Yamada Tsuyoshi

Research field (3)： Genetics , Molecular biology , Dermatology

Research keywords (7)： infectious diseases , 真菌 , drug resistance , 遺伝学・遺伝子工学 , Ringworm , Dermatophytes , Virulence

Research theme for competitive and other funds (14)：

2024 - 2027 Elucidation of fermented natto-based foods in the Jomon period
2023 - 2026 Establishment of therapeutic strategy for antifungal drug-resistant dermatophytosis based on control of drug efflux pumps
2023 - 2024 白癬菌に拡がるアゾール系抗真菌薬耐性化の分子メカニズムの解析
2020 - 2024 Functions and roles of proteases in dermatophyte infection mechanism
2022 - 2023 白癬菌に拡がるアゾール系抗真菌薬耐性化の分子メカニズムの解析

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Papers (40)：

Masaki Ishii, Yasuhiko Matsumoto, Tsuyoshi Yamada, Hideko Uga, Toshiaki Katada, Shinya Ohata. Targeting dermatophyte Cdc42 and Rac GTPase signaling to hinder hyphal elongation and virulence. iScience. 2024. 27. 6. 110139-110139
Masaki Ishii, Tsuyoshi Yamada, Kazuki Ishikawa, Koji Ichinose, Michel Monod, Shinya Ohata. The Ptk2-Pma1 pathway enhances tolerance to terbinafine in Trichophyton rubrum. Antimicrobial Agents and Chemotherapy. 2024. 68. 5. e0160923
Masaki Ishii, Tsuyoshi Yamada, Shinya Ohata. An efficient gene targeting system using Δku80 and functional analysis of Cyp51A in Trichophyton rubrum. bioRxiv. 2024
Rui Kano, Tsuyoshi Yamada, Takashi Tamura, Koichi Makimura. Is milbemycin a game changer against antifungal drug-resistant mycoses?. Medical mycology. 2024. 62. 2. myae003.
Tsuyoshi Yamada, Honoka Nojo, Rui Kano. Long amplification PCR (LA-PCR) detection of azole resistant Trichophyton indotineae. Mycopathologia. 2023. 188. 6. 1085-1088

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MISC (7)：

Dermatophyte resistance to antifungal drugs: current situation and mechanisms. Medical Mycology Journal. 2022. 63. 4. 89-92
毛髪穿孔試験. Medical Mycology Journal. 2022. 63. 3. 75-75
Urease test. Medical Mycology Journal. 2021. 62. 3. 37-37
Mohamed Mahdi Alshahni, Tsuyoshi Yamada. Genetic Manipulations in Dermatophytes. Mycopathologia. 2017. 182. 1-2. 33-43
Tsuyoshi Yamadai, Koichi Makimura. The Current Status of Tinea (Ringworm) and the Progress of Research on Pathogenesis of Dermatophytes. The Journal of the Japanese Society for Clinical Microbiology. 2011. 21. 1. 1-10

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Patents (4)：

Books (4)：

Lectures and oral presentations (58)：

病原真菌Trichosporon asahiiの病原性関連因子の評価におけるカイコ感染モデルの利用
(第67回日本医真菌学会学術集会 2023)
カイコ感染モデルを用いた深在性真菌症を引き起こす真菌の病原性関連因子の評価
(第42回関東医真菌懇話会 2023)
白癬菌Trichophyton indotineaeで見つかったアゾール系抗真菌薬に対する新たな低感受性化のメカニズム
(第96回日本細菌学会総会 2023)
病原真菌Trichosporon asahiiの病原性におけるカルシニューリン経路の役割
(第96回日本細菌学会総会 2023)
病原真菌Trichosporon asahiiの感染機構の解明に向けた遺伝学的基盤技術の構築
(第143回日本薬学会第143年会 2023)

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Education (1)：

Professional career (1)：

Work history (2)：

2018/08 - 現在 Asia International Institute of Infectious Disease Control, Teikyo University
2012/04 - 現在 Teikyo University Institute of Medical Mycology Associate Professor

Awards (2)：

2019/06 - 第40回関東医真菌懇話会優秀演題賞白癬菌Trichophyton benhamiaeにおけるFLP site-specific recombinaseを用いた薬剤耐性マーカーリサイクルシステムの構築と遺伝子破壊株の作出
2009/06 - 第53回日本医真菌学会総会・学術集会日本医真菌学会奨励賞白癬菌の感染メカニズムの解析に役立つ効率的遺伝子操作技術の構築

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