Research theme for competitive and other funds (4)：
2018 - 2021 Roles of methionine enkephalin produced by osteocytes in mechanical stress-induced bone metabolism
2017 - 2020 Induction of differentiation of dental mesenchymal cells from human iPS cells
2017 - 2020 Establishment of a novel method for including iPS cell-derived odontogenic epithelial cells based on the elucidation of the role of Hif1a
2015 - 2017 Development of method for generation of iPS cell-derived odontogenic cells by gene transfection
Papers (11)：
S Kimura, N Takeshita, T Oyanagi, D Seki, W Jiang, K Hidaka, S Fukumoto, I Takahashi, T Takano-Yamamoto. HIF-2α Inhibits Ameloblast Differentiation via Hey2 in Tooth Development. Journal of dental research. 2022. 101. 13. 1637-1644
Ikuko Takano, Nobuo Takeshita, Michiko Yoshida, Daisuke Seki, Toshihito Oyanagi, Seiji Kimura, Wei Jiang, Kiyo Sasaki, Chisumi Sogi, Masayoshi Kawatsu, et al. Ten-m/Odz3 regulates migration and differentiation of chondrogenic ATDC5 cells via RhoA-mediated actin reorganization. Journal of cellular physiology. 2021. 236. 4. 2906-2919
Chisumi Sogi, Nobuo Takeshita, Wei Jiang, Siyoung Kim, Toshihiro Maeda, Michiko Yoshida, Toshihito Oyanagi, Arata Ito, Seiji Kimura, Daisuke Seki, et al. Methionine Enkephalin Suppresses Osteocyte Apoptosis Induced by Compressive Force through Regulation of Nuclear Translocation of NFATc1. JBMR Plus. 2020. 4. 7
Oyanagi T, Takeshita N, Hara M, Ikeda E, Chida T, Seki D, Yoshida M, Seiryu M, Takano I, Kimura S, et al. Insulin-like growth factor 1 modulates bioengineered tooth morphogenesis. Scientific reports. 2019. 9. 1. 368
Differentiation of Odontoblast-Like Cells from Mouse Induced Pluripotent Stem Cells by Pax9 and Bmp4 Transfection.
(The 10th Anniversary International Workshop on Biomaterials in Interface Science, Innovative Research for Biosis-Abiosis Intelligent Interface Summer Seminar 2015 2015)
Education (2)：
2011 - 2015 東北大学大学院 歯学研究科
2004 - 2010 Tohoku University Faculty of Dentistry
Professional career (1)：
歯学博士 (東北大学)
Work history (4)：
2019/04 - 現在 Tohoku University Graduate School of Dentistry
2018/09 - 2019/03 東北大学病院 矯正歯科 助教
2015/09 - 2018/08 Tohoku University Graduate School of Dentistry
