2020 - 2023 Development of novel pathological analysis and medicine in neuropathic Gaucher disease.
2018 - 2023 GM1ガングリオシドを標的としたアルツハイマー病の新規治療薬開発
2021 - 2023 新技術と新治療コンセプトに基づく先天代謝異常症に対する治療薬開発
2020 - 2022 先天代謝異常症の新規表現型の解析と薬剤開発の拠点研究
2020 - 2021 PD-1遺伝子改変T細胞を用いた養子細胞移入療法の開発
2016 - 2018 Drug Development for GM1 Gangliosidosis using the patients-derived iPS cells
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Papers (34):
Tadahiro Numakawa, Ryutaro Kajihara. Interplay of BDNF and Glucocorticoids in Alzheimer’s Disease. Encyclopedia. 2024. 54754-54754
Tadahiro Numakawa, Ryutaro Kajihara. An Interaction between Brain-Derived Neurotrophic Factor and Stress-Related Glucocorticoids in the Pathophysiology of Alzheimer’s Disease. International Journal of Molecular Sciences. 2024. 25. 3. 1596-1596
Manali Begur, Takayoshi Yamauchi, Hidehito Saito, Takaaki Oba, Ryutaro Kajihara, Leighton Stein, Mark Hoenerhoff, Fumito Ito. Unraveling Tumorigenicity in iPSC-Derived Immune Cells: The Impact of Chromosomal Abnormalities and Proliferative Intermediates. Blood. 2023. 142. 2081-2081
Fumito Ito, Long D Mark, Ryutaro Kajihara, Takayoshi Yamauchi, Hongbin Chen, Brahm Segal, Grace K Dy. Genomic and Transcriptomic Signatures of Tumor-Infiltrating T-Cell Repertoires in Peripheral Blood During Immunotherapy. Journal of the American College of Surgeons. 2023. 237. 5. S455-S455
Tadahiro Numakawa, Ryutaro Kajihara. Involvement of brain-derived neurotrophic factor signaling in the pathogenesis of stress-related brain diseases. Frontiers in Molecular Neuroscience. 2023. 16. 1247422-1247422
Prophylactic or therapeutic for gm1 gangliosidosis, and composition for preventing or treating gm1 gangliosidosis
PROPHYLACTIC AGENT OR THERAPEUTIC AGENT FOR ALZHEIMER'S DISEASE, SCREENING METHOD THEREFOR, AND COMPOSITION FOR PREVENTING OR TREATING ALZHEIMER'S DISEASE
JAPANESE SOCIETY FOR INHERITED METABOLIC DISEASES
, THE JAPANESE SOCIETY FOR REGENERATIVE MEDICINE
, 日本プロテインホスファターゼ研究会
, THE JAPANESE BIOCHEMICAL SOCIETY
, 日本癌学会
, 日本免疫学会