Rchr
J-GLOBAL ID：201701005552651149   Update date: Feb. 29, 2024

Oisaki Kounosuke

オイサキ コウノスケ | Oisaki Kounosuke
Affiliation and department：
National Institute of Advanced Industrial Science and Technology (AIST) Interdisciplinary Research Center for Catalytic Chemistry (IRC3), Functional Group Transformation Team

About National Institute of Advanced Industrial Science and Technology (AIST) Interdisciplinary Research Center for Catalytic Chemistry (IRC3), Functional Group Transformation Team


Job title： Team Leader
Other affiliations (2)：
  • Chem-Station  Deputy Director
  • University of Tsukuba  School of Integrative and Global Major   Associate Professor
Homepage URL  (1)： https://k-oisaki.raindrop.jp/
Research field  (5)： Biochemistry ,  Bioorganic chemistry ,  Structural/physical organic chemistry ,  Pharmaceuticals - chemistry and drug development ,  Synthetic organic chemistry
Research keywords  (6)： Peptide Chemistry ,  Protein Chemistry ,  Homogeneous Catalysis ,  Synthetic Chemistry ,  Medicinal Chemistry ,  Organic Chemistry
Research theme for competitive and other funds  (25)：
  • 2022 - 2027 生体適合エネルギーが駆動するタンパク質化学修飾法
  • 2023 - 2025 Catalytic strategies for biomolecule functionalization and generation of pseudo natural products
  • 2023 - 2025 Innovative peptide synthesis minimizing waste
  • 2021 - 2024 Regulation of membrane dynamics by glycan chemical knock-in
  • 2022 - 2024 新規環状アミノ酸のLate-Stage構築法の開発とペプチド配座への影響
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Papers (49)：
  • Toshifumi Tatsumi, Koki Sasamoto, Takuya Matsumoto, Ryo Hirano, Kazuki Oikawa, Masato Nakano, Masaru Yoshida, Kounosuke Oisaki, Motomu Kanai. Practical N-to-C peptide synthesis with minimal protecting groups. Communications Chemistry. 2023. 6. 1. 231
  • Katarzyna Joanna Malawska, Shinjiro Takano, Kounosuke Oisaki, Haruaki Yanagisawa, Masahide Kikkawa, Tatsuya Tsukuda, Motomu Kanai. Bioconjugation of Au25 Nanocluster to Monoclonal Antibody at Tryptophan. Bioconjugate Chemistry. 2023. 34. 4. 781-788
  • Takaaki Tatsuguchi, Takehito Uruno, Yuki Sugiura, Kounosuke Oisaki, Daisuke Takaya, Daiji Sakata, Yoshihiro Izumi, Takaya Togo, Yuko Hattori, Kazufumi Kunimura, et al. Pharmacological intervention of cholesterol sulfate-mediated T cell exclusion promotes antitumor immunity. Biochemical and biophysical research communications. 2022. 609. 183-188
  • Kentaro Sakai, Kounosuke Oisaki, Motomu Kanai. A Germanium Catalyst Accelerates the Photoredox α-C(sp3)-H Alkylation of Primary Amines. Organic Letters. 2022. 24. 18. 3325-3330
  • Katsuya Maruyama, Takashi Ishiyama, Yohei Seki, Kentaro Sakai, Takaya Togo, Kounosuke Oisaki, Motomu Kanai. Protein Modification at Tyrosine with Iminoxyl Radicals. Journal of the American Chemical Society. 2021. 143. 47. 19844-19855
ｍore...
MISC (30)：
  • Kounosuke Oisaki. Research and Carreer Guided by Planned Happenstance Mindset. Journal of Synthetic Organic Chemistry, Japan. 2023. 81. 4. 366-380
  • 金井求, 生長幸之助, 豊邉萌. レドックス活性を利用した抗体修飾と応用. MEDCHEM NEWS. 2023. 33. 1. 33-37
  • 清川慎介, 安田大輔, 生長幸之助. 新たな機能性分子を合成する手法“クリックケミストリー”-2022年ノーベル化学賞によせて. 医学の歩み. 2022. 283. 13. 1173-1175
  • Kounosuke Oisaki, Keisuke Asano, Yoshihiro Ueda. Planned serendipity from organocatalyst discovery. Igaku no Ayumi. 2022. 282. 9. 23261-23263
  • 星本陽一, 生長 幸之助. 化学系プレプリントサーバー ChemRxivが呼んでいる!. 現代化学. 2022. 8. 55-57
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Patents (9)：
  • SULT2B1b阻害剤、 CS生成阻害剤、及び抗がん免疫増強作用を有する医薬組成物
  • ペプチド合成法
  • IL-31産生抑制剤
  • DOCK1 inhibitory compounds and their uses
  • アミノ酸残基選択的な不可逆/可逆生体分子修飾法
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Books (1)：
  • 「ペプチド創薬の最前線」
    シーエムシー出版 2019 ISBN:9784781314174
Lectures and oral presentations  (268)：
  • タンパク質の化学アップグレード法
    (第46回日本分子生物学会年会 2023)
  • Bioconjugation of Au25 Nanocluster to Monoclonal Antibody at Tryptophan
    (2023)
  • ペプチドチオ酸カップリング伸長反応
    (第49回反応と合成の進歩シンポジウム 2023)
  • Chemical Upgrading of Peptides and Proteins
    (Open T-LSI Seminar 2023)
  • 「タンパク質の化学アップグレード法」に至るまでの合成化学者奮闘記
    (東京農工大学 2023)
ｍore...
Works (1)：
  • カプセルトイ『分子博物館』
    古川俊輔, 生長 幸之助, 佐藤健太郎, 小林沙羅, 鈴木寛人 2021 - 現在
Education (4)：
  • 2005 - 2008 The University of Tokyo Graduate School of Pharmaceutical Sciences Ph.D. Course
  • 2003 - 2005 The University of Tokyo Graduate School of Pharmaceutical Sciences M.Sc. Course
  • 2001 - 2003 The University of Tokyo Department of Pharmaceutical Sciences
  • 1999 - 2001 The University of Tokyo Department of Arts and Sciences Natural Sciences I
Professional career (3)：
  • PhD (Pharmaceutical Sciences) (The University of Tokyo)
  • MSc (Pharmaceutical Sciences) (The University of Tokyo)
  • BSc (Pharmaceutical Sciences) (The University of Tokyo)
Work history (10)：
  • 2023/04 - 現在 National Institute of Advanced Industrial Science and Technology Interdisciplinary Research Center for Catalytic Chemistry (IRC3), Functional Group Transformation Team Team Leader
  • 2022/12 - 現在 University of Tsukuba School of Integrative and Global Major (SIGMA) Associate Professor
  • 2022/04 - 現在 Open Innovation Laboratory for Food and Medicinal Resource Engineering (FoodMedOIL) Project Researcher
  • 2002 - 現在 Chem-Station Deputy Director
  • 2022/04 - 2023/03 National Institute of Advanced Industrial Science and Technology Interdisciplinary Research Center for Catalytic Chemistry (IRC3), Functional Group Transformation Team Senior Researcher
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Committee career (4)：
  • 2020/01 - 現在 International Union of Pure and Applied Chemistry (IUPAC) Committee on Publications and Cheminformatics Data Standards (CPCDS)
  • 2019/01 - 現在 ChemRxiv Scientific Advisory Board
  • 2018/04 - 2019/03 科学技術・学術政策研究所 (NISTEP) 専門調査員
  • 2017/06 - 2018/03 有機合成化学協会 第二分科会委員
Awards (15)：
  • 2024/02 - 日本化学連合 化学コミュニケーション賞2023 化学系バーチャルシンポジウムの開拓と実践
  • 2021/01 - Thieme Chemistry Synthesis Best Paper Award 2020 A Bond-Weakening Borinate Catalyst that Improves the Scope of the Photoredox α-C-H Alkylation of Alcohols
  • 2020/12 - The Cambridge Crystallographic Data Centre CCDC Annual 3D Print Contest, Winnter
  • 2019/05 - Ministry of Education, Culture, Sports, Science and Technology (MEXT) The Commendation for Science and Technology by the Minister of Education, Culture, Sports, Science and Technology, Prizes for Science and Technology [Public Understanding Promotion Category]
  • 2019/05 - Lectureship Award
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Association Membership(s) (14)：
The Japanese Society of Carbohydrate Research ,  有機電子移動化学研究会 ,  JAPANESE SOCIETY FOR CHEMICAL BIOLOGY ,  Japan Society for Science Visualization ,  American MENSA ,  American Chemical Society ,  THE SOCIETY OF SYNTHETIC ORGANIC CHEMISTRY, JAPAN ,  THE CHEMICAL SOCIETY OF JAPAN ,  THE PHARMACEUTICAL SOCIETY OF JAPAN ,  ARchemisT ,  Protein Science Society of Japan ,  The Japanese Peptide Society ,  ISI-Society ,  HELLIQ Society
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