Nishiyama Nobuhiro

ニシヤマノブヒロ | Nishiyama Nobuhiro

Affiliation and department：
Job title： Professor
Other affiliations (1)：

KAWASAKI INSTITUTE OF INDUSTRIAL PROMOTION, Innovation Center of NanoMedicine Nishiyama Laboratory Principal Investigator

Research field (1)： Biomaterials

Research keywords (3)： Nanomedicine , Drug Delivery System , Biomaterials Science

Research theme for competitive and other funds (34)：

2022 - 2026 Development of polymeric micelles based on innovative core-shell design for various therapeutic modalities
2021 - 2024 A New Photodynamic Therapy System for Deep Organ Cancer Using an Implantable Light-Emitting Device
2018 - 2022 Development of smart polymeric micelles based on novel shell and core designs
2017 - 2020 Highly efficient cancer treatment system combined with a drug-delivery photoabsorbent agent and a tempreature-controled laser system
2016 - 2019 診断分子と治療分子を搭載したセラノスティック型ナノDDSの創製

2016 - 2019 深部がんのイメージングおよび標的治療を可能にする高分子ナノデバイスの創製

2016 - 2018 Development of innovative nucleic acid medicine for gastroenterological cancer

2016 - 2018 Design of functional polymers responsive to tumor microenvironment and their applications for diagnosis and therapy

2015 - 2018 Design of functional ligand molecules focused on specific metabolism of cancer cells and their applications for diagnosis and therapy

2015 - 2017 New construction of in vivo reprogramming technology by modified microRNA

2014 - 2017 New construction of innovative drug discovery foundation technology for refractory gastrointestinal cancer targeting cancer metabolomics

2013 - 2017 Development of Polymeric Micelles for Brain-Targeted Delivery of Nucleic Acid Drugs to Treat Intractable Neurological Diseases

2013 - 2015 Development of smart MRI contrast agents based on polymeric micelles to detect tumor microenvironment

2013 - 2015 固形がんの特異的イメージングのためのMRI造影剤搭載ナノデバイスの研究開発

2012 - 2015 Development of efficient drug and gene delivery system for malignant brain tumors using polymeric nanomicelles.

2011 - 2015 Development of systemically injectable siRNA delivery systems by fine-tuning of block copolymers

2011 - 2014 Theranostic system for cancer by the combination of supramolecular nanocarriers with optical technology

2012 - 2013 環境応答性と標的指向性を兼備した機能性DDSの開発

2009 - 2011 Development of Novel Therapeutic Angiogenesis Method by Combination of Nanotechnology and siRNA Targeting PHD2

2009 - 2011 Development of selective and efficient drug delivery system for malignant brain tumors using polymeric nanomicelles.

2009 - 2011 Multidiciplinary TNF・a based gene therapy using polyplex micelle

2009 - 2010 生体内環境耐性と応答性を兼備したリピド被覆型高分子ミセルドラッグ

2008 - 2010 Novel approach for management of age-related macular degeneration using nanotechnology

2008 - 2010 Development of multifunctional polymeric micelles for systemic siRNA delivery

2007 - 2009 Innovative nano-therapy based on nanocarriers equipped with the ability to circumvent biological barriers

2007 - 2009 Strategic development of a novel implant system to achieve bone regeneration without cell transplantation

2005 - 2009 Polymeric micelle nanocarrier for drug and gene delivery

2006 - 2007 Novel Approach for Brain Tumor Treatment using Nano-micelle Drug Delivery System

2005 - 2007 Development of functional polymeirc micelles responding to intracellular microenvironments for cancer chemotherapy

2005 - 2006 Development of application of compact tunable monochromatic X-ray source

2004 - 2006 部位選択的な遺伝子治療のための光を利用した新規ナノ医療システムの創製

2004 - 2005 Nano-micelle Drug Delivery System for the Treatment of Brain Tumors

2004 - 2005 Novel tissue regeneration using polymer nano-micelle gene delivery system

2003 - 2005 New support system of vascular surgery using novel bio-materials

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Papers (386)：

Wanphiwat Chintrakulchai, Aziz Awaad, Motoaki Kobayashi, Koki Yanagida, Camille Lindley Tiu, Masahiro Toyoda, Kyohei Muguruma, Yuto Honda, Hiroyasu Takemoto, Nobuhiro Nishiyama, et al. Polyzwitterion-Based pH-Responsive Shell of Polymeric Micelle: Evaluation of Physicochemical Properties and In Vivo Functionalities. Biomacromolecules. 2025
Kakeru Konarita, Minoru Suzuki, Daiki Tokura, Megumi Sunahara, Aya Sudani, Yuko Ishino, Hideki Nakashima, Toshimitsu Hayashi, Koki Uehara, Nobuhiro Nishiyama, et al. Poly(vinyl alcohol) enhancing therapeutic effects of 4-l-boronophenylalanine on thoracic tumors in neutron capture therapy. International journal of pharmaceutics. 2025. 682. 125955-125955
Yuto Honda, Haruna Haraguchi, Takeru Tsuda, Rui Ko, Kyohei Muguruma, Haochen Guo, Takahiro Nomoto, Yutaka Miura, Nobuhiro Nishiyama. Metal-phenolic network-based polymeric nanocarriers facilitating antibody cytoplasmic delivery and anti-tumor effects to orthotopic breast tumors. Journal of controlled release : official journal of the Controlled Release Society. 2025. 384. 113929-113929
Yan Ming Voon, Haochen Guo, Kaito Kanamori, Tomoko Ogiyama, Hiroyuki Chaya, Koji Morita, Nobuhiro Nishiyama, Takahiro Nomoto. Effect of Spacers on the Affinity of Tyrosine-Modified Polymers to L-Type Amino Acid Transporter 1. Biomacromolecules. 2025
Yuki Mochida, Horacio Cabral, Yutaka Miura, Kensuke Osada, Nobuhiro Nishiyama, Kazunori Kataoka. Secondary Structure-Guided Assembly of Uniform Disk-Like Polymeric Micelles Incorporating Hydrophobic Platinum Drugs for Improved Tumor Targeting. Chemistry of Materials. 2025

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MISC (208)：

小成田翔, 小成田翔, 小成田翔, 登倉大貴, 登倉大貴, 登倉大貴, 鈴木実, 西山伸宏, 西山伸宏, 西山伸宏, et al. Poly(vinyl alcohol) improves therapeutic effectiveness of D-amino acid-based boron drug for neutron capture therapy. 日本薬学会年会要旨集(Web). 2024. 144th
本田雄士, 本田雄士, 本田雄士, 松尾拓海, 松尾拓海, 野本貴大, 野本貴大, 西山伸宏, 西山伸宏, 西山伸宏. Systemic applicable Cas9-sgRNP RNP delivery systems based on polymeric ternary complexes for Cancer therapy. 日本薬学会年会要旨集(Web). 2024. 144th
登倉大貴, 登倉大貴, 登倉大貴, 小成田翔, 小成田翔, 小成田翔, 鈴木実, 西山伸宏, 西山伸宏, 西山伸宏, et al. Development of drug delivery systems permitting active control of pharmacokinetics for boron neutron capture therapy. 日本薬学会年会要旨集(Web). 2024. 144th
本田雄士, 本田雄士, 松尾拓海, 松尾拓海, 野本貴大, 野本貴大, 刑部祐里子, 西山伸宏, 西山伸宏. Systemic applicable Cas9-sgRNP RNP delivery systems based on polymeric ternary complexes. 日本ゲノム編集学会大会要旨集. 2023. 8th
本田雄士, 野本貴大, 西山伸宏. Sequential Self-assembly Bio-building Blocks Based on Polyphenol Materials for Efficient Biomolecule Delivery. バイオマテリアル(Web). 2023. 41. 1

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Work history (9)：

2024/10 - 現在 Institute of Science Tokyo Institute of Integrated Research, Laboratory for Chemistry and Life Science Professor
2015/04 - 現在 KAWASAKI INSTITUTE OF INDUSTRIAL PROMOTION, Innovation Center of NanoMedicine Nishiyama Laboratory Principal Investigator
2015/04 - 2024/09 Tokyo Institute of Technology
2013/01 - 2015/03 Tokyo Institute of Technology
2009/09 - 2013/12 The University of Tokyo

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Awards (7)：

2024 - 日本DDS学会第2回日本DDS学会賞
2023 - 東京理科大学第5回東京理科大学物理学園賞
2019 - 文部科学省科学技術分野の文部科学大臣表彰科学技術賞(研究)
2016 - 一般財団法人新製剤技術とエンジニアリング振興基金第3回パーティクルデザイン賞
2012 - 日本癌学会奨励賞

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Association Membership(s) (5)：

日本分子イメージング学会 , 日本バイオマテリアル学会 , 高分子学会 , 日本癌学会 , 日本DDS学会

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