Research field (2)：
Pharmaceuticals - chemistry and drug development
, Virology
Research keywords (2)：
創薬
, エイズウイルス
Research theme for competitive and other funds (20)：
2023 - 2026 次世代ALS治療薬としてのエダラボン-c-Abl阻害剤ハイブリッドの創製
2022 - 2025 神経線維腫症の神経系細胞異常分化と腫瘍化の責任因子シグナルと治療標的の解明
2022 - 2025 Development of therapeutic drugs that tandemly suppress infection, lung fibrosis, and malignant transformation of the new coronavirus
2024 - 2025 Elucidation of intracellular and extracellular signals involved in abnormal neural differentiation and tumorigenesis in neurofibromatosis and development of therapeutic strategies
2020 - 2023 Structure optimization of compounds to confine HIV in a cell and induce apoptosis aiming at drugs
2017 - 2020 Development of a method to induce apoptosis by HIV locked in a cell
2016 - 2018 Development of a novel brain protectant
2014 - 2017 Physicochemical analysis of metallo-beta-lactamase with improved catalytic efficiency for cephem antibiotics
2014 - 2017 Development of inhibitors based on the molecular structure and mechanism of substrate hydrolysis by metallo-beta-lactamases
2014 - 2016 Design and synthesis of a compound targeting amyloid beta aiming at the cure of Alzheimer's disease
2013 - 2016 Elucidation of SAMHD1-independent function of HIV/SIV Vpx
2011 - 2014 Development of medicinal molecules having biologically functions targeting the PI3K/Akt pathway and the TGF-b/Smad pathway
2010 - 2011 Design and synthesis of anti-HIV agents that inhibit the Vif-mediated proteasome degradation of APOBEC3G
2009 - 2011 Identification and functional analysis of anti-HIV host factor in macrophages
2007 - 2008 Regulation of HIV replication by inositol phosphates
2003 - 2005 Regulation of HIV replication by proteasome degradation of Vif
2002 - 2004 Functional domain analysis of HIV accessory proteins
2002 - 2002 HIV病原性解析のための新規感染実験システムの確立
2002 - 2002 HIV/SIV Gagハイブリッドウイルスの作製とその解析
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Papers (150)：
Tsugumasa Toma, Nobukazu Miyakawa, Yuiichi Arakaki, Takuro Watanabe, Ryosei Nakahara, Taha F S Ali, Tanima Biswas, Mikio Todaka, Tatsuya Kondo, Mikako Fujita, et al. An antifibrotic compound that ameliorates hyperglycaemia and fat accumulation in cell and HFD mouse models. Diabetologia. 2024
Perpetual Nyame, Akihiro Togami, Tomofumi Yoshida, Takuya Masunaga, Mst Monira Begum, Hiromi Terasawa, Nami Monde, Yurika Tahara, Reiko Tanaka, Yuetsu Tanaka, et al. A heterocyclic compound inhibits viral release by inducing cell surface BST2/Tetherin/CD317/HM1.24. The Journal of Biological Chemistry. 2024. 107701-107701
Mohamed O. Radwan, Sawa Sakai, Alaa N. Hassan, Momoko Uesugi, Masaharu Sakamoto, Tsugumasa Toma, Mohammed A.S. Abourehab, Mostafa M. Badran, Hiroshi Tateishi, Nao Nishimura, et al. Discovery of cytotoxic truncated vitamin D derivatives against both bortezomib-sensitive and bortezomib-resistant multiple myeloma phenotypes. Medicinal Chemistry Research. 2024. 33. 5. 829-837
Mostafa M Badran, Samar H Abbas, Hiroshi Tateishi, Yuki Maemoto, Tsugumasa Toma, Akihiro Ito, Mikako Fujita, Masami Otsuka, Mohamed Abdel-Aziz, Mohamed O Radwan. Ligand-based design and synthesis of new trityl histamine and trityl cysteamine derivatives as SIRT2 inhibitors for cancer therapy. European Journal of Medicinal Chemistry. 2024. 269. 116302-116302
Belgin Sever, Masami Otsuka, Mikako Fujita, Halilibrahim Ciftci. A Review of FDA-Approved Anti-HIV-1 Drugs, Anti-Gag Compounds, and Potential Strategies for HIV-1 Eradication. International Journal of Molecular Sciences. 2024. 25. 7
牧野雄成, 當眞嗣雅, 立石大, 藤田美歌子, 大塚雅巳, 大塚雅巳, 片岡良友. Molecular pathology of systemic sclerosis and molecular design of a therapeutic drug. Bio Clinica. 2022. 37. 9
Ali Taha, 岩丸 佳奈, Ciftci Halil, 古賀 涼子, 黒崎 博雅, 藤田 美歌子, 岡本 良成, 秀 拓一郎, 牧野 敬史, 倉津 純一, et al. 抗癌活性を持つ新規の金属キレート分子(Novel metal chelating molecules with anticancer activity). 日本薬学会年会要旨集. 2015. 135年会. 2. 137-137
1981 - 1985 Chiba University Faculty of Science Department of Chemistry
Professional career (1)：
薬学博士 (京都大学)
Work history (5)：
2019/04 - 現在 Kumamoto University
2006/08 - 2019/03 Kumamoto University
1999/10 - 2006/07 The University of Tokushima
1998/04 - 1999/09 Kumamoto University
1988/04 - 1993/03 財団法人 相模中央化学研究所
Committee career (1)：
2018/05 - 現在 日本医療研究開発機構 プログラムオフィサー
Awards (1)：
2012/12 - 日本薬学会九州支部 学術奨励賞
Association Membership(s) (6)：
JAPANESE SOCIETY FOR CHEMICAL BIOLOGY
, THE JAPANESE ASSOCIATION FOR MOLECULAR TARGET THERAPY OF CANCER
, THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
, THE JAPANESE SOCIETY FOR AIDS RESEARCH
, THE JAPANESE SOCIETY FOR VIROLOGY
, THE PHARMACEUTICAL SOCIETY OF JAPAN
