Rchr
J-GLOBAL ID：201601015251909327   Update date: Aug. 31, 2024

MOTOMI OSATO

オオサト モトミ | MOTOMI OSATO
Affiliation and department：
Kumamoto University International Research Center for Medical Sciences

About Kumamoto University International Research Center for Medical Sciences


Homepage URL  (1)： http://ircms.kumamoto-u.ac.jp/research/motomi_osato/
Research field  (2)： Hematology and oncology ,  Tumor biology
Research keywords  (14)： LINE-1 ,  phase separation ,  telomere ,  Down's syndrome ,  Aging ,  Animal model ,  Retroelements ,  Non-coding genome ,  Hematology ,  Runx ,  Transcription factor ,  Enhancer ,  Hematopoietic stem cell ,  Leukemia
Research theme for competitive and other funds  (8)：
  • 2023 - 2026 新たな膵再生医療の構築に向けたeR1活性細胞の幹細胞機能の解析
  • 2022 - 2025 Elucidation of the molecular basis for age-dependent leukemogenesis towards a novel therapeutic strategy
  • 2019 - 2022 Development of novel antibodies against leukemia and elucidation of their blocking mechanisms
  • 2018 - 2021 multi-pathogenesis aging research based on the Down syndrome aneuploidy model
  • 2017 - 2020 15-PGDH regulates leukemia stem cell potential in HOX-associated myeloid leukemia
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Papers (153)：
  • Akiko Niibori-Nambu, Chelsia Qiuxia Wang, Desmond Wai Loon Chin, Jing Yuan Chooi, Hiroki Hosoi, Takashi Sonoki, Cheng-Yong Tham, Giselle Sek Suan Nah, Branko Cirovic, Darren Qiancheng Tan, et al. Integrin-α9 overexpression underlies the niche-independent maintenance of leukemia stem cells in acute myeloid leukemia. Gene. 2024. 928. 148761-148761
  • Kelly Ooi Kee Ong, Michelle Meng Huang Mok, Akiko Niibori-Nambu, Linsen Du, Masatoshi Yanagida, Chelsia Qiuxia Wang, Avinash Govind Bahirvani, Desmond Wai Loon Chin, Cai Ping Koh, King Pan Ng, et al. Activation of NOTCH signaling impedes cell proliferation and survival in acute megakaryoblastic leukemia. Experimental hematology. 2024. 137. 104255-104255
  • Sho Kubota, Yuqi Sun, Mariko Morii, Jie Bai, Takako Ideue, Mayumi Hirayama, Supannika Sorin, Eerdunduleng, Takako Yokomizo-Nakano, Motomi Osato, et al. Chromatin modifier Hmga2 promotes adult hematopoietic stem cell function and blood regeneration in stress conditions. The EMBO journal. 2024
  • Keiko Yano-Sakamoto, Yuichiro Kitai, Naoya Toriu, Shinya Yamamoto, Ken Mizuta, Mitinori Saitou, Tomoyuki Tsukiyama, Ichiro Taniuchi, Motomi Osato, Motoko Yanagita. Expression pattern of Runt-related transcription factor (RUNX) family members and the role of RUNX1 during kidney development. Biochemical and biophysical research communications. 2024. 722. 150155-150155
  • Hiroki Hosoi, Shotaro Tabata, Hideki Kosako, Yoshikazu Hori, Tadashi Okamura, Yusuke Yamashita, Kota Fujimoto, Daiki Kajioka, Kentaro Suzuki, Motomi Osato, et al. IGLL5 controlled by super-enhancer affects cell survival and MYC expression in mature B-cell lymphoma. Leukemia research reports. 2024. 21. 100451-100451
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MISC (103)：
  • 佐々木 啓迪, 山村 明寛, 岡本 浩二, 添田 敏寛, 川名 友美, 杉沢 徳彦, 土屋 尭裕, 井本 博文, 田中 直樹, 西條 文人, et al. 肝臓におけるeR1活性幹細胞の同定とその役割. 日本外科学会定期学術集会抄録集. 2024. 124回. SF-8
  • 大里 元美, Teoh Vania, 南部 晶子, Abdallah Gaber, 滝澤 仁, 指田 吾郎. HMGA2高発現はt(8;21)転座白血病の若年発症及び予後不良群を規定する. 日本血液学会学術集会. 2023. 85回. 1460-1460
  • 大里 元美. AML1/RUNX1の発見と白血病(1)PEBP2/CBFの発見. BIO Clinica. 2023. 38. 3. 229-233
  • 清水 六花, 田中 美和, 本目 みずき, 粂川 昂平, 山崎 ゆかり, 山下 亨子, 大里 元美, 丸山 玲緒, 中村 卓郎. がんの可塑性・不均一性 HEY1-NCOA2はRunx2との相互作用を介して間葉性軟骨肉腫を発生と悪性化を誘導する(HEY1-NCOA2 expression induces mesenchymal chondrosarcoma interacting with Runx2). 日本癌学会総会記事. 2022. 81回. S6-2
  • 松尾美沙希, 菅田謙治, ISHRAT Jahan, 二宮菜穂, 大里元美, 大里元美, 佐藤賢文. Identification and Molecular Characterization of a Novel HTLV-1 Silencer. 日本分子生物学会年会プログラム・要旨集(Web). 2022. 45th
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Lectures and oral presentations  (19)：
  • 造血幹細胞特異的遺伝子操作を可能とするRunx1 enhancer-CreERT2トランスジェニックマウス(Runx1 enhancer-CreERT2 transgenic mice for hematopoietic stem cells-specific gene targeting, imaging and transgenesis)
    (日本癌学会総会記事 2014)
  • 世界で活躍するがん研究者の視点 Runxファミリー遺伝子と発がん機構(Challenging cancer research from international frontier Runx family genes and tumorigenesis)
    (日本癌学会総会記事 2012)
  • Runx1/AML1不全は造血幹細胞/前駆細胞において発癌性Rasの誘導する細胞老化、アポトーシスおよび分化を抑制する(Runx1/AML1 insufficiency attenuates oncogenic RAS-induced senescence, apoptosis and differentiation in hematopoietic stem/progenitor cells)
    (日本癌学会総会記事 2006)
  • RUNX1/AML1の増量投与は骨髄性白血病の発生を促進する DS-AMKL(ダウン症関連急性巨核芽球性白血病)の意味(An increased dose of RUNX1/AML1 promotes the development of myeloid leukemia: implications for DS-AMKL)
    (日本癌学会総会記事 2004)
  • 家族性白血病FPD/AMLマウスモデル系の作成
    (日本癌学会総会記事 2001)
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Education (2)：
  • 1993 - 1997 Kumamoto Univeristy Graduate School of Medicine
  • 1984 - 1990 Oita Medical University
Professional career (1)：
  • 医学博士 (熊本大学)
Work history (5)：
  • 2015/04 - 現在 Kumamoto University International Research Center for Medical Sciences Professor
  • 2008/10 - 2022/12 National University of Singapore Cancer Science Institute Associate Professor
  • 2002/04 - 2008/09 Institute of Molecular and Cell Biology (Singapore) Assistant Professor
  • 1997/04 - 2002/03 Kyoto University Institute for Virus Research Research Fellow
  • 1990/04 - 1993/03 Kumamoto University Hospital Clinical Fellow
Committee career (2)：
  • 2012 - 2024/08 Gene Associate Editor
  • 2012 - 2024/08 Gene 編集委員
Association Membership(s) (4)：
Molecular Biology Society of Japan ,  AMERICAN SOCIETY OF HEMATOLOGY ,  THE JAPANESE CANCER ASSOCIATION ,  THE JAPANESE SOCIETY OF HEMATOLOGY
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