Rchr
J-GLOBAL ID：201701002711925515   Update date: Nov. 29, 2024

Sugisawa Ryoichi

スギサワ リョウイチ | Sugisawa Ryoichi
Affiliation and department：
Kindai University Faculty of Medicine Department of Medicine

About Kindai University Faculty of Medicine Department of Medicine


Job title： Assistant Professor
Research field  (4)： Pathobiochemistry ,  Immunology ,  Medical biochemistry ,  Veterinary medicine
Research keywords  (18)： Macrophage ,  Innate Immunity ,  Inflammation ,  Immunometabolism ,  TLR ,  Inflammasome ,  NADase ,  Auto immune disease ,  Fatty liver ,  Obesity ,  Kidney disease ,  Neuronal disorder ,  Axon degeneration ,  Transgenic mice models ,  Cat / Felis catus ,  AIM / CD5L ,  SARM1 ,  NAD
Research theme for competitive and other funds  (5)：
  • 2024 - 2028 Elucidating the role of SARM1 in senescence and aging related diseases
  • 2024 - 2025 2023 Kindai University Research Enchancement Grant
  • 2023 - 2025 Elucidating the role of SARM1 under inflammation
  • 2023 - 2024 Suzuken Memorial Foundation Research grant (2023)
  • 2017 - 2017 Analysis of the effect of inseparable association of AIM with IgM on obesity-related diseases
Papers (13)：
  • Masahiko Honda, Ryota Inoue, Kuniyuki Nishiyama, Takeshi Ueda, Akiyoshi Komuro, Hisayuki Amano, Ryoichi Sugisawa, Suman Dash, Jun Shirakawa, Hitoshi Okada. Vgll2 as an integrative regulator of mitochondrial function and contractility specific to skeletal muscle. Journal of Cellular Physiology. 2024
  • Ryoichi Sugisawa, Katharine A. Shanahan, Gavin Davis, Gavin Davey, Andrew G. Bowie. SARM1 regulates pro-inflammatory cytokine expression in human monocytes by NADase-dependent and -independent mechanisms. iScience. 2024. 109940-109940
  • Suman Dash, Takeshi Ueda, Akiyoshi Komuro, Masahiko Honda, Ryoichi Sugisawa, Hitoshi Okada. Deoxycytidine kinase inactivation enhances gemcitabine resistance and sensitizes mitochondrial metabolism interference in pancreatic cancer. Cell Death & Disease. 2024
  • Katharine A. Shanahan, Gavin M. Davis, Ciara G. Doran, Ryoichi Sugisawa, Gavin P. Davey, Andrew G. Bowie. SARM1 regulates NAD+-linked metabolism and select immune genes in macrophages. Journal of Biological Chemistry. 2024
  • Masaki Watanabe, Ryo Ando, Ryoichi Sugisawa, Nobuya Sasaki, Satomi Iwai. A novel in vivo model of ureteral fibrosis induced by calcium oxalate beads in C57BL/6J mice. Urolithiasis. 2023. 51. 1. 119
ｍore...
MISC (5)：
  • Ryoichi Sugisawa, Masahiko Honda, Suman Dash, Akiyoshi Komuro, Takeshi Ueda, Andrew Bowie, Hitoshi Okada. SARM1 regulates pro-IL-1β expression in monocytes by an NADase-dependent mechanism. European Journal of Immunology. 2024. 54. S1
  • Claudia Feriotti, Joana Sa-Pessoa, Ricardo Calderón-González, Lili Gu, Brenda Morris, Ryoichi Sugisawa, Jose L. Insua, Michael Carty, Amy Dumigan, Rebecca J. Ingram, et al. Klebsiella pneumoniae hijacks the Toll-IL-1R protein SARM1 in a type I IFN-dependent manner to antagonize host immunity. bioRxiv. 2021
  • Ciara G. Doran, Ryoichi Sugisawa, Michael Carty, Fiona Roche, Claire Fergus, Karsten Hokamp, Vincent P. Kelly, Andrew G Bowie. Next generation SARM1 knockout and epitope tagged CRISPR-Cas9-generated isogenic mice reveal that SARM1 does not participate in regulating nuclear transcription, despite confirmation of protein expression in macrophages. bioRxiv. 2021
  • Ryoichi Sugisawa, Ciara G Doran, Andrew G Bowie. Generation and initial characterization of a SARM epitope-tagged mouse. European Journal of Immunology. 2021. 51. (Suppl. 1). 207-207
  • 杉澤良一, 新井郷子, 北田研人, 森伸子, 岩井聡美, 岡田ゆう紀, 新井敏郎, 宮崎徹. ネコ急性腎障害モデルにおけるApoptosis inhibitor of macrophage(AIM)の役割. 日本腎臓学会誌. 2015. 57. 3. 497-497
Lectures and oral presentations  (24)：
  • The role of epigenetic regulator UTX in breast cancer invasion and lung metastasis
  • In vivo modeling of myeloid transformation induced by neddylation E2 enzyme deletion
    (2024)
  • Exploring how SARM1 regulates Innate immune responses by an NADase-dependent mechanism
    (The 97th Annuak Meeting of Japanese Biochemical Society 2024)
  • SARM1のNADase活性依存的な細胞内代謝と炎症性サイトカイン発現制御の検討
    (The 167th meeting of the Japanese Society of Veterinary Science 2024)
  • SARM1 regulates pro-IL-1β expression in monocytes by an NADase-dependent mechanism
    (7th European Congress of Immunology - ECI2024 2024)
ｍore...
Education (2)：
  • 2013 - 2017 The University of Tokyo Faculty of Medicine Laboratory of Molecular Biomedicine for Pathogenesis, Center for Disease Biology and Integrative Medicine
  • 2007 - 2013 Nippon Veterinary and Life science University Faculty of Veterinary Science School of Veterinary Medicine
Professional career (1)：
  • Ph.D. (The University of Tokyo)
Work history (3)：
  • 2023/04 - 現在 Kindai University, Faculty of Medicine Dept. of Biochemistry Assistant Professor
  • 2017/12 - 2023/03 Trinity College Dublin School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute Research Fellow
  • 2017/04 - 2017/11 The University of Tokyo, Faculty of Medicine Project Assistant Professor
Awards (4)：
  • 2021/09 - EFIS (European Federation of Immunological Societies) Waived Registration Grant (for Virtual 6th European Congress of Immunology - ECI 2021)
  • 2019/09 - The Japanese Society of Veterinary Science Veterinary Science Young Investigator Awards
  • 2018/11 - HOST-PATHOGEN COMMUNICATION TRAVEL AWARD
  • 2016/09 - The 159th meeting of the Japanese Society of Veterinary Science Young Investigator Award (Physiology and Biochemistry Subcommittee of The Japanese Society of Veterinary Science)
Association Membership(s) (5)：
The Japanese Biochemical Society ,  THE MOLECULAR BIOLOGY SOCIETY OF JAPAN ,  THE JAPANESE SOCIETY OF VETERINARY SCIENCE ,  Irish Society for Immunology ,  International Cytokine & Interferon Society
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