Yamanishi Yoshihiro

ヤマニシヨシヒロ | Yamanishi Yoshihiro

Affiliation and department：
Job title： Professor
Homepage URL (2)： https://yamanishi.cs.i.nagoya-u.ac.jp/index_J.html , https://yamanishi.cs.i.nagoya-u.ac.jp/

Research field (3)： Biological, health, and medical informatics , Statistical science , Pharmaceuticals - chemistry and drug development

Research keywords (12)：バイオインフォマティクス , ケモインフォマティクス , システム生物学 , 機械学習 , 統計学 , 標的分子 , 代謝パスウェイ , 遺伝子ネットワーク , 化学反応 , カーネル法 , インシリコ創薬 , ドラッグリポジショニング

Research theme for competitive and other funds (17)：

2021 - 2026 Development of innovative AI methods for predicting therapeutic targets for intractable diseases from medical big data
2023 - 2025 Pure transformer encoder-based generative adversarial networks for molecular generation
2021 - 2024 Creation of data-driven direct reprogramming by AI and avoidance of tumorigenic risk
2020 - 2023 Synergy pharmaceutical science: understanding and design of compound combination effects by integrating information, material, and life sciences
2020 - 2023 Synergy pharmaceutical science: understanding and design of compound combination effects by integrating information, material, and life sciences

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Papers (107)：

Momoko Hamano, Toru Nakamura, Ryoku Ito, Yuki Shimada, Michio Iwata, Jun-ichi Takeshita, Ryohei Eguchi, Yoshihiro Yamanishi. DIRECTEUR: Transcriptome-based prediction of small molecules that replace transcription factors for direct cell conversion. Bioinformatics. 2024
Shogo Taniguchi, Francois Berenger, Yukako Doi, Ayana Mimura, Yoshihiro Yamanishi, Tsukasa Okiyoneda. Ligand-based virtual-screening identified a novel CFTR ligand which improves the defective cell surface expression of misfolded ABC transporters. Frontiers in pharmacology. 2024. 15. 1370676-1370676
Md Mamunur Rashid, Momoko Hamano, Midori Iida, Michio Iwata, Toshiyuki Ko, Seitaro Nomura, Issei Komuro, Yoshihiro Yamanishi. Network-based identification of diagnosis-specific trans-omic biomarkers via integration of multiple omics data. Biosystems. 2024. 105122-105122
Zhehao Dai, Toshiyuki Ko, Kanna Fujita, Seitaro Nomura, Yukari Uemura, Kenji Onoue, Momoko Hamano, Manami Katoh, Shintaro Yamada, Mikako Katagiri, et al. Myocardial DNA Damage Predicts Heart Failure Outcome in Various Underlying Diseases. JACC: Heart Failure. 2023
Takuya Okada, Kaho Yamabe, Michiko Jo, Yuko Sakajiri, Tomokazu Shibata, Ryusuke Sawada, Yoshihiro Yamanishi, Daisuke Kanayama, Hisashi Mori, Mineyuki Mizuguchi, et al. Design and structural optimization of thiadiazole derivatives with potent GLS1 inhibitory activity. Bioorganic & medicinal chemistry letters. 2023. 93. 129438-129438

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MISC (179)：

難波里子, 岩田通夫, 山西芳裕. Prediction of therapeutic target molecules using genetically perturbed omics data. 実験医学. 2023. 41. 7. 1193-1199
山本真, 菅泰彦, 武田吉人, 中坪大亮, 榎本貴俊, 吉村華子, 網屋沙織, 原伶奈, 川崎貴裕, 白山敬之, et al. 肺癌効果予測因子血清エクソソームの最新プロテオミクスによる小細胞肺癌の新規バイオマーカーの探索. 日本呼吸器学会誌. 2023. 12. 増刊. 194-194
戴哲皓, 候聡志, 野村征太郎, 藤田寛奈, 濱野桃子, 山西芳裕, 尾上健児, 小室一成. 心筋組織におけるDNA損傷は原疾患によらず左室駆出率の低下した心不全の治療反応及び予後を予測する. 日本内科学会雑誌. 2023. 112. 臨増. 144-144
濱野桃子, 中村透, 岩田通夫, 江口凌平, 竹下潤一, 山西芳裕. ダイレクトリプログラミングを誘導する低分子化合物組み合わせのin silico予測. 日本再生医療学会総会(Web). 2023. 22nd
山西芳裕. 最先端の研究技術を基盤とした心脈管作動物質研究の未来 AIが拓く創薬と医療循環器疾患への応用に向けて. 血管. 2023. 46. 1. 36-36

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Books (1)：

Chemoinformatics and Advanced Machine Learning Perspectives
IGI Global 2010

Professional career (1)：

PhD (Kyoto University)

Work history (9)：

2023/04 - 現在 Nagoya University Department of Complex Systems Science, Graduate School of Informatics Professor
2018/06 - 2023/03 Kyushu Institute of Technology Faculty of Computer Science and Systems Engineering Department of Bioscience and Bioinformatics Professor
2015/10 - 2019/03 科学技術振興機構さきがけ研究者(兼任)
2012/03 - 2018/05 Kyushu university Medical Institute of Bioregulation Associate Professor
2008/01 - 2012/02 キュリー研究所バイオインフォマティクスユニット常勤研究員(Principal Investigator)

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Committee career (14)：

2024/02 - 現在 Artificial Intelligence in the Life Sciences Editorial Board
2024/01 - 現在 International Society for Computational Biology (ISCB) Board of Directors
2023/04 - 現在日本バイオインフォマティクス学会会長
2018 - 現在日本メディカルAI学会評議員
2018 - 現在日本バイオインフォマティクス学会幹事

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Awards (3)：

2021/07 - 日本毒性学会「田邊賞」
2014/04 - 文部科学大臣表彰「若手科学者賞」
2003/12 - 京都大学化学研究所「所長賞」奨励賞

Association Membership(s) (7)：

THE JAPANESE SOCIETY OF TOXICOLOGY , International Society for Computational Biology (ISCB) , 日本メディカルAI学会 , JAPANESE SOCIETY OF COMPUTATIONAL STATISTICS , The Chem-Bio Informatics Society , JAPANESE SOCIETY FOR BIOINFORMATICS , Division of Chemoinformatics, The Chemical Society of Japan

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