Kensuke Miyake | Researcher Information

2022 - 2027 Molecular and structural bases enabling self-derived nucleic acid recognition in lysosomes
2022 - 2027 Self-referential immune perception
2021 - 2025 Studying molecular bases of alternative TLR responses
2019 - 2021 Studying innate immune responses to nucleoside stress
2018 - 2021 Novel therapeutic strategies for Sjogren's syndrome targeting Toll-like receptors.

2016 - 2021 Cell and Molecular mechanisms underlying the interaction between the innate immune system and metabolism in lysosomes

2018 - 2020 自然免疫応答と脂質代謝の連携分子基盤の解明

2017 - 2019 Understanding a mechanism controlling endogenous retrovirus by Toll-like receptors

2015 - 2018 The effect of UV irradiation on development of systemic lupus in mouse model

2016 - 2017 リソソームでの核酸認識における核酸代謝系の役割についての研究

2015 - 2016 The role of a transcription factor TFEB in the innate immune system

2013 - 2016 Molecular basis underlying Toll-like receptor logistics

2014 - 2015 Novel regulatory mechanism of TLR7/8 by ssRNA

2009 - 2014 Toll like receptors; their endogenous ligands and mechanism regulating their activities

2009 - 2014 Homeostatic inflammation: Molecular basis and dysregulation

2012 - 2012 The role of innate immunity in Dilated Cardiomyopathy

2009 - 2010 自然免疫におけるDNA応答とRNA応答の間のバランス制御機構の解明

2008 - 2010 Studying mechanisms controlling responsiveness of Toll-like Receptors

2009 - 2009 TOLL様受容体の認識機構と包括的活性制御機構の解明

2008 - 2009 Toll様受容体の様受容体の内因性リガンドへの応答とその調節機構の解明

2008 - 2008 病原体センサと自己成分との相互作用についての研究

2007 - 2008 Toll-like receptorファミリーの包括的活性制御機構の解明

2004 - 2006 Analyses of Toll-like receptors regulating innate antibody response against microbial lipids

2002 - 2005 Roles for MD molecules in endotoxin recognition

2003 - 2004 INF-α productivity and Toll-like receptor 3 gene polymorphism in patients with febrile seizure

2003 - 2004 The role of MD-2 in the pathogen recognition

2001 - 2004 Analysis of pathogen recognition by TLR4 and RP105 and their application to immunothrapy

2001 - 2002 The Function analysis of MD-2 molecule about LPS recognition

2001 - 2002 Tollファミリー分子(TLR)によるLPS認識と獲得免疫発動機構の解明

2000 - 2002 Recognition of Lipopolysaccharide by The Toll Receptor Complex

2001 - 2001 Toll-like Receptorに会合するMDタンパクの遺伝学的解析

2001 - 2001 Tollファミリー分子による病原体認識機構の解明とそれを応用した癌免疫療法の開発

2000 - 2000 Tollファミリー分子による細菌リポ多糖認識機構解明とそのがん免疫療法への応用

2000 - 2000 Tollファミリー分子による,細菌リポ多糖認識および自己糖脂質との識別機構の解明

1999 - 2000 Analysis of RP105, a novel B cell-associated antigen, in autoimmune diseases

1999 - 1999 癌免疫療法を目的としてロイシンリッチリピート分子の基礎的解析

1998 - 1998 B細胞表面分子RP105についての個体レベル、分子レベルでの機能解析:会合分子の遺伝子単離とRP105ノックアウトマウスの作製

1998 - 1998 ロイシンリッチリピートタンパクによる免疫システム制御機構の解析

1997 - 1998 Molecular and Cellular Analysis of a Leucine-rich Repeat Molecule RP105

1997 - 1997 CD40とRPl05経路によるB細胞活性化機構の比較、解析

1996 - 1996 マウスB細胞表面分子RP105のリガンドの検索及びシグナル伝達機構の解析

1996 - 1996 RP105分子を介するマウスB細胞活性化機構の解析

1994 - 1996 B細胞のシグナル伝達

1995 - 1995 マウスB細胞のアポトーシスを阻害し、増殖を誘導する細胞表面抗原の遺伝子の単離

1995 - 1995 MHCクラスII分子変異細胞株を用いた自己抗原処理・提供機構の解析

1994 - 1994 MHCクラスII分子変異細胞株を用いた自己抗原処理・提供機構の解析

1993 - 1993 MHCクラスII分子変異細胞株を用いた自己抗原処理・提供機構の解析

1991 - 1991 未熟B細胞と骨髄ストローマ細胞との細胞接着機構の解析とそのB細胞産生における役割

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Yoshinori Hirano, Umeharu Ohto, Ikuyo Ichi, Ryota Sato, Kensuke Miyake, Toshiyuki Shimizu. Cryo-EM analysis reveals human SID-1 transmembrane family member 1 dynamics underlying lipid hydrolytic activity. Communications biology. 2024. 7. 1. 664-664
Izumi Sasaki, Yuri Fukuda-Ohta, Chihiro Nakai, Naoko Wakaki-Nishiyama, Chizuyo Okamoto, Daisuke Okuzaki, Shuhei Morita, Shiori Kaji, Yuki Furuta, Hiroaki Hemmi, et al. A stress sensor, IRE1α, is required for bacterial-exotoxin-induced interleukin-1β production in tissue-resident macrophages. Cell Reports. 2024. 43. 4. 113981-113981
Kensuke Miyake, Takuma Shibata, Ryutaro Fukui, Yusuke Murakami, Ryota Sato, Ryosuke Hiranuma. Endosomal Toll-Like Receptors as Therapeutic Targets for Autoimmune Diseases. Advances in experimental medicine and biology. 2024. 1444. 97-108
Ryosuke Hiranuma, Ryota Sato, Kiyoshi Yamaguchi, Satoshi Nakamizo, Kenichi Asano, Takuma Shibata, Ryutaro Fukui, Yoichi Furukawa, Kenji Kabashima, Kensuke Miyake. Aberrant monocytopoiesis drives granuloma development in sarcoidosis. International Immunology. 2023
Gang Liu, Tatt Jhong Haw, Malcolm R Starkey, Ashleigh M Philp, Stelios Pavlidis, Christina Nalkurthi, Prema M Nair, Henry M Gomez, Irwan Hanish, Alan Cy Hsu, et al. TLR7 promotes smoke-induced experimental lung damage through the activity of mast cell tryptase. Nature communications. 2023. 14. 1. 7349-7349

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KOBAYASHI Yohei, SHIMIZU Yuri, SATO Ryota, FUKUI Ryutaro, SHIBATA Takuma, MIYAKE Kensuke. CD20 promotes BCR/TLR9 dependent cell proliferation by enhancing TLR9/IgM association. 日本免疫学会総会・学術集会記録(CD-ROM). 2024. 52
SATO Ryota, LIU Kaiwen, SHIBATA Takuma, FUKUI Ryutaro, HOSHINO Katsuaki, KAISHO Tsuneyasu, MIYAKE Kensuke. The role of RNase T2 in macrophage homeostasis. 日本免疫学会総会・学術集会記録(CD-ROM). 2022. 51
HIRANUMA Ryosuke, SATO Ryota, MIYAKE Kensuke. Molecular mechanisms by which mTORC1 drives granulomas. 日本インターフェロン・サイトカイン学会学術集会抄録集. 2022. 2022 (CD-ROM)
HIRANUMA Ryosuke, SATO Ryota, MIYAKE Kensuke. Molecular mechanisms by which mTORC1 drives granulomas. 日本免疫学会総会・学術集会記録(CD-ROM). 2022. 51
SAITOH Shin-Ichiroh, HARADA Kenichi, MORI-SAITOH Yoshiko, SUN-WADA Ge-Hong, DENDA Tamami, OTA Yasunori, SAGARA Hiroshi, WATANABE Yuji, WADA Yoh, MIYAKE Kensuke, et al. Endosomal abnormalities in dendritic cells cause autoimmune liver diseases. 日本免疫学会総会・学術集会記録(CD-ROM). 2022. 51

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