Shibata Mikihiro

シバタミキヒロ | Shibata Mikihiro

Affiliation and department：
Other affiliations (1)：

Homepage URL (1)： https://bioafminfi.w3.kanazawa-u.ac.jp

Research field (3)： Neuroscience - general , Nanobioscience , Biophysics

Research keywords (1)： Biophysics, atomic force microscopy, high-speed AFM

Research theme for competitive and other funds (19)：

2024 - 2026 Single-molecule dynamics of ionotropic neurotransmitter receptors revealed by high-speed AFM
2024 - 2026 Real-space and real-time visualization of histone tails by single-molecule imaging
2024 - 2025 1分子イメージングによるAMPA 型グルタミン酸受容体のクラスター化機構の解明
2023 - 2024 記憶タンパク質の1分子ナノ動態解析
2021 - 2024 Investigation of molecular insight into genome editing tools by single-molecule imaging

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Papers (71)：

Ayumi Sumino, Takashi Sumikama, Yimeng Zhao, Holger Flechsig, Kenichi Umeda, Noriyuki Kodera, Hiroki Konno, Motoyuki Hattori, Mikihiro Shibata. High-Speed Atomic Force Microscopy Reveals Fluctuations and Dimer Splitting of the N-Terminal Domain of GluA2 Ionotropic Glutamate Receptor-Auxiliary Subunit Complex. ACS Nano. 2024. 18. 36. 25018-25035
Shin Morioka, Takumi Oishi, Suguru Hatazawa, Takahiro Kakuta, Tomoki Ogoshi, Kenichi Umeda, Noriyuki Kodera, Hitoshi Kurumizaka, Mikihiro Shibata. High-Speed Atomic Force Microscopy Reveals the Nucleosome Sliding and DNA Unwrapping/Wrapping Dynamics of Tail-less Nucleosomes. Nano Letters. 2024. 24. 17. 5246-5254
Ayumi Sumino, Takashi Sumikama, Mikihiro Shibata, Katsumasa Irie. Voltage sensors of a Na+ channel dissociate from the pore domain and form inter-channel dimers in the resting state. Nat. Commun. 2023. 14. 7835
Shotaro Tsujioka, Ayumi Sumino, Yutaro Nagasawa, Takashi Sumikama, Holger Flechsig, Leonardo Puppulin, Takuya Tomita, Yudai Baba, Takahiro Kakuta, Tomoki Ogoshi, et al. Imaging single CaMKII holoenzymes at work by high-speed atomic force microscopy. Sci. Adv. 2023. 9. 26. eadh1069
Ayumi Sumino†, Yimeng Zhao†, Daichi Mukai, Takashi Sumikama, Leonardo Puppulin, Motoyuki Hattori, Mikihiro Shibata. Antithetic effects of agonists and antagonists on the structural fluctuations of TRPV1 channel. Proc. Natl. Acad. Sci. USA. 2023. 120. 20. e2301013120

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MISC (9)：

Ayumi Sumino, Takashi Sumikama, Leonardo Puppulin, Mikihiro Shibata, Katsumasa Irie. Dissociation and inter-channel dimerization of voltage-sensor domains (VSD) of voltage-gated Na+ channel in the resting state. The Journal of Physiological Sciences. 2023. 73. 95
SHIHOYA Wataru, INOUE Keiichi, INOUE Keiichi, INOUE Keiichi, SINGH Manish, KONNO Masae, HOSOSHIMA Shoko, YAMASHITA Keitaro, YAMASHITA Keitaro, IKEDA Kento, et al. Structural and Physicochemical Study on Heliorhodopsin. 日本化学会春季年会講演予稿集(CD-ROM). 2020. 100th
上田哲也, 小島慧一, 日野智也, 柴田幹大, 永野真吾, 須藤雄気. スチレンコポリマー中における微生物型ロドプシンの機能・物性解析. 生体膜と薬物の相互作用シンポジウム講演要旨集. 2019. 41st
SHIHOYA Wataru, INOUE Keiichi, INOUE Keiichi, INOUE Keiichi, MANISH Singh, KONNO Masae, HOSOSHIMA Shoko, YAMASHITA Keitaro, IKEDA Kento, HIGUCHI Akimitsu, et al. Structure and biophysical characterization of the heliorhodopsin. 生物物理(Web). 2019. 59. Supplement 1-2
内橋貴之, 古寺哲幸, 柴田幹大, 安藤敏夫. 高速AFMによる生体試料の動態イメージング. バイオイメージング. 2016. 25. 2. 73-73

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Books (7)：

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Lectures and oral presentations (134)：

Phosphorylation-dependent clustering mechanism of CaMKII revealed by high-speed AFM
(Neuroscience 2024 2024)
Single-molecule nanodynamics of AMPA-type glutamate receptors by high-speed atomic force microscopy
(Neuroscience 2024 2024)
Single-molecule dynamics of membrane proteins in lipids with high-speed AFM
(The 6th International Symposium of Structure-based Drug Discovery (ISDD) & 2024 11th Annual Conference of the Korean Society for Structural Biology (KSSB) 2024)
Single-molecule imaging of AMPA-type glutamate receptors by high-speed atomic force microscopy
(IUPAB2024 2024)
Development of nano-endoscopic high-speed atomic force microscopy
(IUPAB2024 2024)

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Education (3)：

2005 - 2007 Nagoya Institute of Technology Department of Materials Science and Engineering Department of Materials Science and Engineering
2003 - 2005 Nagoya Institute of Technology Department of Materials Science and Engineering Department of Materials Science and Engineering
1999 - 2003 Nagoya Institute of Technology Engeering Applied Chemistry

Professional career (1)：

Work history (11)：

2021/03 - 現在 Kanazawa University Nano Life Science Institute Professor
2017/10 - 2021/02 Kanazawa University WPI-NanoLSI Tenure Track Associate Professor
2016/09 - 2017/10 Kanazawa University Institute for Frontier Science Initiative Tenure Track Associate Professor
2016/03 - 2016/08 Kanazawa University Department of Physics Tenure Track Associate Professor
2015/08/01 - 2016/02/29 Kanazawa University Department of Physics Postdoctoral Fellow

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Committee career (1)：

Awards (4)：

Association Membership(s) (4)：

日本顕微鏡学会 , Biophysical Society , The Molecular Biology Society of Japan , The Biophysical Society of Japan

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