Rchr
J-GLOBAL ID：201601012799704104
Update date: Apr. 13, 2024
Sugita Kazuyuki
スギタ カズユキ | Sugita Kazuyuki
Affiliation and department：
Homepage URL (1)：
https://kaken.nii.ac.jp/d/r/60542090.ja.html
Research field (1)：
Pharmaceuticals - chemistry and drug development
Research keywords (5)：
天然物全合成
, タンパク質間相互作用
, 構造活性相関
, ドラッグデザイン
, 生理活性物質
Research theme for competitive and other funds (14)：
- 2024 - 2029 タンパク質間相互作用調節機能が期待される多環性天然物の効率的合成経路の開発
- 2019 - 2022 Developments of synthetic pathways and syntheses of natural products applicable to a new biological activity evaluation research
- 2016 - 2019 Synthetic study of bioactive molecules aimed at providing natural products and developing into medicinal chemistry
- 2013 - 2018 Reverse proteomics of post-translational modifications utilizing small molecules
- 2014 - 2017 Polypharmacology based on dynamism of the target protein
- 2013 - 2015 Chemical biology of trafficking regulation of membrane cholesterol transporter protein
- 2013 - 2015 Polypharmacological approach to hepatitis C
- 2013 - 2015 Development of radical reaction using bromoalkynes and synthesis of natural products
- 2012 - 2015 Design, synthesis and functional studies of small molecules that modulate protein-protein interactions
- 2012 - 2014 A Theoretical Study of p-Deficient System Aromatic Nucleophlic Substitution (SNAr)
- 2010 - 2014 Chemical control of protein dramatype
- 2010 - 2012 Screening of inhibitors of influenza A virus PA endonuclease
- 2009 - 2012 Multi-functionality and structure development of thalidomide
- 2009 - 2010 Discovery of inhibitors for nuclear receptor functions with multiple mechanisms
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Papers (58)：
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Noriyasu Haginoya, Masanori Suzuki, Makoto Suzuki, Yutaka Ishigai, Koji Terayama, Akira Kanda, Kazuyuki Sugita. Discovery of Novel 11-Membered Templates as Squalene Synthase Inhibitors. Journal of Medicinal Chemistry. 2024
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Naoki Kokaji, Naru Ishikura, Akinobu Matsuzawa, Shogo Kamo, Kazuyuki Sugita. Total synthesis of 14-membered ring β-resorcylic acid lactone (+)-monocillin II. Organic & Biomolecular Chemistry. 2024. 22. 10. 2056-2058
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Tomoya Mashiko, Yuta Shingai, Jun Sakai, Shinya Adachi, Akinobu Matsuzawa, Shogo Kamo, Kazuyuki Sugita. Enantioselective Total Syntheses of (+)-Ganocin A and (-)-Cochlearol B. Organic Letters. 2023. 25. 8382-8386
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Shogo Kamo, Akihiko Kasamatsu, Junya Shiraiwa, Akinobu Matsuzawa, Kazuyuki Sugita. Protecting-Group-Free Total Synthesis of (-)-Boscartin A in 3 steps from (-)-Boscartin F via Wharton Reaction. European Journal of Organic Chemistry. 2022. e202201366
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Eiji Nagata, Hisaaki Sakate, Takaharu Okada, Shinya Adachi, Shogo Kamo, Akinobu Matsuzawa, Kazuyuki Sugita. Synthesis of (±)-5-epi-Vetiverianine A via an Oxidative Cyclization Approach. Synthesis. 2022. 55. 04. 663-669
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MISC (51)：
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M. Kuwabara, A. Matsuo, S. Kamo, A. Matsuzawa, K. Sugita. Stereoselective Synthesis of the Cotylenin A Aglycone Carbon Skeleton. Thieme Chemistry News-Archive 2021. 2021
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R. Matsuo, A. Miyashita, M. Kuwabara, S. Adachi, A. Matsuzawa, K. Sugita. Concise Diastereoselective Total Synthesis of (±)-Parvistemonine A. Thieme Chemistry News-Archive 2020. 2020. 31. 18. 1800-1804
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杉田和幸. キノロン系合成抗菌薬 -研究者の手で創り上げられた抗菌薬のゴールドスタンダード-. 化学と教育. 2019. 67. 11. 113-114
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杉田和幸. Books 紹介、生体有機化学. 日本薬学会医薬品化学部会 MEDCHEMNEWS. 2016. 26. 2. 102-102
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梅田 香織, 遠藤, 安田 佳織, 杉田 和幸, 本多 彰, 太田 美穂, 石川 稔, 橋本 祐一, 榊 利之, 槇島 誠. ステロール代謝酵素CYP27A1による7-デヒドロコレステロール代謝産物の同定及び核内受容体LXRの転写活性化能に対する影響. 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集. 2015. 88回・38回. [1P0184]-[1P0184]
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Patents (22)：
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Preparation of morpholinopurine compounds for inhibiting PI3K and/or mTOR
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Preparation of phenanthridin-6(5H)-one compounds as therapeutic agents for hepatitis C
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Preparation of tricyclic heteroaryl compounds as squalene synthase inhibitors
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Preparation of tricyclic aryl compounds as squalene synthase inhibitors
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Preparation of tricyclic heteroaryl compounds as squalene synthase inhibitors
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Books (4)：
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薬学有機化学・下
京都廣川 2018
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薬学有機化学・上
京都廣川 2018
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メディシナルケミストリー用語解説310
じほう 2014
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生体有機化学
東京化学同人 2012
Lectures and oral presentations (92)：
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Total Syntheses of (-)-Oregonensin A and Related Natural Products
(IKCOC-15 (The International Kyoto Conference on New Aspects of Organic Chemistry) 2023)
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Enantioselective, Protecting-Group-Free Total Syntheses of Boscartins
(IKCOC-15 (The International Kyoto Conference on New Aspects of Organic Chemistry) 2023)
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Enantioselective Total Syntheses of (-)-Cochlearol B and (+)-Ganocin A
(IKCOC-15 (The International Kyoto Conference on New Aspects of Organic Chemistry) 2023)
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(+)-Ganocin Aの全合成
(第49回反応と合成の進歩シンポジウム 2023)
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保護基を用いないboscartin A及びHの不斉全合成
(第67回日本薬学会 関東支部大会 2023)
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Education (2)：
- 1985 - 1987 The University of Tokyo Faculty of Pharmaceutical Sciences
- 1983 - 1985 The University of Tokyo
Professional career (1)：
Work history (5)：
- 2012 - 現在 Hoshi University Hoshi University
- 2009 - 2012 The University of Tokyo Institute of Molecular and Cellular Biosciences
- 1987 - 2009 第一三共株式会社 化学研究所 主任研究員
- 2000 - 2001 米国スクリプス研究所 K.C.Nicolaou研究室 博士研究員
- 1992 - 1994 The University of Tokyo Faculty of Pharmaceutical Sciences
Committee career (5)：
- 2023/04 - 現在 日本薬学会化学系薬学部会 役員
- 2013/02 - 現在 公益社団法人日本薬学会 代議員
- 2013/02 - 2023/03 日本薬学会関東支部 幹事
- 2018/04 - 2021/03 日本薬学会 学術誌編集委員会
- 2012/10 - 2015/03 日本薬学会医薬品化学部会 MEDCHEMNEWS編集委員
Awards (1)：
- 2013/11 - 日本薬学会医薬品化学部会 日本薬学会医薬品化学部会MCS優秀賞 スクアレン合成酵素阻害薬DF-461の創製
Association Membership(s) (2)：
THE SOCIETY OF SYNTHETIC ORGANIC CHEMISTRY, JAPAN
, THE PHARMACEUTICAL SOCIETY OF JAPAN
