Okudaira Noriyuki

オクダイラノリユキ | Okudaira Noriyuki

Affiliation and department：
Job title：助教

Research field (3)： Cell biology , Medical biochemistry , Genomics

Research keywords (5)：老化 , ヘテロサイクリックアミン , 発がん機構 , LINE-1 , retroelement

Research theme for competitive and other funds (14)：

2023 - 2026 老化による副腎皮質組織のグルココルチコイド分泌撹乱とゲノム不安定性との連関性
2020 - 2023 Elucidation of selective cytotoxicity against malignant cells by chromone derivatives
2020 - 2023 Development of minimally invasive therapy for oral cancer by hyperthermia with tumor-specific targeting magnetic nanoparticles
2020 - 2023 加熱食品由来発癌物質のゲノム不安定性作用に対するレスベラトロールの遺伝子制御機構
2016 - 2019 Basic study of the possibility of newly synthesized 3-styrylchromone derivatives as therapeutic drugs for oral cancer

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Papers (39)：

Noriyuki Okudaira, Mi-Ho Akimoto, Takao Susa, Miho Akimoto, Harumi Hisaki, Masayoshi Iizuka, Hiroko Okinaga, Julio A Almunia, Noboru Ogiso, Tomoki Okazaki, et al. Accumulation of senescent cells in the adrenal gland induces hypersecretion of corticosterone via IL1β secretion. Aging cell. 2024. e14206
Miho Akimoto, Takao Susa, Noriyuki Okudaira, Nobuko Koshikawa, Harumi Hisaki, Masayoshi Iizuka, Hiroko Okinaga, Keizo Takenaga, Tomoki Okazaki, Mimi Tamamori-Adachi. Hypoxia induces downregulation of the tumor-suppressive sST2 in colorectal cancer cells via the HIF-nuclear IL-33-GATA3 pathway. Proceedings of the National Academy of Sciences of the United States of America. 2023. 120. 18. e2218033120
諏佐崇生, 坪井栄希, 秋元美穂, 奥平准之, 飯塚眞由, 岡崎具樹, 安達三美[玉盛]. アンドロゲン受容体およびスプライシングバリアントに対するHOXC9阻害作用の解析. 日本生化学会大会プログラム・講演要旨集. 2022. 95回. 1T11a-08
奥平准之, 秋元美穂, 諏佐崇生, 小原幸弘, 久樹晴美, 飯塚眞由, 岡崎具樹, 安達三美[玉盛]. 加齢に伴うマウスコルチコステロンの日内リズム破綻のメカニズムの解析. 日本生化学会大会プログラム・講演要旨集. 2022. 95回. 1T14a-04
Miho Akimoto, Takao Susa, Noriyuki Okudaira, Harumi Hisaki, Masayoshi Iizuka, Hiroko Okinaga, Tomoki Okazaki, Mimi Tamamori-Adachi. A Novel LncRNA PTH-AS Upregulates Interferon-Related DNA damage resistance Signature genes and Promotes Metastasis in Human Breast Cancer Xenografts. The Journal of biological chemistry. 2022. 298. 7. 102065-102065

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MISC (3)：

久樹晴美, 諏佐崇生, 奥平准之, 秋元美穂, 安達三美[玉盛], 内田俊也, 岡崎具樹. Saposin D欠損マウスの多飲症はプロサポシンの増加が原因か?. 日本生化学会大会プログラム・講演要旨集. 2022. 95回. 3P-369
奥平准之, 秋元美穂, 諏佐崇生, 秋元美穂, 小原幸弘, 久樹晴美, 飯塚眞由, 岡崎具樹, 安達(玉盛)三美. Mechanisms of adrenal aging and enhancement of the Glucocorticoid-system. 日本分子生物学会年会プログラム・要旨集(Web). 2022. 45th
Noriyuki Okudaira, Motohito Goto, Junko Tanuma, Kenta Iijima, Tadashi Okamura, Hiroyuki Gatanaga, Shinichi Oka, Yukihito Ishizaka. Vpr induces retrotransposition of long interspersed nucleotide element-1 in brain tissues: implication for HIV-1-induced dysfunction of CNS. EUROPEAN JOURNAL OF MEDICAL RESEARCH. 2010. 15. 8. 324-325

Professional career (1)：

博士(医学) (筑波大学)

Work history (4)：

2020/06 - 現在帝京大学医学部生化学講座助教
2015/09 - 2020/03 Meikai University School of Dentistry
2012/04 - 2015/03 Hyogo College of Medicine Faculty of Medicine
2007/05 - 2012/03 国立国際医療研究センター研究所難治性疾患研究部

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