Rchr
J-GLOBAL ID：201601013542228014   Update date: Jul. 14, 2024

Konishi Hiroyuki

コニシ ヒロユキ | Konishi Hiroyuki
Affiliation and department：
Aichi Medical University Department of Biochemistry, School of Medicine

About Aichi Medical University Department of Biochemistry, School of Medicine


Job title： Professor
Research field  (4)： Genomics ,  Systems genomics ,  Medical biochemistry ,  Pathobiochemistry
Research keywords  (6)： genome editing ,  CRISPR-Cas9 ,  gene targeting ,  adeno-associated vector ,  AAV-targeting vector ,  cancer
Research theme for competitive and other funds  (29)：
  • 2022 - 2023 正確で安全性の高い新規ゲノム編集法による疾患遺伝子修復 - 先天性疾患の根治療法へ向けて
  • 2021 - 2023 医療応用を指向する安全で高精度な新規ゲノム編集法tandem paired nicking法の開発研究
  • 2020 - 2023 臨床応用を目指す高効率・高精度なCRISPRノックイン法の確立
  • 2020 - 2021 臨床応用を指向するCRISPR/Cas9ゲノム編集技術の研究
  • 2017 - 2020 CRISPR-Cas9 nickaseによるDNA二重鎖切断を伴わないゲノム編集
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Papers (74)：
  • Sivasundaram Karnan, Ichiro Hanamura, Akinobu Ota, Lam Quang Vu, Kaori Uchino, Tomohiro Horio, Satsuki Murakami, Shohei Mizuno, Md Lutfur Rahman, Md Wahiduzzaman, et al. ARK5 enhances cell survival associated with mitochondrial morphological dynamics from fusion to fission in human multiple myeloma cells. Cell death discovery. 2024. 10. 1. 56-56
  • Muhammad Nazmul Hasan, Toshinori Hyodo, Mrityunjoy Biswas, Md Lutfur Rahman, Yuko Mihara, Sivasundaram Karnan, Akinobu Ota, Shinobu Tsuzuki, Yoshitaka Hosokawa, Hiroyuki Konishi. Flow cytometry-based quantification of genome editing efficiency in human cell lines using the L1CAM gene. PLoS ONE. 2023. 18. 11. e0294146
  • Toshinori Hyodo, Eri Asano-Inami, Satoko Ito, Mai Sugiyama, Akihiro Nawa, Md. Lutfur Rahman, Muhammad Nazmul Hasan, Yuko Mihara, Vu Quang Lam, Sivasundaram Karnan, Akinobu Ota, Shinobu Tsuzuki, Michinari Hamaguchi, Yoshitaka Hosokawa, Hiroyuki Konishi. Leucine zipper protein 1 (LUZP1) regulates the constriction velocity of the contractile ring during cytokinesis. The FEBS Journal. 2023. (in press)
  • Karnan, S., Ota, A., Murakami, H., Rahman, M.L., Wahiduzzaman, M., Hasan, M.N., Vu, L.Q., Hanamura, I., Inoko, A., Riku, M., et al. CAMK2D: a novel molecular target for BAP1-deficient malignant mesothelioma. Cell Death Discovery. 2023. 9. 1
  • Mikako Kato, Akinobu Ota, Takayuki Ono, Sivasundaram Karnan, Toshinori Hyodo, Md Lutfur Rahman, Muhammad Nazmul Hasan, Maho Onda, Sayuri Kondo, Kunihiro Ito, et al. PDZ-binding kinase inhibitor OTS514 suppresses the proliferation of oral squamous carcinoma cells. Oral diseases. 2023
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MISC (52)：
  • 太田明伸, 太田明伸, カルナン シバスンダラン, 小西裕之, 都築忍, 細川好孝, 風岡宜暁. OTS514 suppresses the tumor growth with concomitant downregulation of E2F target genes in oral squamous carcinoma cells. 日本癌学会学術総会抄録集(Web). 2023. 82nd
  • シバスンダラン・カルナン, 太田 明伸, 村上 秀樹, 花村 一朗, 兵頭 寿典, 小西 裕之, 都築 忍, 細川 好孝. 悪性胸膜中皮腫の診断および治療標的新規候補CD24の機能解析. 日本癌学会総会記事. 2020. 79回. PJ4-8
  • Sivasundaram Karnan, 太田 明伸, 兵頭 寿典, 小西 裕之, 都築 忍, 細川 好孝. CRISPR/Cas9を用いたNF2及びCDKN2Aノックアウトヒト中皮腫細胞株の樹立と分子生物学的解析. 日本生化学会大会プログラム・講演要旨集. 2019. 92回. [3P-277]
  • シバスンダラン・カルナン, 太田 明伸, 花村 一朗, 村上 秀樹, 兵頭 寿典, 小西 裕之, 都築 忍, 細川 好孝. p16/NF2遺伝子の欠損により発現の誘導される悪性中皮腫特異的分子の同定(Establishment and characterization of human mesothelial cell lines with CRISPR/Cas9-mediated disruption of NF2 and p16). 日本癌学会総会記事. 2019. 78回. P-1221
  • Sivasundaram Karnan, 太田 明伸, 兵頭 寿典, 小西 裕之, 都築 忍, 細川 好孝. CRISPR/Cas9を用いたNF2及びCDKN2Aノックアウトヒト中皮腫細胞株の樹立と分子生物学的解析. 日本生化学会大会プログラム・講演要旨集. 2019. 92回. [3P-277]
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Books (4)：
  • ゲノム編集の最新技術と医薬品・遺伝子治療・農業・水畜産物・有用物質生産への活用
    技術情報協会 2023 ISBN:9784861049781
  • ゲノム編集技術~各分野への応用/操作上のポイント/各国規制
    情報機構 2022 ISBN:9784865022421
  • ゲノム編集技術を応用した製品開発とその実用化
    技術情報協会 2021 ISBN:9784861048272
  • 臨床腫瘍学 = Clinical oncology
    癌と化学療法社 2003 ISBN:490622539X
Lectures and oral presentations  (6)：
  • Tandem paired nicking using Cas9 nickases permits targeted knock-in without significant inhibition by p53
    (Frontiers in Genome Engineering 2019)
  • Single-nucleotide polymorphism in the PBK gene is closely associated with myeloma cell proliferation
    (The 22nd Congress of the European Hematology Association 2017)
  • A new protocol of somatic cell gene targeting in human cell lines and its application to breast cancer research
    (The 15th Japan-Korea Cancer Research Workshop 2010)
  • The MMSET gene contributes to the growth, adhesion, and tumorigenicity of t(4;14) multiple myeloma cells
    (American Society of Hematology 49th annual meeting 2007)
  • Creation of new cell models for ras-induced oncogenesis by targeted knock-in of mutant K-ras gene in immortalized human breast epithelial cells
    (American Association for Cancer Research 98th annual meeting 2007)
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Education (3)：
  • 愛知県がんセンター研究所 分子腫瘍学部(任意研修生)
  • Osaka University School of Medicine
  • Osaka University Graduate School of Medicine
Professional career (2)：
  • M.D. (Osaka University)
  • Ph.D. (Osaka University)
Work history (7)：
  • 2013/04 - 現在 Aichi Medical University Department of Biochemistry, School of Medicine Professor
  • 2009/04 - 2013/03 Aichi Medical University Department of Biochemistry, School of Medicine Associate Professor
  • 2007/10 - 2009/03 ジョンズホプキンス大学 医学部腫瘍学科 リサーチアソシエイト
  • 2003/09 - 2007/09 ジョンズホプキンス大学 医学部腫瘍学科 博士研究員
  • 2001/07 - 2003/08 愛知県がんセンター研究所 分子腫瘍学部 主任研究員
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Awards (2)：
  • 2006/07 - FAMRI, USA ($243,750; ~3/31/2009) Young Clinical Scientist Award
  • 2003/07 - American Association for Cancer Research Scholar-in-Training Award Identification and detailed characterization of a homozygous deletion at 17p13.3 in human lung cancer, which involves 14-3-3ε and a novel gene, LOST1
Association Membership(s) (3)：
THE JAPANESE CANCER ASSOCIATION ,  THE JAPANESE SOCIETY FOR GENOME EDITING ,  THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
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