 activation.
(The 4th ASEAN plus Tokushima Joint International Conference 2017)
Disruption of myeloma cell-bone marrow interaction by TAK-1 inhibition
(第80回日本血液学会学術集会 2017)
徳島大学病院矯正歯科患者における永久歯埋伏に関する臨床統計学的調査
(第76回日本矯正歯科学会学術大会 2017)
TAK1 inhibition impairs myeloma cell-bone marrow interaction to reduce myeloma tumor growth and bone destruction
(American Society for Bone and Mineral Research (ASBMR) 2017 Annual Meeting 2017)
Decreased bone strength induced by persistent activation of calcium-sensing receptor
(American Society for Bone and Mineral Research (ASBMR) 2017 Annual Meeting 2017)

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2008 - 徳島大学大学院口腔科学教育部口腔科学専攻博士課程修了

歯学 (徳島大学)

2019/08 - 現在 The University of Tokushima
2018/04 - 2019/07 The University of Tokushima
2015/04 - 2018/03 The University of Tokushima
2008/04 - 2015/03 The University of Tokushima Institute of Health Biosciences The University of Tokushima Graduate School

Japanese Society for Bone and Mineral Research Editrial Boad
Chu-Shikoku Orthodontic Society 編集理事

2021/09/25 - Japanese Society of Hematology 第83回日本血液学会学術集会優秀ポスター賞 The critical roles of the TAK1-CIP2A axis in MM cell growth and survival and osteoclastogensis
2021/09/25 - Japanese Society of Hematology 第83回日本血液学会学術集会優秀ポスター賞 Critical roles of the XO-ROS axis in the pathology of bone loss in myeloma
2019/07/26 - Japanese Society for Bone and Mineral Research 第36回日本骨代謝学会学術集会研究奨励賞. カテプシンK阻害による多発性骨髄腫骨病変部の骨量回復プロセスにおける骨細胞の役割
2018/07/27 - Japanese Society for Bone and Mineral Research 研究奨励賞
2017/06/17 - Australian and New Zealand Bone and Mineral Society ANZBMS Plenary Poster Award. Osteoclasts utilize TRAIL for their NF-B activation, but TAK1 inhibition resumes TRAIL-induced apoptosis in osteoclasts.

2017/06 - Australian and New Zealand Bone and Mineral Society. ANZBMS Plenary Poster Award. Osteoclasts utilize TRAIL for their NF-B activation, but TAK1 inhibition resumes TRAIL-induced apoptosis in osteoclasts.

2017/05/16 - European Calcified Tissue Society East Meets West award Bone pain-modifying actions of osteocytes via Connexin43-mediated communications with sensory nerves

2017/05 - European Calcified Tissue Society. East Meets West award. Bone pain-modifying actions of osteocytes via Connexin43-mediated communications with sensory nerves.

2016/09/18 - The American Society for Bone and Mineral Research ASBMR Young Investigator Award Osteocytes Mediate Bone Pain Through Cell-Cell Communication with Sensory Neurons via Connexin 43

2016/09 - The American Society for Bone and Mineral Research. ASBMR Young Investigator Award. Osteocytes Mediate Bone Pain Through Cell-Cell Communication with Sensory Neurons via Connexin 43.

2016/07/21 - Japanese Society for Bone and Mineral Research 第34回日本骨代謝学会学術集会・第3回アジア太平洋骨代謝学会議,Young investigator award. 破骨細胞はTAK1の発現誘導を介しアポトーシスを抑制しTRAILにより成熟活性化される

2014/09/12 - The American Society for Bone and Mineral Research ASBMR plenary poster Osteocytes directly communicate with sensory neuronal cells via cell-cell networks that are modulated under an acidic microenvironment

2014/09/12 - The American Society for Bone and Mineral Research ASBMR young investigator Travel Grant Osteocytes directly communicate with sensory neuronal cells via cell-cell networks that are modulated under an acidic microenvironment

2014/09 - The American Society for Bone and Mineral Research. ASBMR plenary poster. Osteocytes directly communicate with sensory neuronal cells via cell-cell networks that are modulated under an acidic microenvironment.

2014/09 - The American Society for Bone and Mineral Research. ASBMR young investigator Travel Grant. Osteocytes directly communicate with sensory neuronal cells via cell-cell networks that are modulated under an acidic microenvironment.

2013/10 - The American Society for Bone and Mineral Research Plenary poster & Young Investigator Travel Award 5. Potent induction of bone formation in myeloma bone lesions by the cathepsin K inhibitor KK1-300-01 in combinat ion with the proteasome inhibitor bortezomib.

2013/10 - The American Society for Bone and Mineral Research. Plenary poster & Young Investigator Travel Award. Potent induction of bone formation in myeloma bone lesions by the cathepsin K inhibitor KK1-300-01 in combinat ion with the proteasome inhibitor bortezomib.

2012/11/09 - 日本白血病研究基金一般研究賞(日本血液学会推薦) 骨髄腫の薬剤耐性と骨破壊病変形成におけるセリンスレオニンキナーゼPim-2の役割とPim-2を標的とした新規骨髄腫治療法の開発

2012/10/19 - 日本血液学会日本血液学会奨励賞 Pimキナーゼ阻害による腫瘍進展と骨破壊の抑制

2012/09/05 - ANZBMS Young Investigator Award, 2012 The cathepsin K inhibitor KK1-300-01 prevents bone destruction and resumes bone formation in myeloma osteolytic lesions

2011/09/21 - The American Society for Bone and Mineral Research ASBMR Young Investigator Travel Grant. Prevention of tumor growth and bone destruction in myeloma by Pim kinase inhibition.

2011/09/16 - The American Society for Bone and Mineral Research ASBMR young investigator Travel Grant Prevention of tumor growth and bone destruction in myeloma by Pim kinase inhibition.

2011/07/30 - Japanese Society for Bone and Mineral Research 高得点演題賞 Pimキナーゼの阻害は骨芽細胞分化を促進し,骨髄腫骨病変の形成と腫瘍進展を抑制する

2011/07/30 - 第29回日本骨代謝学会優秀演題賞 Pimキナーゼの阻害は骨芽細胞分化を促進し,骨髄腫骨病変の形成と腫瘍進展を抑制する

2011/07/29 - Japanese Society for Bone and Mineral Research 優秀演題賞 Pimキナーゼの阻害は骨芽細胞分化を促進し,骨髄腫骨病変の形成と腫瘍進展を抑制する

2011/07/29 - Japanese Society for Bone and Mineral Research IOF-ANZBMS Travel Award Pimキナーゼの阻害は骨芽細胞分化を促進し,骨髄腫骨病変の形成と腫瘍進展を抑制する

2011/07/28 - Faculty of Dentistry 歯学部優秀研究賞

2011/07/28 - Japanese Society for Bone and Mineral Research 高得点演題賞 Pimキナーゼの阻害は骨芽細胞分化を促進し,骨髄腫骨病変の形成と腫瘍進展を抑制する

2011/07/17 - Japanese Association for Dental Research IOF-ANZBMS Travel Award. Dual effects of Pim inhibition on myeloma: induction of bone formation and tumor suppression

2010/12/06 - 52nd ASH 52nd ASH Travel Award An acidic milieu created in myeloma-osteoclast interaction enhances tumor growth, but triggers anti-myeloma activity of Reveromycin A, a novel anti-resorptive agent

2010/10/22 - Faculty of Dentistry 高田充歯科基礎医学学術奨励賞

2010/10/15 - The American Society for Bone and Mineral Research ASBMR plenary poster Bone Marrow Stromal Cells Suppress TACE-mediated M-CSFR and RANK Shedding to Facilitate Osteoclastogenesis and Suppress DC Differentiation from Monocytes.

2010/10/15 - The American Society for Bone and Mineral Research ASBMR young investigator Travel Grant Bone Marrow Stromal Cells Suppress TACE-mediated M-CSFR and RANK Shedding to Facilitate Osteoclastogenesis and Suppress DC Differentiation from Monocytes.

2010/09/22 - 10th International Conference Cancer-Induced Bone Disease Travel Grant Award, 2010. The novel anti-resorptive agent reveromycin A ameliorates bone destruction and tumor growth in myeloma

2010 - 2010 ASBMR Young Investigator Award, 2010. TA novel anti-resorptive agent, reveromycin A, ameliorates bone destruction and tumor growth in myeloma

2009/11/07 - 内藤記念財団第26回内藤コンファランス優秀ポスター Bone marrow stromal cells inhibit dendritic cell differentiation and facilitate osteoclastogenesis in myeloma through the suppression of M-CSF receptor shedding in monocytes

2008/03 - Tokushima University 康楽賞

2008/03 - Tokushima University 徳島大学学長表彰

2006/07/06 - 先端歯学スクール優秀賞

2006/07/06 - Japanese Society for Bone and Mineral Research IOF-ANZBMS Travel Award

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