Rchr
J-GLOBAL ID：201701002083468177   Update date: Apr. 02, 2024

Watabe Tetsuro

ワタベ テツロウ | Watabe Tetsuro
Affiliation and department：
Tokyo Medical and Dental University Department of Biochemistry, Graduate School of Medical and Dental Sciences

About Tokyo Medical and Dental University Department of Biochemistry, Graduate School of Medical and Dental Sciences


Homepage URL  (1)： http://cellular-biochemistry-tmdu.net/
Research field  (3)： Oral medicine ,  Tumor biology ,  Pathobiochemistry
Research keywords  (5)： BMP ,  TGF-β ,  lymphangiogenesis ,  angiogenesis ,  cancer
Research theme for competitive and other funds  (22)：
  • 2020 - 2023 シングルセル解析による口腔がんの増殖と運動・転移を司るメカニズムの解明
  • 2017 - 2020 Radiosenstizing mechanism by immune modifications: elucidation from tumor cell kinetics
  • 2017 - 2020 Exosomes promoting malignancy and affecting tumor microenvironment, the target for anti-tumor therapy.
  • 2016 - 2019 Cellular dynamics and molecular mechanism on lymphatic network formation in artificial three-dimensional human tissue
  • 2016 - 2019 Molecular mechanisms of the endothelial-to-mesenchymal transition of lymphatic endothelial cells
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Papers (109)：
  • Yukinori Ikeda, Jun-ichi Suehiro, Hiroko Oshima, Sau Yee Kok, Kazuki Takahashi, Hiroyuki Sakurai, Tetsuro Watabe, Masanobu Oshima, Yukiko T. Matsunaga. Tumor-microvessel on-a-chip reveals sequential intravasation cascade of cancer cell clusters. 2024
  • Hiroki Inoue, Taku Kanda, Gakuto Hayashi, Ryota Munenaga, Masayuki Yoshida, Kana Hasegawa, Takuya Miyagawa, Yukiya Kurumada, Jumpei Hasegawa, Tomoyuki Wada, et al. A MAP1B-cortactin-Tks5 axis regulates TNBC invasion and tumorigenesis. The Journal of cell biology. 2024. 223. 3
  • Kazuki Takahashi, Miho Kobayashi, Hisae Katsumata, Shiori Tokizaki, Tatsuhiko Anzai, Yukinori Ikeda, Daniel M. Alcaide, Kentaro Maeda, Makoto Ishihara, Katsutoshi Tahara, et al. CD40 is expressed in the subsets of endothelial cells undergoing partial endothelial-mesenchymal transition in tumor microenvironment. Cancer Science. 2023
  • Shiori Tokizaki, Katarzyna A. Podyma-Inoue, Takehisa Matsumoto, Kazuki Takahashi, Miho Kobayashi, Haruka Ibi, Shizuka Uchida, Sadahiro Iwabuchi, Hiroyuki Harada, Shinichi Hashimoto, et al. Inhibition of transforming growth factor-β signals suppresses tumor formation by regulation of tumor microenvironment networks. Cancer Science. 2023
  • 小林 美穂, 高橋 和樹, 藤原 花汐, 吉岡 祐亮, 落合 孝広, 井上 カタジナアンナ, 渡部 徹郎. 脈管と周囲組織とを結ぶ多彩な生命科学 口腔がん細胞が放出する細胞外小胞を介した血管不安定化の分子機構. 日本生化学会大会プログラム・講演要旨集. 2023. 96回. [3S09e-04]
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MISC (14)：
  • 高橋和樹, 高橋和樹, 勝又寿枝, 小林美穂, 前田健太郎, 吉松康裕, 吉松康裕, 松永行子, 渡部徹郎, 渡部徹郎. 内皮間葉移行(EndoMT)レポーター内皮細胞を用いたEndoMT遷移段階の可視化. リンパ学. 2023. 46. Supplement
  • 小林美穂, 藤原花汐, 高橋和樹, 高橋和樹, 吉岡祐亮, 落谷孝広, 井上カタジナアンナ, 渡部徹郎. Endothelial destabilization by tumor-derived exosome. リンパ学. 2023. 46. 1
  • 高橋和樹, 勝又寿枝, 小林美穂, 時崎詩織, 時崎詩織, 池田行徳, 前田健太郎, 井上カタジナアンナ, 松永行子, 吉松康裕, et al. Endothelial mesenchymal transition (EndoMT) reporter cells visualized stepwise transition of TGF-β-induced EndoMT. 日本癌学会学術総会抄録集(Web). 2023. 82nd
  • 時崎詩織, 時崎詩織, 井上カタジナアンナ, 高橋和樹, 原田浩之, 渡部徹郎. Development of novel Fc chimeric receptor targeting all TGF-β isoforms. リンパ学. 2022. 45. Supplement
  • 高橋和樹, 高橋和樹, 勝又寿枝, 小林美穂, 池田行徳, 篠原満利恵, 前田健太郎, 吉松康裕, 吉松康裕, 松永行子, et al. Visualization of endothelial-mesenchymal transition (EndoMT) and intravasation of cancer cells using EndoMT reporter cells. リンパ学. 2022. 45. Supplement
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Patents (7)：
  • 抗がん剤
  • 抗がん剤
  • 老化抑制剤のスクリーニング方法
  • 老化抑制剤
  • 血管新生因子と結合するキメラタンパク質
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Education (3)：
  • - 1997 カリフォルニア大学アーヴァイン校(UCI) 生物科学系研究科 博士号(Ph.D.)取得
  • - 1990 The University of Tokyo
  • - 1988 The University of Tokyo
Professional career (1)：
  • Ph.D.
Work history (7)：
  • 2021/04 - 現在 Tokyo Medical and Dental University Department of Biochemistry, Graduate School of Medical and Dental Sciences Professor
  • 2015/07 - 2021/03 Tokyo Medical and Dental University Department of Biochemistry, Graduate School of Medical and Dental Sciences Professor
  • 2013/07 - 2015/06 Tokyo University of Pharmacy and Life Sciences School of Life Science
  • 2009/05 - 2013/06 The University of Tokyo Department of Molecular Pathology Associate Professor
  • 2001/03 - 2009/04 The University of Tokyo Department of Molecular Pathology Assistant Professor
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Committee career (4)：
  • 日本血管生物学会 理事・副理事長
  • 日本リンパ学会 常任理事
  • 日本癌学会 評議員
  • 日本生化学会 評議員
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