Rchr
J-GLOBAL ID：201601016872044768
Update date: May. 13, 2024
SASHIDA GORO
サシダ ゴロウ | SASHIDA GORO
Affiliation and department：
Job title：
Professor
Homepage URL (1)：
http://ircms.kumamoto-u.ac.jp/research/goro_sashida/
Research field (3)：
Tumor biology
, Hematology and oncology
, Cell biology
Research keywords (7)：
染色体
, クロマチン
, トリソミー
, 転写因子
, 造血幹細胞
, 骨髄異形成症候群
, 急性骨髄性白血病
Research theme for competitive and other funds (15)：
- 2022 - 2025 Elucidation of the molecular basis for age-dependent leukemogenesis towards a novel therapeutic strategy
- 2021 - 2025 マイクロRNA miR-142の機能獲得型変異による白血病発症メカニズムの解明
- 2021 - 2024 ストレス造血における幹細胞エピゲノム制御と細胞運命決定機構の解析
- 2021 - 2024 A Crosstalk Between Inflammation and Epigenetics in Regulating HSC Fitness
- 2021 - 2023 数的染色体異常による造血幹細胞制御とMDS発症機序の解析
- 2019 - 2023 Development of novel antibodies against leukemia and elucidation of their blocking mechanisms
- 2019 - 2021 Understanding of pathogenesis of Trisomy 8-induced myelodysplastic syndrome
- 2018 - 2021 Infection stresses promote the pathogenesis of myelodysplastic syndrome
- 2016 - 2019 Molecular mechanisms in the pathogenesis of myelodysplastic syndrome
- 2015 - 2018 Roles of tyrosine phosphorylation of KAP1 in leukemogenesis
- 2014 - 2017 Epigenetic dysregulation in myelodysplastic syndromes in the absence of Ezh2
- 2012 - 2015 Role of epigenetic dysregulation in the pathogenesis of hematological malignancies
- 2010 - 2015 Clarification of molecular mechanisms regulating lineage commitment taking place on the way from multipotent hematopoietic progenitors to unipotent T cell progenitors
- 2011 - 2013 Molecular mechanism of MLL mutant-induced MDS
- 2003 - 2004 PNAプローブを用いた簡便なテロメア長測定法の開発
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Papers (96)：
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Mariko Morii, Sho Kubota, Mihoko Iimori, Takako Yokomizo-Nakano, Ai Hamashima, Jie Bai, Akiho Nishimura, Masayoshi Tasaki, Yukio Ando, Kimi Araki, et al. TIF1β activates leukemic transcriptional program in HSCs and promotes BCR::ABL1-induced myeloid leukemia. Leukemia. 2024
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Hiroto Ohguchi, Yasuyo Ohguchi, Sho Kubota, Kan Etoh, Ai Hamashima, Shingo Usuki, Takako Yokomizo-Nakano, Jie Bai, Takeshi Masuda, Yawara Kawano, et al. Multiple myeloma-associated DIS3 gene is essential for hematopoiesis but loss of DIS3 is insufficient for myelomagenesis. Blood Neoplasia. 2024. 100005-100005
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Takako Yokomizo-Nakano, Ai Hamashima, Sho Kubota, Jie Bai, Supannika Sorin, Yuqi Sun, Kenta Kikuchi, Mihoko Iimori, Mariko Morii, Akinori Kanai, et al. Exposure to microbial products followed by loss of Tet2 promotes myelodysplastic syndrome via remodeling HSCs. The Journal of experimental medicine. 2023. 220. 7
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Shingo Kawano, Kimi Araki, Jie Bai, Imari Furukawa, Keigo Tateishi, Kumiko Yoshinobu, Shingo Usuki, Rachael A. Nimmo, Tadashi Kaname, Masaharu Yoshihara, et al. A gain-of-function mutation in microRNA 142 is sufficient to cause the development of T-cell leukemia in mice. Cancer Science. 2023
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Takuro Kameda, Kotaro Shide, Ayako Kamiunten, Yasunori Kogure, Daisuke Morishita, Junji Koya, Yuki Tahira, Keiichi Akizuki, Takako Yokomizo-Nakano, Sho Kubota, et al. CARD11 mutation and HBZ expression induce lymphoproliferative disease and adult T-cell leukemia/lymphoma. Communications Biology. 2022. 5. 1. 1309-1309
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MISC (59)：
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青山 和正, 篠田 大輔, 鈴木 瑛美, 中島 やえ子, 大島 基彦, 小出 周平, Ola Rizq, 太良 史郎, 指田 吾郎, 岩間 厚志. PRC2の機能低下は、Cdkn2aの脱抑制を介して骨髄異形成症候群におけるp53依存性赤血球産生異常を誘発する. 日本生化学会大会プログラム・講演要旨集. 2021. 94回. [P-740]
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篠田大輔, 中島やえ子, 大島基彦, 小出周平, 青山和正, 更屋敦則, 原田浩徳, 古関明彦, 下田和哉, 指田吾郎, et al. PRC1.1 insufficiency promotes the development of myelofibrosis. 日本血液学会学術集会抄録(Web). 2021. 83rd
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青山 和正, 鈴木 瑛美, 大島 基彦, 望月 牧子, 尾, 小出 周平, 加藤 裕子, 中島 やえ子, 指田 吾郎, 岩間 厚志. Ezh2欠損造血幹細胞維持におけるEzh1によるエピジェネティック制御. 生命科学系学会合同年次大会. 2017. 2017年度. [3PT18-05(3P
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Y. Hayashi, Y. Zhang, X. Yan, G. Sashida, K. Chetal, A. Olsson, H. Harada, L. Y. Shih, W. Tse, J. Bridges, et al. 6 HIF1A SIGNALING IS A CENTRAL PATHOBIOLOGIC MEDIATOR OF MDS. LEUKEMIA RESEARCH. 2017. 55. S6-S6
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SASHIDA Goro. Epigenetic dysregulation in myelodysplastic syndromes. Rinsho Ketsueki. 2017. 58. 10. 1809-1817
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Lectures and oral presentations (69)：
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PRC2の機能低下は、Cdkn2aの脱抑制を介して骨髄異形成症候群におけるp53依存性赤血球産生異常を誘発する
(日本生化学会大会プログラム・講演要旨集 2021)
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PRC1.1機能不全は骨髄線維症を著明に促進させる(PRC1.1 insufficiency promotes the development of myelofibrosis)
(日本血液学会学術集会 2021)
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感染記憶によるElf1活性化を介した骨髄異形成症候群の発症機構の解析(Inflammatory signaling initiate the transformation of pre-MDS stem cells via activation of Elf1)
(日本血液学会学術集会 2021)
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Tet2欠損によるHmga2機能制御と骨髄異形成症候群発症の分子基盤(Tet2 loss reshapes Hmga2 binding regions to promote the development of myelodysplastic syndrome)
(日本癌学会総会記事 2019)
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Tet2欠損によるHmga2機能制御と骨髄異形成症候群発症の分子基盤(Tet2 loss reshapes Hmga2 binding regions to promote the development of myelodysplastic syndrome)
(日本癌学会総会記事 2019)
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Education (2)：
- 1990 - 1996 Tokyo Medical University
- 1983 - 1989 麻布中学校・高等学校
Professional career (1)：
Work history (7)：
- 2016/12 - 現在 Kumamoto University International Research Center for Medical Sciences Professor
- 2014/12 - 2016/11 Kumamoto University International Research Center for Medical Sciences Associate Professor
- 2014/04 - 2014/11 千葉大学大学院医学研究院 細胞分子医学 講師
- 2010/11 - 2014/03 千葉大学大学院医学研究院 細胞分子医学 助教
- 2009/09 - 2010/10 Cincinnati Children’s Hospital Medical Center Visiting Research Scientist
- 2005/12 - 2009/09 Memorial Sloan-Kettering Cancer Center Research Scholar
- 2002/06 - 2005/11 東京医科大学病院 内科学第一講座 助手
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