Okanishi Hiroki

オカニシヒロキ | Okanishi Hiroki

Affiliation and department：

Research field (1)： Molecular biology

Research theme for competitive and other funds (9)：

2022 - 2025 アミノ酸輸送体LAT1依存的リン酸化シグナルにおけるチロシンリン酸化制御機構解明
2022 - 2025 がん細胞アミノ酸輸送体阻害薬の強力な細胞周期制御の機序と細胞休眠化機構の解明
2020 - 2023 新規細胞内アミノ酸センサーの同定と分子機構解明および創薬標的としての可能性の探索
2019 - 2022 Study on the amino acid signaling via transporters and receptors for the pharmacologic control of cellular metabolism
2019 - 2022 Revealing of phosphorylation signaling in the downstream of LAT1 in cancer cells

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Papers (24)：

Yu Ma, Suguru Okuda, Hiroki Okanishi, Minhui Xu, Chunhuan Jin, Hitoshi Endou, Ryuichi Ohgaki, Yoshikatsu Kanai. Upregulation of ATF4 mediates the cellular adaptation to pharmacologic inhibition of amino acid transporter LAT1 in pancreatic ductal adenocarcinoma cells. Journal of Pharmacological Sciences. 2024. 155. 1. 14-20
Xinyu Zhou, Ryuichi Ohgaki, Chunhuan Jin, Minhui Xu, Hiroki Okanishi, Hitoshi Endou, Yoshikatsu Kanai. Inhibition of amino acid transporter LAT1 in cancer cells suppresses G0/G1-S transition by downregulating cyclin D1 via p38 MAPK activation. Journal of Pharmacological Sciences. 2024. 154. 3. 182-191
Sihui Chen, Chunhuan Jin, Ryuichi Ohgaki, Minhui Xu, Hiroki Okanishi, Yoshikatsu Kanai. Structure-activity characteristics of phenylalanine analogs selectively transported by L-type amino acid transporter 1 (LAT1). Scientific Reports. 2024. 14. 1
Xingming Liu, Kou Nishikubo, Ryuichi Ohgaki, Hiroki Okanishi, Suguru Okuda, Minhui Xu, Yoshikatsu Kanai. Identification of tumor-suppressive miRNAs that target amino acid transporter LAT1 and exhibit anti-proliferative effects on cholangiocarcinoma cells. Journal of Pharmacological Sciences. 2024
Zitong Shi, Kazuko Kaneda-Nakashima, Ryuichi Ohgaki, Minhui Xu, Hiroki Okanishi, Hitoshi Endou, Shushi Nagamori, Yoshikatsu Kanai. Inhibition of Cancer-type Amino Acid Transporter LAT1 Suppresses B16-f10 Melanoma Metastasis in Mouse Models. Scientific Reports. 2023. 13. 1. 13943-13943

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MISC (9)：

Acyl-Proteome with Protein Tertiary Structure Information Reveals the Significance of Lysine Acylations. Proteome Letters. 2018. 3. 1. 15-22
Norie Araki, Akiko N. Nambu, Atit Silsirivanit, Hiroki Okanishi, Daiki Kobayashi, Takuichiro Hide, Hideo Nakamura. Studies of key signals related to the maintenance and differentiation of glioma initiating cells by integrated-omics. CANCER SCIENCE. 2018. 109. 630-630
小林大樹, 徳田高穂, 岡西広樹, 大槻純男, 荒木令江. TCTP-EF1A2-翻訳伸長因子複合体を介した神経線維腫症1型腫瘍特異的な翻訳機構の解析. 生命科学系学会合同年次大会. 2017. 2017年度. [3LBA-029]
荒木令江, 南部晶子, 堀, シルシリバニット・アチト, 岡西広樹, 小林大樹, 秀拓一郎, 中村英夫. 融合オミクスによるグリオーマ幹細胞の分化と維持に関わる鍵分子群の同定と機能制御の解析. 日本癌学会総会記事. 2017. 76回. P-2117
岡西広樹, 鷲頭朋之, 南部晶子, 小林大樹, 荒木令江. グリオーマ幹細胞における翻訳後修飾アセチル化の分化変動プロテオミクス. 日本プロテオーム学会大会プログラム・抄録集. 2017. 2017. 194

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Lectures and oral presentations (7)：

がん特異的アミノ酸トランスポーターLAT1阻害薬JPH203による胆道がん細胞内アミノ酸プールの破綻に伴うリン酸化プロテオーム解析
(第142回日本薬理学会近畿部会 2022)
胆道がん細胞株におけるアミノ酸トランスポーターLAT1阻害薬が示す増殖抑制作用のタンパク質発現・リン酸化変動の網羅的解析による検討
(第140回日本薬理学会近畿部会 2021)
Proteomics and phosphoproteomics on biliary tract cancer cells treated with a selective LAT1 inhibitor, JPH203
(The 94th Annual Meeting of the Japanese Biochemical Society 2021)
Proteomics of post-translational lysine acetylation in glioma-derived stem cells
(16th Human Proteome Organization World Congress 2017 2017)
Lysine propionylation is a novel post-translational modification occurring on many bacterial proteins
(8th Asia Oceania Human Proteome Organization 2016)

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Education (3)：

2013 - 2016 Osaka University Graduate School of Science Department of Biological Sciences, PhD course
2011 - 2013 Osaka University Graduate School of Science Department of Biological Sciences, MS course
2007 - 2011 Osaka University Faculty of Science Department of Biological Sciences

Professional career (1)：

Work history (4)：

Awards (3)：

2016/12 - 日本分子生物学会第39回日本分子生物学会年会優秀ポスター賞バクテリアにおける翻訳後修飾アシル化プロテオミクス
2015/12 - モデル生物丸ごと一匹学会第5回モデル生物学会優秀発表賞 Proteome-wide analysis showed the abundance of lysine propionylation and its physiological significance
2014/06 - 日本蛋白質科学会第14回日本蛋白質科学会年会ポスター賞高度好熱菌Thermus thermophilus HB8におけるオミクス的解析: アセチル化プロテオーム解析

Association Membership(s) (4)：

日本分子生物学会 , 日本生化学会 , 日本プロテオーム学会 , 日本薬理学会

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